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035 a| (Sirsi) o57226061;

035 a| (OCoLC)57226061;

049 a| EREE;

050 4 a| QP552.P4b| W48 2003;

100 1 a| Westerkamp, Christopher M.,e| author.?| UNAUTHORIZED;

245 14 a| The effects of angiotensin converting enzyme (ACE) inhibition on nuclear proliferation and hypertrophy in overloaded skeletal muscle /c| by Christopher M. Westerkamp.;

264 0 c| 2003.;

300 a| vi, 88 leaves :b| illustrations ;c| 28 cm;

336 a| textb| txt2| rdacontent;

337 a| unmediatedb| n2| rdamedia;

338 a| volumeb| nc2| rdacarrier;

502 b| M.A.c| East Carolina Universityd| 2003;

500 a| Presented to the faculty of the Department of Exercise and Sports Science.;

500 a| Advisor: Scott E. Gordon;

520 3 a| The purpose of this study was to determine the effects of ACE inhibition on nuclear proliferation and hypertrophy in overloaded skeletal muscle. In a 2 x 2 design, adult female Sprague Dawley rats were placed into one of four groups (n = 8/group): 7- day skeletal muscle overload (O), sham-operation (S), 7-day skeletal muscle overload with ACE inhibition (OA), or sham operation with ACE inhibition (SA). Functional overload of the plantaris and soleus muscles was produced by bilateral surgical ablation of the synergistic gastrocnemius muscles, while ACE inhibition was accomplished via the addition of the ACE inhibitor enalapril maleate (0.3 mg/ml) to the animals' daily drinking water 2 days prior and 7 days post-surgery. Cross-sections of plantaris and soleus muscles from all groups were immunohistochemically stained for dystrophin and bromodeoxyuridine (BrdU). As expected, satellite cell proliferation was significantly higher (p < 0.05) in O compared to S in both the soleus and plantaris muscles. ACE inhibition attenuated this increase in OA soleus but not OA plantaris muscles. Extra-sarcolemmal nuclear proliferation was significantly higher in O compared to S in both the soleus and plantaris muscles, but again only attenuated with ACE inhibition in the OA soleus and not the OA plantaris muscle. Plantaris muscle protein content, wet weight, and fiber cross-sectional area were all increased in O compared to S, and attenuated in OA 7 days post-surgery. There were no differences in soleus muscle total protein content or fiber cross-sectional area after 7 days between any of the groups, but there was an increase in soleus muscle wet weight in the O compared to the S that was attenuated in OA. Collectively, these data indicate that ACE inhibition may attenuate proliferation of satellite cells and other nuclei in overloaded skeletal muscle, but that this effect may depend upon the muscle and/or predominant fiber type being studied.;

504 a| Includes bibliographical references (leaves 74-87).;

650 0 a| Peptides.=| ^A3253;

650 0 a| Angiotensin converting enzymex| Inhibitors.=| ^A588276;

650 0 a| Musculoskeletal systemx| Hypertophy.=| ^A4330;

650 0 a| Cell nuclei.=| ^A54287;

650 7 a| Angiotensin converting enzymex| Inhibitors.2| fast0| (OCoLC)fst00808853;

650 7 a| Cell nuclei.2| fast0| (OCoLC)fst00850208;

650 7 a| Peptides.2| fast0| (OCoLC)fst01057564;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

700 1 a| Gordon, Scott Edward,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina College.b| Department of Exercise and Sport Science.?| UNAUTHORIZED;

856 41 z| Access via ScholarShipu| http://hdl.handle.net/10342/10297;

949 a| Click on web addressw| asish| joyner101;

949 a| Click on web addressw| asish| hsl111;

994 a| C0b| ERE;

596 a| 1 4;

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999 a| ASK AT SPECIAL COLLECTIONS DESKw| ASISc| 1i| MQ1735929l| JSCJTHDm| JOYNERr| Ys| Yt| JSCJTHDu| 12/14/2004x| ETDz| JSPECCOLLo| .STAFF. 0;

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The effects of angiotensin converting enzyme (ACE) inhibition on nuclear proliferation and hypertrophy in overloaded skeletal muscle / by Christopher M. Westerkamp.

Author/creator	Westerkamp, Christopher M. author.
Other author	Gordon, Scott Edward, degree supervisor.
Other author	East Carolina College. Department of Exercise and Sport Science.
Format	Theses and dissertations
Production	2003.
Description	vi, 88 leaves : illustrations ; 28 cm
Supplemental Content	Access via ScholarShip
Subjects	Peptides. Angiotensin converting enzyme--Inhibitors. Musculoskeletal system--Hypertophy. Cell nuclei.

Summary	The purpose of this study was to determine the effects of ACE inhibition on nuclear proliferation and hypertrophy in overloaded skeletal muscle. In a 2 x 2 design, adult female Sprague Dawley rats were placed into one of four groups (n = 8/group): 7- day skeletal muscle overload (O), sham-operation (S), 7-day skeletal muscle overload with ACE inhibition (OA), or sham operation with ACE inhibition (SA). Functional overload of the plantaris and soleus muscles was produced by bilateral surgical ablation of the synergistic gastrocnemius muscles, while ACE inhibition was accomplished via the addition of the ACE inhibitor enalapril maleate (0.3 mg/ml) to the animals' daily drinking water 2 days prior and 7 days post-surgery. Cross-sections of plantaris and soleus muscles from all groups were immunohistochemically stained for dystrophin and bromodeoxyuridine (BrdU). As expected, satellite cell proliferation was significantly higher (p < 0.05) in O compared to S in both the soleus and plantaris muscles. ACE inhibition attenuated this increase in OA soleus but not OA plantaris muscles. Extra-sarcolemmal nuclear proliferation was significantly higher in O compared to S in both the soleus and plantaris muscles, but again only attenuated with ACE inhibition in the OA soleus and not the OA plantaris muscle. Plantaris muscle protein content, wet weight, and fiber cross-sectional area were all increased in O compared to S, and attenuated in OA 7 days post-surgery. There were no differences in soleus muscle total protein content or fiber cross-sectional area after 7 days between any of the groups, but there was an increase in soleus muscle wet weight in the O compared to the S that was attenuated in OA. Collectively, these data indicate that ACE inhibition may attenuate proliferation of satellite cells and other nuclei in overloaded skeletal muscle, but that this effect may depend upon the muscle and/or predominant fiber type being studied.
General note	Presented to the faculty of the Department of Exercise and Sports Science.
General note	Advisor: Scott E. Gordon
Dissertation note	M.A. East Carolina University 2003
Bibliography note	Includes bibliographical references (leaves 74-87).
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

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