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035 a| (Sirsi) o56722044;

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049 a| EREE;

050 4 a| QR184.315b| .R66 2003;

100 1 a| Roney, Kelly Jones,e| author.?| UNAUTHORIZED;

245 10 a| Major histocompatibility complex class II DAB and DXB polymorphism in Xiphophorus fishes /c| by Kelly Jones Roney.;

264 0 c| 2003.;

300 a| 82 leaves :b| illustrations ;c| 28 cm;

336 a| textb| txt2| rdacontent;

337 a| unmediatedb| n2| rdamedia;

338 a| volumeb| nc2| rdacarrier;

502 b| M.S.c| East Carolina Universityd| 2003;

500 a| Presented to the faculty of the Department of Biology.;

500 a| Advisor: Thomas J. McConnell;

520 3 a| Classical MHC class II glycoproteins present peptides to T cells. Nonclassical class II glycoproteins mediate the unloading and loading of peptide from classical MHC class II. Classical MHC genes are usually highly polymorphic. Nonclassical class II genes have little or no variability. In fish, a classical MHC class II Zi-like transcript has been identified, DAB, as well as a divergent MHC class II 5-like transcript, DXB. In the two species of Xiphophorus fishes studied here, X. multilineatus and X. pygmaeus, DAB and DXB were isolated. DAB was highly polymorphic, and the 51 region of DAB, nonsynonymous and synonymous substitutions were found to have around a ten-fold increase versus the remainder of the transcript. DXB had very little variability. Alternative splicing of the DXB transcript was observed, but not of DAB. Two alternative splice patterns were found; a 16 codon deletion and a 5 nucleotide deletion that leads to an extension of the transcript. The alternative splice pattern, lack of polymorphsim, and divergence of DXB from DAB suggest that in fish, DXB may serve in a nonclassical MHC class II role and DAB in a classical roles.;

504 a| Includes bibliographical references (leaves 63-75).;

650 0 a| Major histocompatibility complexx| Genetic aspects.=| ^A476364;

650 0 a| Genetic polymorphisms.=| ^A141649;

650 0 a| Swordtails (Fish)=| ^A584583;

650 7 a| Genetic polymorphisms.2| fast0| (OCoLC)fst00940074;

650 7 a| Major histocompatibility complexx| Genetic aspects.2| fast0| (OCoLC)fst01006238;

650 7 a| Swordtails (Fish)2| fast0| (OCoLC)fst01140694;

655 7 a| dissertations.2| aat0| (CStmoGRI)aatgf300028029;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

700 1 a| McConnell, Thomas J.,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 41 z| Access via ScholarShipu| http://hdl.handle.net/10342/12736;

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Major histocompatibility complex class II DAB and DXB polymorphism in Xiphophorus fishes / by Kelly Jones Roney.

Author/creator	Roney, Kelly Jones author.
Other author	McConnell, Thomas J., degree supervisor.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Production	2003.
Description	82 leaves : illustrations ; 28 cm
Supplemental Content	Access via ScholarShip
Subjects	Major histocompatibility complex--Genetic aspects. Genetic polymorphisms. Swordtails (Fish)

Summary	Classical MHC class II glycoproteins present peptides to T cells. Nonclassical class II glycoproteins mediate the unloading and loading of peptide from classical MHC class II. Classical MHC genes are usually highly polymorphic. Nonclassical class II genes have little or no variability. In fish, a classical MHC class II Zi-like transcript has been identified, DAB, as well as a divergent MHC class II 5-like transcript, DXB. In the two species of Xiphophorus fishes studied here, X. multilineatus and X. pygmaeus, DAB and DXB were isolated. DAB was highly polymorphic, and the 51 region of DAB, nonsynonymous and synonymous substitutions were found to have around a ten-fold increase versus the remainder of the transcript. DXB had very little variability. Alternative splicing of the DXB transcript was observed, but not of DAB. Two alternative splice patterns were found; a 16 codon deletion and a 5 nucleotide deletion that leads to an extension of the transcript. The alternative splice pattern, lack of polymorphsim, and divergence of DXB from DAB suggest that in fish, DXB may serve in a nonclassical MHC class II role and DAB in a classical roles.
General note	Presented to the faculty of the Department of Biology.
General note	Advisor: Thomas J. McConnell
Dissertation note	M.S. East Carolina University 2003
Bibliography note	Includes bibliographical references (leaves 63-75).
Genre/form	dissertations.
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

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Major histocompatibility complex class II DAB and DXB polymorphism in Xiphophorus fishes / by Kelly Jones Roney.

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