Congenital heart diseases : the broken heart : clinical features, human genetics and molecular pathways / Silke Rickert-Sperling, Robert G. Kelly, Nikolaus Haas, editors.
| Other author | Rickert-Sperling, Silke, editor. |
| Other author | Kelly, Robert G. (Biologist), editor. |
| Other author | Haas, Nikolaus A., editor. |
| Format | Electronic |
| Edition | Second edition. |
| Publication | Cham : Springer, [2024] |
| Copyright Date | ©2024 |
| Description | 1 online resource (xxxiv, 1112 pages). |
| Supplemental Content | Direct link to eBook |
| Subjects |
| Series | Advances in experimental medicine and biology ; volume 1441 Advances in experimental medicine and biology ; v. 1441. |
| Contents | Intro -- Foreword of the 1st Edition -- Foreword of the 2nd Edition -- Preface -- Contents -- Contributors -- List of Abbreviations -- Part I: Introduction -- 1: Human Cardiac Development -- 1.1 Introduction -- 1.1.1 Sharing of Digitized Collections Allows for Higher-Quality Data -- 1.1.2 Sources of Additional Information -- 1.1.3 A Combination of Text and Three-Dimensional (3D) Images Is Necessary for Effective Communication -- 1.1.4 This Study -- 1.2 Formation of the Single Heart Tube (CS9-CS10) -- 1.2.1 Formation of Bilateral Heart Anlagen |
| Contents | 1.2.2 Appearance of the Vascular Network and Myocyte Contractility -- 1.2.3 The Single Cardiac Tube -- 1.2.4 The Pericardial Cavity and the Transverse Septum -- 1.3 Looping of the Heart (CS10-CS12) -- 1.3.1 Asymmetry of the Loop -- 1.3.2 Elongation of the Loop -- 1.3.3 Chirality of the Heart Loop -- 1.4 Formation of the Cardiac Compartments (CS11-CS14) -- 1.4.1 Cardiac Compartments Originate by ``Ballooning ́́of the Heart Tube -- 1.4.2 Formation of Ventricular Trabeculations -- 1.4.3 Development of the Pectinate Muscles of the Atriums -- 1.4.4 Formation of the Muscular Ventricular Septum |
| Contents | 1.4.5 Formation of the Definitive Left and Right Ventricles -- 1.4.6 The Conduction System -- 1.4.6.1 The Sinus Node -- 1.4.6.2 The Atrioventricular Node -- 1.4.6.3 The Ventricular Conduction System -- 1.4.7 Appearance of the Coronary Vessels -- 1.4.7.1 The Proepicardial Organ -- 1.4.7.2 Formation of the Coronary Arteries -- 1.4.7.3 Development of the Coronary Arterial Walls -- 1.4.7.4 Formation of the Cardiac Veins -- 1.5 Septation of the Heart (CS14-CS20) -- 1.5.1 The Phylotypic Stage and the Onset of Septation -- 1.5.2 Structural Changes in the Preseptational Heart |
| Contents | 1.5.3 Septation of the Venous Pole -- 1.5.3.1 Septation of the Veins -- The Fate of the Left Cranial Cardinal Vein -- 1.5.3.2 The Atrial Septum -- 1.5.3.3 Atrioventricular Septation -- 1.5.3.4 Growth of the Ventricles and Formation of the Muscular Ventricular Septum -- 1.5.4 Septation of the Arterial Pole -- 1.5.4.1 Development of the Temporary Arteries of the Cranial Pharyngeal Arches -- 1.5.4.2 Development of the Permanent Caudal Arch Arteries -- 1.5.4.3 The Fate of the Dorsal Aortas -- 1.5.4.4 The Growth Pattern of the Early Outflow Tract |
| Contents | 1.5.4.5 The Remarkable Subsequent Change in the Shape of the Late Outflow Tract -- 1.5.4.6 Invasion of Neural Crest Cells and Establishment of Spiraling Ridges -- 1.5.4.7 Formation of the Aortopulmonary Septum in the Distal Outflow Tract -- 1.5.4.8 Septation of the Middle Outflow Tract -- 1.5.4.9 Formation of the Non-Myocardial Intercalated Ridges (or Tongues) and Swellings -- 1.5.4.10 Appearance of the Arterial Trunks -- 1.5.4.11 The ``Arterial ́́Epicardium -- 1.5.4.12 The Arterial Valves -- 1.5.4.13 Septation of the Proximal Outflow Tract |
| Abstract | This 2nd edition has been extensively updated and provides comprehensive and current insight into congenital heart diseases, from embryonic development through to clinical features, including human genetics and our current knowledge of the underlying molecular pathways. The book is divided into three parts: an introduction to the development of the heart and its vessels, an overview of the molecular pathways affecting the development of various cardiovascular structures, and a main section focusing on the different types of structural and nonstructural congenital heart diseases, including their clinical features, underlying genetic alterations and insights from animal models and pathways. All chapters have been updated and new chapters added on state-of-the-art approaches including stem cells and organoids, cardiac metabolism, single cell transcriptomics and 3D reconstruction of human heart development. The clinical chapters have been extended and include new sections on diagnostic imaging techniques. Taken together, the book, written by and for clinicians and researchers, provides an integrated and up-to-date resource for all those who want to learn more about both the clinical aspects and the genetic and molecular basis of congenital heart disease. |
| General note | Includes index. |
| Source of description | Online resource; title from PDF title page (SpringerLink, viewed June 26, 2024). |
| Issued in other form | Original 3031440862 9783031440861 |
| ISBN | 9783031440878 (electronic bk.) |
| ISBN | 3031440870 (electronic bk.) |
| Standard identifier# | 10.1007/978-3-031-44087-8 |
Availability
| Library | Location | Call Number | Status | Item Actions |
|---|---|---|---|---|
| Electronic Resources | Access Content Online | ✔ Available |