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003 OCoLC;

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006 m o d ;

007 cr unu||||||||;

008 260729s2026 ncu obm 000 0 eng d;

040 a| EREb| enge| rdac| ERE;

035 a| (OCoLC)1609158794;

049 a| EREE;

100 1 a| Gilbert, Emma Adelinee| author;

245 10 a| INVESTIGATING POST-TRANSCRIPTIONAL REGULATION OVER MRNA FATE ACROSS THE MITOTIC-TO-MEIOTIC TRANSITION IN MALE GERM CELLS;

264 1 a| [Greenville, N.C.] :b| [East Carolina Universityc| 2026.];

300 a| 250 pages;

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text fileb| application/pdfc| 4.69 MB2| rda;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| Dr.Phil.c| East Carolina Universityd| 2026.;

504 a| Includes bibliographical references.;

520 3 a| Spermatogenesis requires carefully coordinated mRNA utilization throughout male germ cell development. Although it is recognized that post-transcriptional control of mRNAs is essential for spermatogenesis, little is known regarding how differential utilization of mRNAs results in successful entry of male germ cells into meiosis. The review (Chapter II) and studies (Chapters III-IV) included in the following dissertation seek to better understand the mechanisms that govern meiotic initiation. First, the current dogma surrounding the "meiosis-inducing substance," retinoic acid, and its role in both male and female meiotic initiation is thoughtfully critiqued (Chapter II). Second, 'RNA-binding motif protein 46' (RBM46) is characterized as an essential RNA-binding protein during the late stages of the mitotic spermatogonial differentiation program. In these male germ cells, RBM46 negatively regulates meiotic mRNAs, thus preventing precocious meiotic entry (Chapter III). Third and finally, translational efficiency of mRNAs in the whole testis is compared between mitotic and meiotic germ cells to identify novel genes that may be essential for the mitotic-to-meiotic transition (Chapter IV). Together, these works shed light on previously unappreciated and unexplored factors that allow male germ cells to enter meiosis, and ultimately, contribute to sustained fertility.;

653 a| spermatogenesis;

653 a| meiosis;

653 a| post-transcriptional control;

653 a| mitosis;

653 a| male germ cell;

700 1 a| Ph.D., Christopher Geyer,e| degree supervisor.;

710 2 a| East Carolina University;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/14765;

949 a| Click on web addressw| ASISh| JOYNER101;

949 a| Click on web addressw| ASISh| HSL111;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 6795434;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 6795434-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 7/29/2026x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 6795434-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 7/29/2026x| ETDz| HERESOURCE;

INVESTIGATING POST-TRANSCRIPTIONAL REGULATION OVER MRNA FATE ACROSS THE MITOTIC-TO-MEIOTIC TRANSITION IN MALE GERM CELLS

Author/creator	Gilbert, Emma Adeline author
Other author	Ph.D., Christopher Geyer, degree supervisor.
Other author	East Carolina University
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University 2026.]
Description	250 pages
Supplemental Content	Access via ScholarShip

Summary	Spermatogenesis requires carefully coordinated mRNA utilization throughout male germ cell development. Although it is recognized that post-transcriptional control of mRNAs is essential for spermatogenesis, little is known regarding how differential utilization of mRNAs results in successful entry of male germ cells into meiosis. The review (Chapter II) and studies (Chapters III-IV) included in the following dissertation seek to better understand the mechanisms that govern meiotic initiation. First, the current dogma surrounding the "meiosis-inducing substance," retinoic acid, and its role in both male and female meiotic initiation is thoughtfully critiqued (Chapter II). Second, 'RNA-binding motif protein 46' (RBM46) is characterized as an essential RNA-binding protein during the late stages of the mitotic spermatogonial differentiation program. In these male germ cells, RBM46 negatively regulates meiotic mRNAs, thus preventing precocious meiotic entry (Chapter III). Third and finally, translational efficiency of mRNAs in the whole testis is compared between mitotic and meiotic germ cells to identify novel genes that may be essential for the mitotic-to-meiotic transition (Chapter IV). Together, these works shed light on previously unappreciated and unexplored factors that allow male germ cells to enter meiosis, and ultimately, contribute to sustained fertility.
Dissertation note	Dr.Phil. East Carolina University 2026.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

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INVESTIGATING POST-TRANSCRIPTIONAL REGULATION OVER MRNA FATE ACROSS THE MITOTIC-TO-MEIOTIC TRANSITION IN MALE GERM CELLS

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