| Contents |
Part I Germline Syncytia, Evolution, Function, and Structure -- Chapter 1 The Ancient Origin and Function of Germline Cysts / Allan C. Spradling -- Chapter 2. Female Germline Cysts in Animals: Evolution and Function / Brubacher, John L. -- Chapter 3. Germline and Somatic Cell Syncytia in Insects / Malgorzata Kloc, Waclaw Tworzydlo, and Teresa Szklarzewicz -- Part II. Syncytia in Embryogenesis and Development -- Chapter 4. Reshaping the Syncytial Drosophila Embryo with Cortical Actin Networks: Four Main Steps of Early Development / Rebecca Tam and Tony J.C. Harris -- Chapter 5. Cell-Mediated Branch Fusion in the Drosophila Trachea / Lan Jiang -- Chapter 6. Trophoblast Syncytialization: A Metabolic Crossroads / Tina Podinić, Andie MacAndrew, and Sandeep Raha -- Chapter 7. Early Syncytialization of the Ovine Placenta Revisited / Heewon Seo, Fuller W. Bazer, and Gregory A. Johnson -- Chapter 8. Syncytia in Utricularia: Origin and Structure / Bartosz J. Plachno, Malgorzata Kapusta, and Pitor Świa̧tek -- Part III. Fungal and Somatic Cell Syncytia and Genomic View of Extremophiles as the Ancestral Precursors of Eukaryotic Syncytia -- Chapter 9. Syncytial Assembly Lines: Consequences of Multinucleate Cellular Compartments for Fungal Protein Synthesis / Alex Mayer, Grace McLaughlin, Amy Gladfelter, N. Louise Glass, Alexander Mela, and Marcus Roper -- Chapter 10. Ancestors in The Extreme: A Genomics View of Microbial Diversity in Hypersaline Aquatic Environments / Lulit Tilahun, Asfawossen Asrat, Gary M. Wessel, and Addis Simachew -- Chapter 11. Somatic Cell Fusion in Host Defense and Adaptation / Jeffrey L. Platt and Marilia Cascalho -- Chapter 12. Osteoclasts at Bone Remodeling: Order from Order / Jiro Takito and Naoko Nonaka -- Chapter 13. Muscle Progenitor Cell Fusion in the Maintenance of Skeletal Muscle / Jarred M. Whitlock -- Part IV. Virus- and Parasite- Induced Syncytia -- Chapter 14. Virus-Induced Cell Fusion and Syncytia Formation / Maorong Xie -- Chapter 15. HIV-1 Induced Cell-to-Cell Fusion or Syncytium Formation / Tobias Starling and Sergi Padilla-Parra -- Chapter 16. Relevance of the Entry by Fusion at the Cytoplasmic Membrane vs. Fusion After Endocytosis in the HIV and SARS-Cov-2 Infections / Leonor Huerta, Alejandro Gamboa-Meraz, and Pablo Samuel Estrada-Ochoa -- Chapter 17. Mathematical Modeling of Virus-Mediated Syncytia Formation: Past Successes and Future Directions / Hana M. Dobrovolny -- Chapter 18. Syncytium Induced by Plant-Parasitic Nematodes / Mateusz Matuszkiewicz and Miroslaw Sobczak -- Part V. Cell Fusion and Syncytia in Cancer -- Chapter 19. Mechanisms of Cell Fusion in Cancer / Felicite K. Noubissi, Oluwatoyin V. Odubanjo, Brenda M. Ogle, and Paul B. Tchounwou -- Chapter 20. Cell Fusion and Syncytia Formation in Cancer / Mareike Sieler and Thomas Dittmar -- Chapter 21. The Hallmarks of Circulating Hybrid Cells / Ranish K. Patel, Michael Parappilly, Shahrose Rahman, Isaac R. Schwantes, Marisa Sewell, Nicole R. Giske, Riley M. Whalen, Naside Godze Durmus, and Melissa H. Wong. |
| Abstract |
This book gives a current overview on the development, origin, structure, and functions of germline and somatic cell syncytia during embryogenesis and organogenesis. It also reviews pathogen-induced syncytia and the role of syncytial cells in cancer development. The book covers the following topics: germline syncytia, evolution, function and structure; syncytia in embryogenesis and development; the role of somatic cell fusion in fungi, specialized somatic tissues, host defense and adaptation; syncytia induced by viruses and parasites; syncytia and circulating hybrid cells in cancer and other pathological conditions; It also discusses how the genomic adaptations of microorganisms to extreme habitats can prompt the evolution of mononuclear and multinucleate/syncytial cells. The book offers a fresh outlook on syncytia's role in various processes: embryogenesis, organogenesis, adaptation, host defense, and development of specialized tissues. It highlights the importance of syncytia under physiological and pathological conditions. |
