Human iPSC-derived disease models for drug discovery / Markus H. Kuehn, Wei Zhu, editors.
| Other author | Kuehn, Markus H. |
| Other author | Zhu, Wei, Ph.D. |
| Format | Electronic |
| Publication Info | Cham, Switzerland : Springer, [2023] |
| Description | viii, 332 pages : illustrations, 24 cm. |
| Supplemental Content | Full text available from eBooks on EBSCOhost |
| Subjects |
| Series | Handbook of experimental pharmacology ; 0171-2004; volume 281 Handbook of experimental pharmacology ; v. 281. 0171-2004 |
| Contents | Part 1. iPSC production for pharmaceutical research. Human iPS for clinical applications and cellular products / Moyra Lawrence ; 3D-bioprinting of induced pluripotent stem cells and disease modeling / Shaojun Liang, Yijun Su, Rui Yao -- Part II. CNS iPSC and Oranioids. iPSCs-derived neurons and brain organoids from patients / Wanying Zhu, Lei Xu, Xinrui, Hao Hu, Shuning Lou, Yan Liu ; Retinal ganglion cells in a dish : current strategies and recommended best practices for effective in vitro modeling of development and disease / Kang-Chieh Huang, Cátia Gomes, Jason S. Meyer ; Applications of induced pluripotent stem cell-derived glia in brain disease research and treatment / Zhiqi Yang, Mingyue Gong, Chuanyan Yang, Chunhai Chen, Kuan Zhang ; Human-induced pluripotent stem cell-based model of the blood-brain at 10 years : a retrospective on past and current disease models / Abraham J. Al-Ahmad ; Human retinal organoids in therapeutic discovery : a review of applications / Lin Cheng, Markus H. Kuehn -- Part. III. iPSC-dreived nociceptive neurons. Using human iPSC-derived peripheral nervous system disease models for drug discovery / Yuan Gao -- Part IV. Non-neuronal specialized cell types. Human-induced pluripotent stem cell-based differentiation of cardiomyocyte subtypes for drug discovery and cell therapy / Ziwei Pan, Ping Liang ; Cardiac disease modeling with engineered heart tissue / Lin Cai, Ruxiang, Donghui Zhang ; iPSC-derived corneal endothelial cells / Qingjun Zhou, Zongyi Li, Haoyun Duan ; iPSCs-based therapy for trabecular meshwork / Wei Zhu, Xiaoyan Zhang, Shen Wu, Ningli Wang, Markus H. Kuehn ; Harnessing human pluripotent stem cell-derived pancreatic in vitro models for high-throughput toxicity testing and diabetes drug discovery / Carmen Ching, Elhadi Iich, Adrian Kee Keong Teo. |
| Abstract | Since their development a decade ago, human induced pluripotent stem cells (iPSC) have revolutionized the study of human disease, given rise to regenerative medicine technologies, and provided exceptional opportunities for pharmacologic research. These cells provide an essentially unlimited supply of cell types that are difficult to obtain from patients, such as neurons or cardiomyocytes, or are difficult to maintain in primary cell culture. iPSC can be obtained from patients afflicted with a particular disease but, in combination with recently developed gene editing techniques, can also be modified to generate disease models. Moreover, the new techniques of 3 Dimensional printing and materials science facilitate the generation of organoids that can mirror organs under disease conditions. These properties make iPSC powerful tools to study how diseases develop and how they may be treated. In addition, iPSC can also be used to treat conditions in which the target cell population has been lost and such regenerative approaches hold great promise for currently untreatable diseases, including cardiac failure or photoreceptor degenerations. |
| General note | Includes bibliographical references. |
| Access restriction | Available only to authorized users. |
| Technical details | Mode of access: World Wide Web |
| Genre/form | Electronic books. |
| ISBN | 9783031423482 |
| ISBN | 3031423488 |
| ISBN | ebook |
Availability
| Library | Location | Call Number | Status | Item Actions |
|---|---|---|---|---|
| Electronic Resources | Access Content Online | ✔ Available |