G protein-coupled receptors - modeling and simulation / Marta Filizola, editor.

Other author Filizola, Marta.
Format Electronic
Publication InfoDordrecht : Springer, [2014]
Descriptionviii, 228 pages : illustrations (some color) ; 26 cm.
Supplemental ContentFull text available from eBooks on EBSCOhost
Subjects
Receptors, G-Protein-Coupled
Computer Simulation

SeriesAdvances in experimental medicine and biology, 0065-2598 ; volume 796
Advances in experimental medicine and biology ; v. 796. 0065-2598
Contents pt. I. Progress in structural modeling of GPCRs -- The GPCR crystallography boom: providing an invaluable source of structural information and expanding the scope of homology modeling -- Modeling of G protein-coupled receptors using crystal structures: from monomers to signaling complexes -- pt. II. GPCRs in motion: insights from simulations -- Structure and dynamics of G-protein coupled receptors -- How the dynamic properties and functional mechanisms of GPCRs are modulated by their coupling to the membrane environment -- Coarse-grained molecular dynamics provides insights into the interactions of lipids and cholesterol with rhodopsin -- Beyond standard molecular dynamics: investigating the molecular mechanisms of G protein-coupled receptors with enhanced molecular dynamics methods -- pt. III. GPCR-focused design and mathematical modeling -- From three-dimensional GPCR structure to rational ligand discovery -- Mathematical modeling of G protein-coupled receptor function: what can we learn from empirical and mechanistic models? -- pt. IV. Bioinformatics tools and resources for GPCRs -- GPCR & company: databases and servers for GPCRs and interacting partners -- Bioinformatics tools for predicting GPCR gene functions.
Abstract "This book, which provides, for the first time, state-of-the-art views on modeling and simulation of GPCRs, is divided into 4 parts. In the first part, the impact of currently available GPCR crystal structures on structural modeling is discussed extensively as are critical insights from simulations in the second part of the book. The third part reports recent progress in rational ligand discovery and mathematical modeling, whereas the fourth part provides an overview of bioinformatics tools and resources that are available for GPCRs"--Publisher's website.
Bibliography noteIncludes bibliographical references and index.
Access restrictionAvailable only to authorized users.
Technical detailsMode of access: World Wide Web
Genre/formElectronic books.
LCCN 2013951640
ISBN9789400774223 hbk.
ISBN9400774222 hbk.
ISBNebook
ISBNebook

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