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020 a| 9783031300233q| (electronic bk.);

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024 7 a| 10.1007/978-3-031-30023-32| doi;

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245 00 a| Pharmaceutical biotechnology :b| fundamentals and applications /c| Daan J. A. Crommelin, Robert D. Sindelar, Bernd Meibohm, editors.;

250 a| 6th ed.;

260 a| Cham :b| Springer,c| 2024.;

300 a| 1 online resource (690 pages);

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505 00 g| Intro --g| Preface --g| Contents --g| Abbreviations --g| Part I:t| Pharmaceutical Biotechnology: The Science, Techniques, and Important Concepts --t| Molecular Biotechnology: From DNA Sequence to Therapeutic Protein --t| Biophysical and Biochemical Characteristics of Therapeutic Proteins --t| Stability and Characterization of Protein- and Nucleotide-Based Therapeutics --t| Production and Purification of Recombinant Proteins --t| Formulation of Biologics Including Biopharmaceutical Considerations --t| Pharmacokinetics and Pharmacodynamics of Therapeutic Proteins and Nucleic Acids --t| Immunogenicity of Therapeutic Proteins --t| Monoclonal Antibodies: From Structure to Therapeutic Application --t| Genomics, Other "OMIC" Technologies, Precision Medicine, and Additional Biotechnology-Related Techniques --t| Economic Considerations in Medical Biotechnology --t| Biosimilars: Principles, Regulatory Framework, and Societal Aspects --t| An Evidence-Based Practice Approach to Evaluating Biotechnologically Derived Medications --g| Part II:t| Pharmaceutical Biotechnology: Oligonucleotides, Genes and Cells/Cell Subunits, Vaccines--The Science, Techniques, and Clinical Use --t| Oligonucleotides and mRNA Therapeutics --t| Oligonucleotides and mRNA Therapeutics --t| Vaccines --g| Part III:t| Pharmaceutical Biotechnology: The Protein Products of Biotechnology and Their Clinical Use--Endogenous Proteins and Their Variations --t| Insulin --t| Hematopoietic Growth Factors --t| Recombinant Coagulation Factors and Thrombolytic Agents --t| Follicle-Stimulating Hormone --t| Human Growth Hormone --t| Recombinant Human Deoxyribonuclease I --t| Interferons and Interleukins --g| Part IV:t| Pharmaceutical Biotechnology: The Protein Products of Biotechnology and Their Clinical Use--Monoclonal Antibodies and Their Variations --t| Antibody-Based Biotherapeutics in Cancer --t| Antibody-Based Biotherapeutics in Inflammatory Diseases --t| Monoclonal Antibodies in Solid Organ Transplantation --t| Antibody-Based Biotherapeutics in Migraine --g| Back Matter.;

500 a| Higher Order Structure Modifications in Nucleotide-Based Pharmaceuticals;

520 a| This introductory text explains both the basic science, production, quality, dosage forms, administration, economic and regulatory aspects and the clinical applications of biotechnology-derived pharmaceuticals. It serves as a complete one-stop source for undergraduate/graduate pharmacists and pharmaceutical science students. An additional important audience are pharmaceutical scientists in industry and academia, particularly those who have not received formal training in pharmaceutical biotechnology and are inexperienced in this field. The rapid growth and advances in the field made it necessary to revise this textbook in order to continue providing up-to-date information and introduce readers to cutting edge knowledge and technology of this field. This Sixth Edition completely updates the previous edition and includes additional coverage on new approaches such as oligonucleotides, siRNA, mRNA, gene therapy, cell therapies, monoclonal antibodies and vaccines. With more than 3-million-chapter downloads, the fifth edition of the textbook has achieved widespread distribution as a key educational resource for the field of pharmaceutical biotechnology.;

588 0 a| Online resource; title from PDF title page (SpringerLink, viewed February 14, 2024).;

650 0 a| Pharmaceutical biotechnology.=| ^A492454;

650 0 a| Pharmaceutical technology.=| ^A234566;

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700 1 a| Crommelin, D. J. A.q| (Daan J. A.)=| ^A936956;

700 1 a| Sindelar, Robert D.=| ^A936957;

700 1 a| Meibohm, Bernd.=| ^A995983;

856 40 z| Direct link to eBooku| https://ebookcentral.proquest.com/lib/eastcarolina/detail.action?docID=31095553;

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Pharmaceutical biotechnology : fundamentals and applications / Daan J. A. Crommelin, Robert D. Sindelar, Bernd Meibohm, editors.

Other author	Crommelin, D. J. A. (Daan J. A.)
Other author	Sindelar, Robert D.
Other author	Meibohm, Bernd.
Format	Electronic
Edition	6th ed.
Publication Info	Cham : Springer, 2024.
Description	1 online resource (690 pages)
Supplemental Content	Direct link to eBook
Subjects	Pharmaceutical biotechnology. Pharmaceutical technology. Technology, Pharmaceutical.

Contents	Intro -- Preface -- Contents -- Abbreviations -- Part I: Pharmaceutical Biotechnology: The Science, Techniques, and Important Concepts -- Molecular Biotechnology: From DNA Sequence to Therapeutic Protein -- Biophysical and Biochemical Characteristics of Therapeutic Proteins -- Stability and Characterization of Protein- and Nucleotide-Based Therapeutics -- Production and Purification of Recombinant Proteins -- Formulation of Biologics Including Biopharmaceutical Considerations -- Pharmacokinetics and Pharmacodynamics of Therapeutic Proteins and Nucleic Acids -- Immunogenicity of Therapeutic Proteins -- Monoclonal Antibodies: From Structure to Therapeutic Application -- Genomics, Other "OMIC" Technologies, Precision Medicine, and Additional Biotechnology-Related Techniques -- Economic Considerations in Medical Biotechnology -- Biosimilars: Principles, Regulatory Framework, and Societal Aspects -- An Evidence-Based Practice Approach to Evaluating Biotechnologically Derived Medications -- Part II: Pharmaceutical Biotechnology: Oligonucleotides, Genes and Cells/Cell Subunits, Vaccines--The Science, Techniques, and Clinical Use -- Oligonucleotides and mRNA Therapeutics -- Oligonucleotides and mRNA Therapeutics -- Vaccines -- Part III: Pharmaceutical Biotechnology: The Protein Products of Biotechnology and Their Clinical Use--Endogenous Proteins and Their Variations -- Insulin -- Hematopoietic Growth Factors -- Recombinant Coagulation Factors and Thrombolytic Agents -- Follicle-Stimulating Hormone -- Human Growth Hormone -- Recombinant Human Deoxyribonuclease I -- Interferons and Interleukins -- Part IV: Pharmaceutical Biotechnology: The Protein Products of Biotechnology and Their Clinical Use--Monoclonal Antibodies and Their Variations -- Antibody-Based Biotherapeutics in Cancer -- Antibody-Based Biotherapeutics in Inflammatory Diseases -- Monoclonal Antibodies in Solid Organ Transplantation -- Antibody-Based Biotherapeutics in Migraine -- Back Matter.
Abstract	This introductory text explains both the basic science, production, quality, dosage forms, administration, economic and regulatory aspects and the clinical applications of biotechnology-derived pharmaceuticals. It serves as a complete one-stop source for undergraduate/graduate pharmacists and pharmaceutical science students. An additional important audience are pharmaceutical scientists in industry and academia, particularly those who have not received formal training in pharmaceutical biotechnology and are inexperienced in this field. The rapid growth and advances in the field made it necessary to revise this textbook in order to continue providing up-to-date information and introduce readers to cutting edge knowledge and technology of this field. This Sixth Edition completely updates the previous edition and includes additional coverage on new approaches such as oligonucleotides, siRNA, mRNA, gene therapy, cell therapies, monoclonal antibodies and vaccines. With more than 3-million-chapter downloads, the fifth edition of the textbook has achieved widespread distribution as a key educational resource for the field of pharmaceutical biotechnology.
General note	Higher Order Structure Modifications in Nucleotide-Based Pharmaceuticals
Source of description	Online resource; title from PDF title page (SpringerLink, viewed February 14, 2024).
Issued in other form	Print version: Crommelin, Daan J. A. Pharmaceutical Biotechnology Cham : Springer International Publishing AG,c2024 9783031300226
ISBN	9783031300233 (electronic bk.)
ISBN	3031300238 (electronic bk.)
Standard identifier#	10.1007/978-3-031-30023-3

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Pharmaceutical biotechnology : fundamentals and applications / Daan J. A. Crommelin, Robert D. Sindelar, Bernd Meibohm, editors.

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