Quantitative methods for precision medicine pharmacogenomics in action / Rongling Wu (the Pennsylvania State University, USA) ; with contributions from Mengmeng Sang (Institute of Reproductive Medicine, Nantong University Medical School, China), Feng Li (Centre for Computational Biology, College of Biological Science and Technologies, Beijing Forestry University, China).
| Author/creator | Wu, Rongling |
| Other author | Sang, Mengmeng. |
| Other author | Li, Feng (Computational biologist) |
| Format | Electronic |
| Edition | First edition. |
| Publication Info | Boca Raton : C&H/CRC Press, 2023. |
| Description | 1 online resource. |
| Supplemental Content | Full text available from Taylor & Francis eBooks |
| Subjects |
| Series | Chapman & Hall/CRC biostatistics series |
| Abstract | "Modern medicine is undergoing a paradigm shift from a "one-size-fits-all" strategy to a more precise patient-customized therapy and medication plan. While the success of precision medicine relies on the level of pharmacogenomic knowledge, dissecting the genetic mechanisms of drug response in a sufficient detail requires powerful computational tools. Quantitative Methods for Precision Medicine: Pharmacogenomics in Action presents the advanced statistical methods for mapping pharmacogenetic control by integrating pharmacokinetic and pharmacodynamic principles of drug-body interactions. Beyond traditional reductionist-based statistical genetic approaches, statistical formulization in this book synthesizes elements of multiple disciplines to infer, visualize, and track how pharmacogenes interact together as an intricate but well-coordinated system to mediate patient-specific drug response. Features: Functional and systems mapping models to characterize the genetic architecture of multiple medication processes Statistical methods for analyzing informative missing data in pharmacogenetic association studies Functional graph theory of inferring genetic interaction networks from association data Leveraging the concept of epistasis to capture its bidirectional, signed and weighted properties Modeling gene-induced cell-cell crosstalk and its impact on drug response A graph model of drug-drug interactions in combination therapies Critical methodological issues to improve pharmacogenomic research as the cornerstone of precision medicine This book is suitable for graduate students and researchers in the field of biology, medicine, bioinformatics and drug design and delivery interested in statistical and computational modelling of biological processes and systems. It may also serve as a major reference for applied mathematicians, computer scientists, and statisticians who attempt to develop algorithmic tools for genetic mapping, systems pharmacogenomics and systems biology. It can be used as both a textbook and research reference. It can also be used by professionals in pharmaceutical sectors who design drugs and by clinical doctors who deliver drugs"-- Provided by publisher. |
| Bibliography note | Includes bibliographical references and index. |
| Access restriction | Available only to authorized users. |
| Technical details | Mode of access: World Wide Web |
| Source of description | Description based on print version record. |
| Issued in other form | Print version: Wu, Rongling. Quantitative methods for precision medicine First edition. Boca Raton : C&H/CRC Press, 2023 9781482219456 |
| Genre/form | Electronic books. |
| LCCN | 2022030450 |
| ISBN | 9780429171512 (ebook) |
| ISBN | (hardback) |
| ISBN | (paperback) |
Availability
| Library | Location | Call Number | Status | Item Actions |
|---|---|---|---|---|
| Electronic Resources | Access Content Online | ✔ Available |