Therapeutic applications of quadruplex nucleic acids / Stephen Neidle.

Author/creator Neidle, Stephen
Format Electronic
Edition1st ed.
Publication InfoLondon ; Waltham, MA : Elsevier/Academic Press,
Descriptionxii, 196 p. : ill. ; 24 cm.
Supplemental ContentFull text available from eBook - Biochemistry, Genetics and Molecular Biology 2011
Subjects
Quadruplex nucleic acids--Therapeutic use.
G-Quadruplexes.
Antineoplastic Agents--therapeutic use.
Antineoplastic Agents--pharmacology.
Neoplasms--drug therapy.
Nucleic Acid Conformation.
Telomere--chemistry.

Contents Introduction: quadruplexes and their biology -- DNA and RNA quadruplex structures -- The structures of human telomeric DNA quadruplexes -- Telomeric quadruplex ligands I: anthraquinones and acridines -- Telomeric quadruplex ligands II: polycyclic and non-fused ring compounds -- The biology and pharmacology of telomeric quadruplex ligands -- Genomic quadruplexes as therapeutic targets -- RNA quadruplexes -- Design principles for quadruplex-binding small molecules -- The determination of quadruplex structures.
Abstract "Therapeutic applications of quadruplex nucleic acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics"--P. [4] of cover.
Bibliography noteIncludes bibliographical references and index.
Access restrictionAvailable only to authorized users.
Technical detailsMode of access: World Wide Web
Genre/formElectronic books.
LCCN 2011293620
ISBN9780123751386 (hbk)
ISBN0123751381 (hbk)

Availability

Library Location Call Number Status Item Actions
Electronic Resources Access Content Online ✔ Available