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035 a| (Sirsi) o42011455;

035 a| (OCoLC)42011455;

049 a| EREE;

050 4 a| QL638.M678b| S63 1998;

100 1 a| Snell, Elizabeth Ann,e| author.?| UNAUTHORIZED;

245 10 a| Genomic organization of the Hoxa4-a10 region from Morone saxatilis (striped bass) :b| macroevolutionary changes of the Hoxa gene cluster among vertebrates /c| by Elizabeth Ann Snell.;

264 0 c| 1998.;

300 a| xiii, 166 leaves :b| illustrations ;c| 28 cm;

336 a| textb| txt2| rdacontent;

337 a| unmediatedb| n2| rdamedia;

338 a| volumeb| nc2| rdacarrier;

502 b| M.S.c| East Carolina Universityd| 1998;

500 a| Submitted to the faculty of the Department of Biology.;

500 a| Advisor: Edmund J. Stellwag;

520 3 a| Studies of vertebrate Hox cluster evolution in the cephalochordate amphioxus and select vertebrates have shown an increase in cluster number among vertebrates, punctuated by lineage-specific gene loss events. I have sequenced a 31 kb region of the HoxA cluster from the teleost Morone saxatilis (striped bass), to provide a detailed physical map of this region, and to examine macroevolutionary changes of vertebrate Hox clusters. I identified five linked Hox genes: Hoxa4, HoxaS, Hoxa7, Hoxa9, and HoxalO, which are organized similarly to those of other vertebrates. Furthermore, I have documented the absence of the Hoxa6 and HoxaS genes within the 31 kb contig. Comparison of these results to those published for other vertebrates show that among the genes of the Hoxa4-al0 region in vertebrates, genes HoxaS, Hoxa7, Hoxa9 and HoxalO are common to all vertebrates. I have also determined that the absence of Hoxa6 is a common characteristic of teleosts, whereas the absence of HoxaS is common to vertebrates in general, with the possible exception of zebrafish. These results suggest that there are lineage-specific differences in the HoxA complement of vertebrates, and particularly among the teleosts. Further comparisons of the genomic sequences obtained in this study to PCR-derived Hox gene sequences from M. saxatilis and other teleosts provide evidence that PCR-based surveys of conserved gene families such as the homeobox-encoding genes, can be inconclusive. Comparisons of the Hox cluster intergenic regions among vertebrates revealed extensive conservation of the non-coding intergenic regions between closely related orders, but an overall absence of sequence relatedness between phylogenetically disparate species. In addition to the lineage specific-gene alterations and variation within the intergenic regions, I also documented marked reduction in the length of the Hoxa4-al0 region between vertebrate lineages representative of teleosts and mammals. Comparative analysis of HoxA cluster organization among teleosts and mammals suggests that cluster length reduction and lineage-specific gene loss events are characteristic of Hox cluster evolution.;

504 a| Includes bibliographical references (leaves 71-76).;

650 0 a| Striped bassx| Genetics.=| ^A69980;

650 0 a| DNAx| Analysis.=| ^A13543;

650 0 a| Gene mapping.=| ^A137648;

650 2 a| Chromosome Mapping.0| (DNLM)D002874=| ^A922405;

655 2 a| Academic Dissertation.0| (DNLM)D019478?| UNAUTHORIZED;

650 7 a| DNAx| Analysis.2| fast0| (OCoLC)fst00886556;

650 7 a| Gene mapping.2| fast0| (OCoLC)fst00939625;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

700 1 a| Stellwag, Edmund J.q| (Edmund Johannes),d| 1951-e| degree supervisor.1| https://id.oclc.org/worldcat/entity/E39PCjxw8WYhVjjbHqyXbxhXMP=| ^A1031239;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 41 z| Access via ScholarShipu| http://hdl.handle.net/10342/11488;

949 a| Click on web addressw| asish| joyner101;

949 a| Click on web addressw| asish| hsl111;

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Genomic organization of the Hoxa4-a10 region from Morone saxatilis (striped bass) : macroevolutionary changes of the Hoxa gene cluster among vertebrates / by Elizabeth Ann Snell.

Author/creator	Snell, Elizabeth Ann author.
Other author	Stellwag, Edmund J. (Edmund Johannes), 1951- degree supervisor.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Production	1998.
Description	xiii, 166 leaves : illustrations ; 28 cm
Supplemental Content	Access via ScholarShip
Subjects	Striped bass--Genetics. DNA--Analysis. Gene mapping. Chromosome Mapping.

Summary	Studies of vertebrate Hox cluster evolution in the cephalochordate amphioxus and select vertebrates have shown an increase in cluster number among vertebrates, punctuated by lineage-specific gene loss events. I have sequenced a 31 kb region of the HoxA cluster from the teleost Morone saxatilis (striped bass), to provide a detailed physical map of this region, and to examine macroevolutionary changes of vertebrate Hox clusters. I identified five linked Hox genes: Hoxa4, HoxaS, Hoxa7, Hoxa9, and HoxalO, which are organized similarly to those of other vertebrates. Furthermore, I have documented the absence of the Hoxa6 and HoxaS genes within the 31 kb contig. Comparison of these results to those published for other vertebrates show that among the genes of the Hoxa4-al0 region in vertebrates, genes HoxaS, Hoxa7, Hoxa9 and HoxalO are common to all vertebrates. I have also determined that the absence of Hoxa6 is a common characteristic of teleosts, whereas the absence of HoxaS is common to vertebrates in general, with the possible exception of zebrafish. These results suggest that there are lineage-specific differences in the HoxA complement of vertebrates, and particularly among the teleosts. Further comparisons of the genomic sequences obtained in this study to PCR-derived Hox gene sequences from M. saxatilis and other teleosts provide evidence that PCR-based surveys of conserved gene families such as the homeobox-encoding genes, can be inconclusive. Comparisons of the Hox cluster intergenic regions among vertebrates revealed extensive conservation of the non-coding intergenic regions between closely related orders, but an overall absence of sequence relatedness between phylogenetically disparate species. In addition to the lineage specific-gene alterations and variation within the intergenic regions, I also documented marked reduction in the length of the Hoxa4-al0 region between vertebrate lineages representative of teleosts and mammals. Comparative analysis of HoxA cluster organization among teleosts and mammals suggests that cluster length reduction and lineage-specific gene loss events are characteristic of Hox cluster evolution.
General note	Submitted to the faculty of the Department of Biology.
General note	Advisor: Edmund J. Stellwag
Dissertation note	M.S. East Carolina University 1998
Bibliography note	Includes bibliographical references (leaves 71-76).
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

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Genomic organization of the Hoxa4-a10 region from Morone saxatilis (striped bass) : macroevolutionary changes of the Hoxa gene cluster among vertebrates / by Elizabeth Ann Snell.

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