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010 a| 2017004759;

020 a| 9780190687762 (hardback);

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049 a| EREEa| NEHH;

050 00 a| RD549b| .H38 2018;

082 00 a| 617.5/8105922| 23;

100 1 a| Harris, William H.q| (William Hamilton),d| 1927-=| ^A800865;

245 10 a| Vanishing boneh| [electronic resource] :b| conquering a stealth disease caused by total hip replacements /c| William H. Harris, MD, DSc.;

260 a| New York, NY :b| Oxford University Press,c| [2018];

300 a| xxii, 219 pages :b| illustrations ;c| 22 cm;

504 a| Includes bibliographical references and index.;

506 a| Available only to authorized users.;

520 a| " When dozens of holes appeared in a patient's femur alongside his hip prosthesis, experts were baffled as such a phenomenon had never been seen before. Over the first four decades of total hip surgery, the severe bone destruction multiplied, crippling many thousands of patients. Eventually identified as "periprosthetic osteolysis," this devastating disease affected over 1 million patients and was the leading cause of failure in total hip surgery. While total hip surgery dramatically reversed severe arthritis of the hip, the same operation simultaneously created a relentless 'particle generator' in the body. Ironically, in the effort to do good, doctors were simultaneously doing major harm. Vanishing Bone : Conquering a Stealth Disease Caused by Total Hip Replacements takes readers on a detective adventure in contemporary medical science, from the identification of the cause of the disease through the complex process of affecting its cure. Dr. William H. Harris and his colleagues played an important role in solving the mystery of this disease, pointing to its molecular biology, recognizing the unusual wear of the prostheses, and ultimately developing a new material for use in the manufacture of hip implants. With more than 6 million people walking on this stable, low-wear material, the disease has been virtually eliminated among those with total hip replacements worldwide. Diseases are rarely observed, revealed, and eliminated in one lifetime. Vanishing Bone tells the captivating story of one such disease through an engaging account of scientific and medical innovation."--c| Provided by publisher.;

538 a| Mode of access: World Wide Web;

650 0 a| Total hip replacement.=| ^A670366;

650 0 a| Bone resoption.?| UNAUTHORIZED;

655 0 a| Electronic books.=| ^A491897;

856 40 z| Full text available from Ebook Central - Academic Completeu| https://ebookcentral.proquest.com/lib/eastcarolina/detail.action?docID=5160913;

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Vanishing bone conquering a stealth disease caused by total hip replacements / William H. Harris, MD, DSc.

Author/creator	Harris, William H., 1927-
Format	Electronic
Publication Info	New York, NY : Oxford University Press, [2018]
Description	xxii, 219 pages : illustrations ; 22 cm
Supplemental Content	Full text available from Ebook Central - Academic Complete
Subjects	Total hip replacement. Bone resoption.

Abstract	" When dozens of holes appeared in a patient's femur alongside his hip prosthesis, experts were baffled as such a phenomenon had never been seen before. Over the first four decades of total hip surgery, the severe bone destruction multiplied, crippling many thousands of patients. Eventually identified as "periprosthetic osteolysis," this devastating disease affected over 1 million patients and was the leading cause of failure in total hip surgery. While total hip surgery dramatically reversed severe arthritis of the hip, the same operation simultaneously created a relentless 'particle generator' in the body. Ironically, in the effort to do good, doctors were simultaneously doing major harm. Vanishing Bone : Conquering a Stealth Disease Caused by Total Hip Replacements takes readers on a detective adventure in contemporary medical science, from the identification of the cause of the disease through the complex process of affecting its cure. Dr. William H. Harris and his colleagues played an important role in solving the mystery of this disease, pointing to its molecular biology, recognizing the unusual wear of the prostheses, and ultimately developing a new material for use in the manufacture of hip implants. With more than 6 million people walking on this stable, low-wear material, the disease has been virtually eliminated among those with total hip replacements worldwide. Diseases are rarely observed, revealed, and eliminated in one lifetime. Vanishing Bone tells the captivating story of one such disease through an engaging account of scientific and medical innovation."-- Provided by publisher.
Bibliography note	Includes bibliographical references and index.
Access restriction	Available only to authorized users.
Technical details	Mode of access: World Wide Web
Genre/form	Electronic books.
LCCN	2017004759
ISBN	9780190687762 (hardback)

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Vanishing bone conquering a stealth disease caused by total hip replacements / William H. Harris, MD, DSc.

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