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007 cr unu||||||||;

008 240916s2024 ncua obm 000 0 eng d;

035 a| (OCoLC)1456021919;

090 a| RA644.C67;

049 a| EREE;

100 1 a| Wright, Raegynn E.,e| author.?| UNAUTHORIZED;

245 10 a| Investigating the role of viral proteins in COVID-19 blood clotting /c| by Raegynn E. Wright.;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2024.;

300 a| 1 online resources (43 pages) :b| illustrations (chiefly color);

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text fileb| application/pdfc| 814.58 KB2| rda;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| M.S.c| East Carolina Universityd| 2024.;

500 a| Presented to the Faculty of the Department of Biology;

500 a| Advisor: Eric Anderson;

500 a| Title from PDF t.p. (viewed November 11, 2025).;

520 3 a| There have been approximately 7 million deaths and 775,522,404 infections worldwide due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Many of the severe symptoms of COVID infection are associated with blood clot formation during infection. Post-Acute Sequel of COVID is also associated with symptoms that are hypothesized to be the result of clotting as well. Clot formation is a natural response to cellular damage within the vascular system and is facilitated by the release of a series of fiber-like structures known as Von Willebrand Factor (VWF). To prevent unnecessary clots from forming during vascular inflammation, an enzyme called ADAMTS-13 prevents the accumulation of VWF, in the absence of serious cell damage. This paper demonstrates that a viral protein capable of cleaving ADAMTS-13 may be responsible for the reduced levels of ADAMTS-13 noted in COVID-19 patients that is linked to increased clot formation during infection. Additionally, this interaction may provide insights into the rebound symptoms observed with the anti-COVID drug Paxlovid, a 3CL protease inhibitor, and provide clues to the nature of symptoms associated with, and potential diagnostic tools for long COVID.;

504 a| Includes bibliographical references.;

650 0 a| COVID-19 (Disease)x| Complications.=| ^A1452338;

650 0 a| Blood coagulation factors.=| ^A13591;

650 0 a| Von Willebrand factor.=| ^A1486501;

650 0 a| Viral proteins.=| ^A400169;

653 a| Blood clotting;

653 a| ADAMTS-13;

700 1 a| Anderson, Eric,e| degree supervisor.=| ^A696706;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/13691;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 6477438;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 6477438-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 9/16/2024x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 6477438-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 9/16/2024x| ETDz| HERESOURCE;

Investigating the role of viral proteins in COVID-19 blood clotting / by Raegynn E. Wright.

Author/creator	Wright, Raegynn E. author.
Other author	Anderson, Eric, degree supervisor.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2024.
Description	1 online resources (43 pages) : illustrations (chiefly color)
Supplemental Content	Access via ScholarShip
Subjects	COVID-19 (Disease)--Complications. Blood coagulation factors. Von Willebrand factor. Viral proteins.

Summary	There have been approximately 7 million deaths and 775,522,404 infections worldwide due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Many of the severe symptoms of COVID infection are associated with blood clot formation during infection. Post-Acute Sequel of COVID is also associated with symptoms that are hypothesized to be the result of clotting as well. Clot formation is a natural response to cellular damage within the vascular system and is facilitated by the release of a series of fiber-like structures known as Von Willebrand Factor (VWF). To prevent unnecessary clots from forming during vascular inflammation, an enzyme called ADAMTS-13 prevents the accumulation of VWF, in the absence of serious cell damage. This paper demonstrates that a viral protein capable of cleaving ADAMTS-13 may be responsible for the reduced levels of ADAMTS-13 noted in COVID-19 patients that is linked to increased clot formation during infection. Additionally, this interaction may provide insights into the rebound symptoms observed with the anti-COVID drug Paxlovid, a 3CL protease inhibitor, and provide clues to the nature of symptoms associated with, and potential diagnostic tools for long COVID.
General note	Presented to the Faculty of the Department of Biology
General note	Advisor: Eric Anderson
General note	Title from PDF t.p. (viewed November 11, 2025).
Dissertation note	M.S. East Carolina University 2024.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

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Investigating the role of viral proteins in COVID-19 blood clotting / by Raegynn E. Wright.

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