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035 a| (Sirsi) o39552118;

035 a| (OCoLC)39552118;

049 a| EREE;

050 4 a| RC641.7.S5b| W55 1998;

100 1 a| Williams, Isha D.,e| author.?| UNAUTHORIZED;

245 10 a| Plasma l-arginine is low in sickle cell anemia :b| evidence based on a new colorimetric method /c| by Isha D. Williams.;

264 0 c| 1998.;

300 a| vii, 44 leaves :b| illustrations ;c| 28 cm;

336 a| textb| txt2| rdacontent;

337 a| unmediatedb| n2| rdamedia;

338 a| volumeb| nc2| rdacarrier;

502 b| M.S.c| East Carolina Universityd| 1998;

500 a| Submitted to the faculty of the Department of Biology.;

500 a| Advisor: William H. Waugh;

520 3 a| The Sickle Cell Diseases (SCD) are a group of disorders characterized by abnormal hemoglobin, the primary protein in blood. The disorder most often involves a specific site on the beta globin chain. In sickle cell anemia, a point mutation occurs, changing the beta 6 residue of glutamic acid to valine. This results in sickle cell homozygous anemia (HbSS). Nutrition plays an important role in the health of a sickle cell anemia individual. A proper diet ensures the essential amino acids and vitamins are made available to the body. The amino acid L-arginine is usually considered a nonessential amino acid in the diets of humans. L-arginine, however, is the specific precursor to nitric oxide utilized in the body to mediate adequate vasodilator function. In extremely stressful conditions, a deficiency can be created if the nutritional or endogenous sources of L-arginine are depleted. One such stressful condition is a sickle cell anemia crisis. It has recently been suggested that L-arginine may become a conditionally indispensable amino acid in sickle cell anemia. A micro colorimetric method for a quantitative assay of L-arginine will allow for the determination of the plasma levels of L-arginine. The objective of this research is to provide evidence, through the use of a new micro colorimetric method for a quantitative assay of plasma L-arginine, to further the hypothesis that L-arginine may become a conditionally indispensable amino acid in sickle cell anemia.;

504 a| Includes bibliographical references (leaves 36-39).;

650 0 a| Sickle cell anemia.=| ^A293023;

650 0 a| Blood plasmax| Analysis.=| ^A250791;

650 2 a| Anemia, Sickle Cell.0| (DNLM)D000755=| ^A919757;

655 2 a| Academic Dissertation.0| (DNLM)D019478?| UNAUTHORIZED;

650 7 a| Blood plasmax| Analysis.2| fast0| (OCoLC)fst00834776;

650 7 a| Sickle cell anemia.2| fast0| (OCoLC)fst01118092;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

700 1 a| Waugh, William H.,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Departments of Physiology and Biology.?| UNAUTHORIZED;

856 41 z| Access via ScholarShipu| http://hdl.handle.net/10342/12915;

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Plasma l-arginine is low in sickle cell anemia : evidence based on a new colorimetric method / by Isha D. Williams.

Author/creator	Williams, Isha D. author.
Other author	Waugh, William H., degree supervisor.
Other author	East Carolina University. Departments of Physiology and Biology.
Format	Theses and dissertations
Production	1998.
Description	vii, 44 leaves : illustrations ; 28 cm
Supplemental Content	Access via ScholarShip
Subjects	Sickle cell anemia. Blood plasma--Analysis. Anemia, Sickle Cell.

Summary	The Sickle Cell Diseases (SCD) are a group of disorders characterized by abnormal hemoglobin, the primary protein in blood. The disorder most often involves a specific site on the beta globin chain. In sickle cell anemia, a point mutation occurs, changing the beta 6 residue of glutamic acid to valine. This results in sickle cell homozygous anemia (HbSS). Nutrition plays an important role in the health of a sickle cell anemia individual. A proper diet ensures the essential amino acids and vitamins are made available to the body. The amino acid L-arginine is usually considered a nonessential amino acid in the diets of humans. L-arginine, however, is the specific precursor to nitric oxide utilized in the body to mediate adequate vasodilator function. In extremely stressful conditions, a deficiency can be created if the nutritional or endogenous sources of L-arginine are depleted. One such stressful condition is a sickle cell anemia crisis. It has recently been suggested that L-arginine may become a conditionally indispensable amino acid in sickle cell anemia. A micro colorimetric method for a quantitative assay of L-arginine will allow for the determination of the plasma levels of L-arginine. The objective of this research is to provide evidence, through the use of a new micro colorimetric method for a quantitative assay of plasma L-arginine, to further the hypothesis that L-arginine may become a conditionally indispensable amino acid in sickle cell anemia.
General note	Submitted to the faculty of the Department of Biology.
General note	Advisor: William H. Waugh
Dissertation note	M.S. East Carolina University 1998
Bibliography note	Includes bibliographical references (leaves 36-39).
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

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Plasma l-arginine is low in sickle cell anemia : evidence based on a new colorimetric method / by Isha D. Williams.

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