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LEADER 04583ctm a2200637 i 4500

001 ocm39487096;

003 OCoLC;

005 20241021155025.0;

008 980715s1997 xx a bm 000 0 eng d;

035 a| (Sirsi) o39487096;

035 a| (OCoLC)39487096;

049 a| EREE;

050 4 a| QL638.P358b| G54 1997;

100 1 a| Giesler, Thomas A.,e| author.?| UNAUTHORIZED;

245 10 a| DNA sequence analysis of two Hox genes in the teleost Morone saxatilis :b| implications for the evolution of the Hox gene family in vertebrates /c| by Thomas A. Giesler.;

264 0 c| 1997.;

300 a| 74 leaves :b| illustrations ;c| 28 cm;

336 a| textb| txt2| rdacontent;

337 a| unmediatedb| n2| rdamedia;

338 a| volumeb| nc2| rdacarrier;

502 b| M.S.c| East Carolina Universityd| 1997;

500 a| Submitted to the faculty of the Department of Biology.;

500 a| Advisor: Edmund J. Stellwag;

520 3 a| Biologists have long be interested in systems that are responsible for the regulation of development and how they evolved. Of great importance in this regard is the discovery of the vertebrate Hox genes, a group of genes responsible for embryonic development. Hybridization analysis of numerous vertebrate and invertebrate species has revealed the presence of Hox genes in each of the organisms studied, indicating that this class of genes is evolutionarily ancient. In mammals Hox genes are located on separate chromosomes in four distinct clusters, in which the clusters are presumed to have been derived from the duplication of a single ancestral cluster. The purpose of this investigation was to determine if Morone saxatilis (striped bass), a nonmammalian vertebrate, has a similar complement and organization of Hox genes to that of the mammals. We obtained the complete DNA sequence from a bacteriophage lambda-EMBL 3 derived clone prepared from Morone saxatilis genomic DNA. Clone 7H was found to contain two Hox genes, located approximately 7.5kb apart. These two genes were found to be homologous to the known mammalian Hox genes HoxA5 and HoxA7, and were located on the clone in the same order relative to each other as HoxA5 and HoxA7 are in the mammals. Despite the linkage of Morone saxatilis HoxA5 and HoxA7 genes, I was unable to identify a gene corresponding to HoxA6 in the intergenic region between HoxAS and HoxA7. The apparent absence of a HoxA6 gene in the region between HoxA5 and HoxA7 in Morone saxatilis, a representative of the perciform fish, demonstrates that Hox gene evolution in this teleost differs from that in other characterized vertebrates.;

504 a| Includes bibliographical references (leaves 34-40).;

650 0 a| Striped bass.=| ^A69980;

650 0 a| Genetic regulation.=| ^A6251;

650 0 a| DNAx| Analysis.=| ^A13543;

650 0 a| Embryonic periodicity.=| ^A401144;

650 0 a| Gene expression.=| ^A6250;

650 0 a| Gene mapping.=| ^A137648;

650 2 a| Gene Expression Regulation.0| (DNLM)D005786=| ^A920642;

650 2 a| Gene Expression.0| (DNLM)D015870=| ^A919546;

650 2 a| Chromosome Mapping.0| (DNLM)D002874=| ^A922405;

655 2 a| Academic Dissertation.0| (DNLM)D019478?| UNAUTHORIZED;

650 7 a| DNAx| Analysis.2| fast0| (OCoLC)fst00886556;

650 7 a| Embryonic periodicity.2| fast0| (OCoLC)fst00908442;

650 7 a| Gene expression.2| fast0| (OCoLC)fst00939613;

650 7 a| Gene mapping.2| fast0| (OCoLC)fst00939625;

650 7 a| Genetic regulation.2| fast0| (OCoLC)fst00940086;

650 7 a| Striped bass.2| fast0| (OCoLC)fst01135489;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

700 1 a| Stellwag, Edmund J.q| (Edmund Johannes),d| 1951-e| degree supervisor.=| ^A1031239;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 41 z| Access via ScholarShipu| http://hdl.handle.net/10342/11998;

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949 a| Click on web addressw| asish| hsl111;

994 a| C0b| ERE;

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DNA sequence analysis of two Hox genes in the teleost Morone saxatilis : implications for the evolution of the Hox gene family in vertebrates / by Thomas A. Giesler.

Author/creator	Giesler, Thomas A. author.
Other author	Stellwag, Edmund J. (Edmund Johannes), 1951- degree supervisor.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Production	1997.
Description	74 leaves : illustrations ; 28 cm
Supplemental Content	Access via ScholarShip
Subjects	Striped bass. Genetic regulation. DNA--Analysis. Embryonic periodicity. Gene expression. Gene mapping. Gene Expression Regulation. Gene Expression. Chromosome Mapping.

Summary	Biologists have long be interested in systems that are responsible for the regulation of development and how they evolved. Of great importance in this regard is the discovery of the vertebrate Hox genes, a group of genes responsible for embryonic development. Hybridization analysis of numerous vertebrate and invertebrate species has revealed the presence of Hox genes in each of the organisms studied, indicating that this class of genes is evolutionarily ancient. In mammals Hox genes are located on separate chromosomes in four distinct clusters, in which the clusters are presumed to have been derived from the duplication of a single ancestral cluster. The purpose of this investigation was to determine if Morone saxatilis (striped bass), a nonmammalian vertebrate, has a similar complement and organization of Hox genes to that of the mammals. We obtained the complete DNA sequence from a bacteriophage lambda-EMBL 3 derived clone prepared from Morone saxatilis genomic DNA. Clone 7H was found to contain two Hox genes, located approximately 7.5kb apart. These two genes were found to be homologous to the known mammalian Hox genes HoxA5 and HoxA7, and were located on the clone in the same order relative to each other as HoxA5 and HoxA7 are in the mammals. Despite the linkage of Morone saxatilis HoxA5 and HoxA7 genes, I was unable to identify a gene corresponding to HoxA6 in the intergenic region between HoxAS and HoxA7. The apparent absence of a HoxA6 gene in the region between HoxA5 and HoxA7 in Morone saxatilis, a representative of the perciform fish, demonstrates that Hox gene evolution in this teleost differs from that in other characterized vertebrates.
General note	Submitted to the faculty of the Department of Biology.
General note	Advisor: Edmund J. Stellwag
Dissertation note	M.S. East Carolina University 1997
Bibliography note	Includes bibliographical references (leaves 34-40).
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

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DNA sequence analysis of two Hox genes in the teleost Morone saxatilis : implications for the evolution of the Hox gene family in vertebrates / by Thomas A. Giesler.

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