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035 a| (OCoLC)1381679556;

090 a| RC548;

049 a| EREE;

100 1 a| Antar, Marwa,e| author.?| UNAUTHORIZED;

245 10 a| Graph theoretic analysis of the human brain's functional connectivity alteration due to sleep restriction /c| by Marwa Antar.;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2023.;

300 a| 1 online resource (100 pages) :b| illustrations (some color);

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text fileb| PDFc| 1.832 MB2| rda;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| M.S.c| East Carolina Universityd| 2023.;

500 a| Presented to the Faculty of the Department of Engineering;

500 a| Advisor: Sunghan Kim;

500 a| Title from PDF t.p. (viewed August 1, 2024).;

520 3 a| Sleep plays a vital role in learning and memory consolidation. Several studies used brain models of sleep deprivation (SD) and insomnia to study the association between sleep deficiency and cognitive decline conditions. SD was found to cause similar, albeit subtle, cognitive decline symptoms displayed by dementia patients affecting attentional functions, decision making, working and long-term memory. This study examines the effect of sleep restriction (SR) on brain networks and utilizes Functional Connectivity (FC) analysis to identify patterns of information processing between different brain regions. It particularly applies weighted phase-lag index (wPLI) to quantify brain signals synchronization levels during a visual oddball paradigm task that evokes event-related potentials (ERPs) associated with face recognition. This study also examines the viability of graph theoretic analysis (GTA), which provides a holistic view on the brain network topology. GTA quantifies the brain connectivity features to assess the global efficiency and local efficiency of information processing, pre- and post- SR intervention. Significant alterations were found in all graph indices mainly in [alpha]-, [mu]- and [beta]- frequency bands due to induced mental fatigue. The obtained results reveal significantly lower local connections (p [less-than] 0.05) and lower global efficiency (p [less-than] 0.001), particularly in the [alpha]- band as a result of mental fatigue, reflecting the impact of sleep loss on attention and memory processing.;

504 a| Includes bibliographical references.;

650 0 a| Sleep deprivation.=| ^A119582;

650 0 a| Graph theory.=| ^A31040;

650 0 a| Holistic medicine.=| ^A9899;

653 a| Functional connectivity;

653 a| network analysis;

653 a| sleep restriction;

653 a| cognitive decline;

653 a| brain network;

653 a| event-related potential;

653 a| electroencephalogram;

700 1 a| Kim, Sunghan,d| 1975-e| degree supervisor.1| https://id.oclc.org/worldcat/entity/E39PCjwGh6Dqv9BjgW6VV9mWpd=| ^A1434862;

710 2 a| East Carolina University.b| Department of Engineering.=| ^A1231592;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/12852;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 6143737;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 6143737-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 6/9/2023x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 6143737-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 6/9/2023x| ETDz| HERESOURCE;

Graph theoretic analysis of the human brain's functional connectivity alteration due to sleep restriction / by Marwa Antar.

Author/creator	Antar, Marwa author.
Other author	Kim, Sunghan, 1975- degree supervisor.
Other author	East Carolina University. Department of Engineering.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2023.
Description	1 online resource (100 pages) : illustrations (some color)
Supplemental Content	Access via ScholarShip
Subjects	Sleep deprivation. Graph theory. Holistic medicine.

Summary	Sleep plays a vital role in learning and memory consolidation. Several studies used brain models of sleep deprivation (SD) and insomnia to study the association between sleep deficiency and cognitive decline conditions. SD was found to cause similar, albeit subtle, cognitive decline symptoms displayed by dementia patients affecting attentional functions, decision making, working and long-term memory. This study examines the effect of sleep restriction (SR) on brain networks and utilizes Functional Connectivity (FC) analysis to identify patterns of information processing between different brain regions. It particularly applies weighted phase-lag index (wPLI) to quantify brain signals synchronization levels during a visual oddball paradigm task that evokes event-related potentials (ERPs) associated with face recognition. This study also examines the viability of graph theoretic analysis (GTA), which provides a holistic view on the brain network topology. GTA quantifies the brain connectivity features to assess the global efficiency and local efficiency of information processing, pre- and post- SR intervention. Significant alterations were found in all graph indices mainly in [alpha]-, [mu]- and [beta]- frequency bands due to induced mental fatigue. The obtained results reveal significantly lower local connections (p [less-than] 0.05) and lower global efficiency (p [less-than] 0.001), particularly in the [alpha]- band as a result of mental fatigue, reflecting the impact of sleep loss on attention and memory processing.
General note	Presented to the Faculty of the Department of Engineering
General note	Advisor: Sunghan Kim
General note	Title from PDF t.p. (viewed August 1, 2024).
Dissertation note	M.S. East Carolina University 2023.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

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Graph theoretic analysis of the human brain's functional connectivity alteration due to sleep restriction / by Marwa Antar.

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