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100 1 a| Morillon, Antonin.?| UNAUTHORIZED;

245 10 a| Long non-coding RNAh| [electronic resource] :b| the dark side of the genome /c| Antonin Morillon.;

300 a| xviii, 169 pages :b| Illustrations ;c| 24 cm.;

490 1 a| RNA set;

504 a| Includes bibliographical references (pages 105-149) and index.;

505 0 a| Foreword -- Preface -- Non-coding RNA, its history and discovery timeline -- Definition and families of long non-coding RNA -- Biological functions of long non-coding RNA -- Non-coding RNA in development -- Long non-coding RNA and cancer -- Concluding perspectives.;

506 a| Available only to authorized users.;

520 a| "The dark side of the genome represents vast domains of the genome that are not encoding for proteins--the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function. Here, we review this expanding field of research and present the broad functional diversities of those molecules and their putative fundamental and therapeutic roles. We develop the recent history of non-coding RNA, their very much debated classification and how they raise a formidable interest for developmental and tumorigenesis biology. Using classical examples and an extensive bibliography, we illustrate the most studied and attractive examples of these long non-coding RNA, how they interface with epigenetics, genome integrity and expression and what are the current models of their regulatory mechanisms."--Page 4 of cover.;

538 a| Mode of access: World Wide Web;

650 0 a| Non-coding RNA.=| ^A1037000;

650 12 a| RNA, Long Noncoding.=| ^A1349895;

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830 0 a| RNA set.?| UNAUTHORIZED;

856 40 z| Full text available from eBook - Biomedical Science and Medicine 2018u| https://go.openathens.net/redirector/ecu.edu?url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Fbook%2F9781785482656;

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Long non-coding RNA the dark side of the genome / Antonin Morillon.

Author/creator	Morillon, Antonin
Format	Electronic
Publication Info	London, UK : ISTE Press Ltd ; Kidlington, Oxford, UK : Elsevier Ltd, 2018.
Description	xviii, 169 pages : Illustrations ; 24 cm.
Supplemental Content	Full text available from eBook - Biomedical Science and Medicine 2018
Subjects	Non-coding RNA. RNA, Long Noncoding.

Series	RNA set RNA set. UNAUTHORIZED
Contents	Foreword -- Preface -- Non-coding RNA, its history and discovery timeline -- Definition and families of long non-coding RNA -- Biological functions of long non-coding RNA -- Non-coding RNA in development -- Long non-coding RNA and cancer -- Concluding perspectives.
Abstract	"The dark side of the genome represents vast domains of the genome that are not encoding for proteins--the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function. Here, we review this expanding field of research and present the broad functional diversities of those molecules and their putative fundamental and therapeutic roles. We develop the recent history of non-coding RNA, their very much debated classification and how they raise a formidable interest for developmental and tumorigenesis biology. Using classical examples and an extensive bibliography, we illustrate the most studied and attractive examples of these long non-coding RNA, how they interface with epigenetics, genome integrity and expression and what are the current models of their regulatory mechanisms."--Page 4 of cover.
Bibliography note	Includes bibliographical references (pages 105-149) and index.
Access restriction	Available only to authorized users.
Technical details	Mode of access: World Wide Web
Genre/form	Electronic books.
LCCN	2018300966
ISBN	9781785482656 (hardback)
ISBN	1785482653 (hardback)

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Long non-coding RNA the dark side of the genome / Antonin Morillon.

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