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035 a| (Sirsi) o1332541656;

035 a| (OCoLC)1332541656;

049 a| EREE;

090 a| QH603.C43;

100 1 a| Sanders, Sydney,e| author.=| ^A1460054;

245 14 a| The role of drosophila nuclear receptor ftz-f1 in somatic cells is neccessary for germline stem cell maintenance /c| by Sydney Sanders.;

246 3 a| Role of drosophila nuclear receptor ftz-f1 in somatic cells is necessary for germline stem cell maintenance;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2022.;

300 a| 1 online resource (66 pages) :b| color illustrations;

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text file;

347 b| PDF;

347 c| 14.28 MB;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| M.S.c| East Carolina Universityd| 2022;

500 a| Presented to the Faculty of the Department of BIOLOGY;

500 a| Advisor: Elizabeth T. Ables;

500 a| Title from PDF t.p. (viewed September 19, 2023).;

520 3 a| The production of gametes is a controlled synergistic relationship between germ cells and somatic cells. In Drosophila oogenesis, the NR5A subfamily nuclear receptor ftz-f1 is expressed in the germline stem cells, germ cysts, somatic escort cells, and follicle cells. Ftz-f1 has been identified for its roles in oocyte production to promote egg chamber survival, germline stem cell maintenance, and ecdysteroid signaling. This paper identifies ftz-f1 in the escort cells as an important, but not a sole contributor, to germ cell encapsulation and oocyte specification. We also demonstrate that depletion of ftz-f1 in the escort cells and neurons results in a loss of germline stem cells from the niche that can be rescued by external supplement of ecdysone. Interestingly, we find that ftz-f1 is likely necessary in neural tissue only for germline stem cell maintenance. This study highlights the importance of somatic and germline cell communication and provides novel potential insight into long range signaling between the nervous system and reproductive systems.;

504 a| Includes bibliographical references.;

650 0 a| Nuclear receptors (Biochemistry)=| ^A828141;

650 0 a| Drosophila.=| ^A54199;

650 0 a| Stem cellsx| Research.=| ^A707564;

653 a| Germ cell;

653 a| escort cell;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

700 1 a| Ables, Elizabeth Tweedie,e| degree supervisor.=| ^A1314283;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 40 u| http://hdl.handle.net/10342/10639z| Access via ScholarShip;

949 o| wjh;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 5831705;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5831705-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 6/23/2022x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5831705-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 6/23/2022x| ETDz| HERESOURCE;

The role of drosophila nuclear receptor ftz-f1 in somatic cells is neccessary for germline stem cell maintenance / by Sydney Sanders.

Author/creator	Sanders, Sydney author.
Other author	Ables, Elizabeth Tweedie, degree supervisor.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2022.
Description	1 online resource (66 pages) : color illustrations
Supplemental Content	Access via ScholarShip
Subjects	Nuclear receptors (Biochemistry) Drosophila. Stem cells--Research.

Variant title	Role of drosophila nuclear receptor ftz-f1 in somatic cells is necessary for germline stem cell maintenance
Summary	The production of gametes is a controlled synergistic relationship between germ cells and somatic cells. In Drosophila oogenesis, the NR5A subfamily nuclear receptor ftz-f1 is expressed in the germline stem cells, germ cysts, somatic escort cells, and follicle cells. Ftz-f1 has been identified for its roles in oocyte production to promote egg chamber survival, germline stem cell maintenance, and ecdysteroid signaling. This paper identifies ftz-f1 in the escort cells as an important, but not a sole contributor, to germ cell encapsulation and oocyte specification. We also demonstrate that depletion of ftz-f1 in the escort cells and neurons results in a loss of germline stem cells from the niche that can be rescued by external supplement of ecdysone. Interestingly, we find that ftz-f1 is likely necessary in neural tissue only for germline stem cell maintenance. This study highlights the importance of somatic and germline cell communication and provides novel potential insight into long range signaling between the nervous system and reproductive systems.
General note	Presented to the Faculty of the Department of BIOLOGY
General note	Advisor: Elizabeth T. Ables
General note	Title from PDF t.p. (viewed September 19, 2023).
Dissertation note	M.S. East Carolina University 2022
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.
Genre/form	Academic theses.
Genre/form	Academic theses.

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The role of drosophila nuclear receptor ftz-f1 in somatic cells is neccessary for germline stem cell maintenance / by Sydney Sanders.

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