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001 on1268150289;

003 OCoLC;

005 20221026165753.0;

006 m o d ;

007 cr unu||||||||;

008 210914s2021 ncua obm 000 0 eng d;

035 a| (Sirsi) o1268150289;

035 a| (OCoLC)1268150289;

049 a| EREE;

050 0 a| QH470.D7;

100 1 a| Whitehead, Kaitlin M.,e| author.?| UNAUTHORIZED;

245 10 a| Somatic steroid hormone signaling promotes early oocyte polarization in Drosophila /c| by Kaitlin M. Whitehead.;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2021.;

300 a| 1 online resource (56 pages) :b| color illustrations;

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text file;

347 b| PDF;

347 c| 1.700 MB;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| M.S.c| East Carolina Universityd| 2021;

500 a| Presented to the faculty of the Department of Biology;

500 a| Advisor: Elizabeth T. Ables;

500 a| Title from PDF t.p. (viewed September 7, 2022).;

520 3 a| In the ovary, oogenesis depends on intercellular communication between somatic and germ cell populations for proper oocyte production. Steroid hormone signaling, well-described for its diverse roles throughout oogenesis, contributes to soma-germline communication using cholesterol-derived steroids as ligands to activate or repress transcription in target cells containing the appropriate receptors. To date, research shows defects in cysts development, germline stem cell (GSC) maintenance and somatic escort cell projections when somatic to germline communication is disrupted, yet none display a direct impact on oocyte production. Our findings suggests that the steroid hormone receptor, Ecdysone Receptor (EcR), is required in the escort cells for timely cyst maturation and oocyte polarization and provides insight into the molecular mechanisms responsible for this process.;

504 a| Includes bibliographical references.;

650 0 a| Drosophilax| Genetics.=| ^A188960;

650 0 a| Ecdysteroids.=| ^A1448401;

650 0 a| Oogenesis.=| ^A241829;

653 a| Ecdysone Receptor;

653 a| cellular signaling;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

655 2 a| Academic Dissertation.0| (DNLM)D019478?| UNAUTHORIZED;

700 1 a| Ables, Elizabeth Tweedie,e| degree supervisor.=| ^A1314283;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 40 u| http://hdl.handle.net/10342/9422z| Access via ScholarShip;

949 o| wjh;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 5668832;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5668832-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 9/14/2021x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5668832-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 9/14/2021x| ETDz| HERESOURCE;

Somatic steroid hormone signaling promotes early oocyte polarization in Drosophila / by Kaitlin M. Whitehead.

Author/creator	Whitehead, Kaitlin M. author.
Other author	Ables, Elizabeth Tweedie, degree supervisor.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2021.
Description	1 online resource (56 pages) : color illustrations
Supplemental Content	Access via ScholarShip
Subjects	Drosophila--Genetics. Ecdysteroids. Oogenesis.

Summary	In the ovary, oogenesis depends on intercellular communication between somatic and germ cell populations for proper oocyte production. Steroid hormone signaling, well-described for its diverse roles throughout oogenesis, contributes to soma-germline communication using cholesterol-derived steroids as ligands to activate or repress transcription in target cells containing the appropriate receptors. To date, research shows defects in cysts development, germline stem cell (GSC) maintenance and somatic escort cell projections when somatic to germline communication is disrupted, yet none display a direct impact on oocyte production. Our findings suggests that the steroid hormone receptor, Ecdysone Receptor (EcR), is required in the escort cells for timely cyst maturation and oocyte polarization and provides insight into the molecular mechanisms responsible for this process.
General note	Presented to the faculty of the Department of Biology
General note	Advisor: Elizabeth T. Ables
General note	Title from PDF t.p. (viewed September 7, 2022).
Dissertation note	M.S. East Carolina University 2021
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

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Somatic steroid hormone signaling promotes early oocyte polarization in Drosophila / by Kaitlin M. Whitehead.

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