Lahita's systemic lupus erythematosus / edited by Robert G. Lahita.

Other author Lahita, Robert G. (Robert George), 1945- editor.
Format Electronic
EditionSixth edition.
PublicationAmsterdam : Academic Press, 2021.
Description1 online resource : illustrations (black and white, and colour)
Supplemental Content Direct link to eBook
Subjects
Lupus Erythematosus, Systemic.

Portion of title Systemic lupus erythematosus
Contents Front Cover -- LAHITA'S SYSTEMIC LUPUS ERYTHEMATOSUS -- LAHITA'S SYSTEMIC LUPUS ERYTHEMATOSUS -- Copyright -- Dedication -- Contents -- Contributors -- Foreword -- Foreword from the First Edition -- Preface to Edition 6, Systemic Lupus Erythematosus -- Acknowledgment -- History of lupus erythematosus -- References -- I -- Basis of the disease -- A Genetics and epigenetics -- 1 -- Major histocompatibility complex and SLE -- The MHC region -- Overview -- Subregions of the MHC -- Evolution and gene clustering in the human MHC -- HLA polymorphism -- Extended linkage disequilibrium at the MHC
Contents Conserved extended haplotypes/ancestral haplotypes -- The sequence of the MHC -- Nomenclature of HLA and non-HLA alleles -- HLA class I molecules -- HLA class II molecules -- HLA-DRB gene haplotypes -- Genome-wide association studies and the MHC -- HLA typing by imputation -- MHC class III and the RCCX module -- The MHC region and SLE (HLA) -- The MHC region and SLE (complement) -- SNP-based MHC analyses in SLE -- Targeted SNP-based analysis -- GWAS and the MHC -- ImmunoChip and the MHC -- Combining SNPs with structural variation at the RCCX module -- Additional MHC associations with SLE
Contents The future...defining mechanisms -- References -- 2 -- Lupus susceptibility genes -- Introduction -- Identifying SLE susceptibility genes -- Pleotropic effects of SLE risk loci -- SLE risk loci impact pathways involved in key immune processes -- Autophagy, apoptosis, and exposure to self-antigens -- Interferon signaling -- The role of chromosome X in SLE -- Clinical translation of genetic findings -- Concluding remarks -- References -- 3 -- Epigenetics in systemic lupus erythematosus and the integration of molecular pathways -- Introduction -- What is epigenetics? -- DNA methylation in SLE
Contents Global loss of DNA methylation in lupus patients -- Hypomethylation in autoimmune-related genes: classical examples -- Defects in X-chromosome inactivation in SLE -- Increased retrotransposon genomic activity in SLE -- Global DNA methylation and CpG immunity -- Epigenome-wide association studies for SLE -- Methodological and statistical considerations of EWAS -- Choice of tissue -- Study design and interpretability of results -- Genome-wide DNA methylation association studies -- Pervasive hypomethylation of interferon-regulated genes -- Beyond the interferon signature
Contents Cell-specific DNA methylation signatures -- Activity-dependent DNA methylation signatures -- DNA methylation in relation to clinical phenotypes -- DNA hydroxymethylation landscape in SLE -- Histone modification landscapes in SLE -- MicroRNA changes in SLE -- Epigenetics as an intermediary of genetic and environmental risk -- Lupus stratification based on molecular profiles -- A bridge between clinical and molecular heterogeneity -- Molecular stratification "a new hope" -- Diagnostic and therapeutic implications of epigenetics -- Conclusions and future perspectives -- References
Genre/formElectronic books.
ISBN9780323914888 (e-book)
ISBN0323914888 (e-book)

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