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245 00 a| Cyclic-nucleotide phosphodiesterases in the central nervous systemh| [electronic resource] :b| from biology to drug discovery /c| edited by Nicholas J. Brandon, AstraZeneca Neuroscience, Cambridge, Massachusetts, USA, Anthony R. West, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois.;

260 a| Hoboken, New Jersey :b| John Wiley & Sons, Inc.,c| [2014];

300 a| xi, 386 pages :b| illustrations (some color) ;c| 25 cm.;

504 a| Includes bibliographical references.;

505 0 a| Phosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P. P. Bollen, Kris Rutten, Olga A. H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin.;

506 a| Available only to authorized users.;

538 a| Mode of access: World Wide Web;

650 12 a| 3',5'-Cyclic-AMP Phosphodiesterasesx| metabolism.?| UNAUTHORIZED;

650 12 a| 3',5'-Cyclic-AMP Phosphodiesterasesx| therapeutic use.?| UNAUTHORIZED;

650 22 a| Central Nervous Systemx| physiology.=| ^A921305;

650 22 a| Central Nervous System Diseasesx| drug therapy.=| ^A920539;

650 22 a| Drug Discovery.=| ^A1013013;

655 0 a| Electronic books.=| ^A491897;

700 1 a| Brandon, Nicholas J.?| UNAUTHORIZED;

700 1 a| West, Anthony R.,d| 1970-?| UNAUTHORIZED;

856 40 z| Full text available from Ebook Central - Academic Completeu| https://ebookcentral.proquest.com/lib/eastcarolina/detail.action?docID=1650866;

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Cyclic-nucleotide phosphodiesterases in the central nervous system from biology to drug discovery / edited by Nicholas J. Brandon, AstraZeneca Neuroscience, Cambridge, Massachusetts, USA, Anthony R. West, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois.

Other author	Brandon, Nicholas J.
Other author	West, Anthony R., 1970-
Format	Electronic
Publication Info	Hoboken, New Jersey : John Wiley & Sons, Inc., [2014]
Description	xi, 386 pages : illustrations (some color) ; 25 cm.
Supplemental Content	Full text available from Ebook Central - Academic Complete
Subjects	3',5'-Cyclic-AMP Phosphodiesterases--metabolism. 3',5'-Cyclic-AMP Phosphodiesterases--therapeutic use. Central Nervous System--physiology. Central Nervous System Diseases--drug therapy. Drug Discovery.

Contents	Phosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P. P. Bollen, Kris Rutten, Olga A. H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin.
Bibliography note	Includes bibliographical references.
Access restriction	Available only to authorized users.
Technical details	Mode of access: World Wide Web
Genre/form	Electronic books.
LCCN	2013042742
ISBN	9780470566688 (cloth)
ISBN	047056668X (cloth)

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Cyclic-nucleotide phosphodiesterases in the central nervous system from biology to drug discovery / edited by Nicholas J. Brandon, AstraZeneca Neuroscience, Cambridge, Massachusetts, USA, Anthony R. West, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois.

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