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100 1 a| Pearce, Daniel,e| author.=| ^A1420118;

245 10 a| Fluid-structure interaction modeling of pulmonary artery blood flow in end-stage renal disease patients /c| by Daniel Pearce.;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2020.;

300 a| 1 online resource (147 pages) :b| illustrations (chiefly color);

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text file;

347 b| PDF;

347 c| 3.857 MB;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| Biomedical Engineeringc| East Carolina Universityd| 2020;

500 a| Presented to the Faculty of the Department of Engineering;

500 a| Advisor: Stephanie George;

500 a| Title from PDF t.p. (viewed May 10, 2021).;

520 3 a| If unaddressed, end-stage renal disease (ESRD) can result in impaired renal function, development of cardiovascular diseases, and death. Although effective, dialysis conducted via arteriovenous fistulas (AVF) has been linked to the development of pulmonary hypertension (PH). The objective of this work was to use magnetic resonance imaging (MRI) and computational fluid dynamics (CFD) to model pulmonary artery (PA) blood flow and PA fluid-structure interactions so properties of these models could be related to clinical parameters relevant to PH and ESRD. Due to the global pandemic, one (n =1) adult ESRD patient underwent cardiac MRI for PA reconstruction. Short-axis cine scans and phase-contrast scans were used respectively to recreate the patient's PA geometry in Mimics 20.0, an imaging segmentation software, and derive a patient-specific velocity waveform of blood flow at the PA inlet. Computational fluid dynamics (CFD) and finite element models of vessel deformation were created in ANSYS Workbench 19.1. Steady-state models (CFD, linear elastic fluid-structure interaction (FSI), and hyperelastic FSI) were run using a constant inlet velocity and, where applicable, mechanical properties for vessel walls taken from literature. Transient models (CFD and linear elastic FSI) were also created to simulate pulsatile blood flow and, where applicable, the interaction with the artery wall. Moderate differences were observed among the various steady-state models, whereas only minimal differences were found between transient models. These differences may be due to limited mesh resolution, which was later identified in a mesh sensitivity analysis. Although only minor differences were found between fluid results for the transient CFD and FSI model, the computational cost of the FSI model was much greater. FSI models of PA hemodynamics may not offer different results for hemodynamic properties, but they may be used in future studies when arterial remodeling and cellular stress and strain distributions are of interest. This study offered insight into computational modeling of PA blood flow and may be used as reference for future studies seeking to apply this methodology to a larger patient population. Eventually, this type of modeling may be used to identify metrics of interest that physicians can use to more closely monitor AVF development during hemodialysis.;

504 a| Includes bibliographical references.;

650 0 a| Kidneysx| Diseasesx| Prevention.=| ^A614;

650 0 a| Magnetic resonance imaging.=| ^A149674;

650 0 a| Computational fluid dynamics.=| ^A367780;

655 7 a| Academic theses.2| lcgft;

700 1 a| George, Stephanie,e| degree supervisor.=| ^A1348276;

710 2 a| East Carolina University.b| Department of Engineering.=| ^A1231592;

856 40 u| http://hdl.handle.net/10342/8746z| Access via ScholarShip;

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999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5524888-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 10/26/2020x| ETDz| HERESOURCE;

Fluid-structure interaction modeling of pulmonary artery blood flow in end-stage renal disease patients / by Daniel Pearce.

Author/creator	Pearce, Daniel author.
Other author	George, Stephanie, degree supervisor.
Other author	East Carolina University. Department of Engineering.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2020.
Description	1 online resource (147 pages) : illustrations (chiefly color)
Supplemental Content	Access via ScholarShip
Subjects	Kidneys--Diseases. --Prevention. Magnetic resonance imaging. Computational fluid dynamics.

Summary	If unaddressed, end-stage renal disease (ESRD) can result in impaired renal function, development of cardiovascular diseases, and death. Although effective, dialysis conducted via arteriovenous fistulas (AVF) has been linked to the development of pulmonary hypertension (PH). The objective of this work was to use magnetic resonance imaging (MRI) and computational fluid dynamics (CFD) to model pulmonary artery (PA) blood flow and PA fluid-structure interactions so properties of these models could be related to clinical parameters relevant to PH and ESRD. Due to the global pandemic, one (n =1) adult ESRD patient underwent cardiac MRI for PA reconstruction. Short-axis cine scans and phase-contrast scans were used respectively to recreate the patient's PA geometry in Mimics 20.0, an imaging segmentation software, and derive a patient-specific velocity waveform of blood flow at the PA inlet. Computational fluid dynamics (CFD) and finite element models of vessel deformation were created in ANSYS Workbench 19.1. Steady-state models (CFD, linear elastic fluid-structure interaction (FSI), and hyperelastic FSI) were run using a constant inlet velocity and, where applicable, mechanical properties for vessel walls taken from literature. Transient models (CFD and linear elastic FSI) were also created to simulate pulsatile blood flow and, where applicable, the interaction with the artery wall. Moderate differences were observed among the various steady-state models, whereas only minimal differences were found between transient models. These differences may be due to limited mesh resolution, which was later identified in a mesh sensitivity analysis. Although only minor differences were found between fluid results for the transient CFD and FSI model, the computational cost of the FSI model was much greater. FSI models of PA hemodynamics may not offer different results for hemodynamic properties, but they may be used in future studies when arterial remodeling and cellular stress and strain distributions are of interest. This study offered insight into computational modeling of PA blood flow and may be used as reference for future studies seeking to apply this methodology to a larger patient population. Eventually, this type of modeling may be used to identify metrics of interest that physicians can use to more closely monitor AVF development during hemodialysis.
General note	Presented to the Faculty of the Department of Engineering
General note	Advisor: Stephanie George
General note	Title from PDF t.p. (viewed May 10, 2021).
Dissertation note	Biomedical Engineering East Carolina University 2020
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.
Genre/form	Academic theses.

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Fluid-structure interaction modeling of pulmonary artery blood flow in end-stage renal disease patients / by Daniel Pearce.

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