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020 a| 0128016639;

020 a| 9780128016633;

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090 a| RA1224.3b| .T49 2016;

245 00 a| Thresholds of genotoxic carcinogensh| [electronic resource] :b| from mechanisms to regulation /c| edited by Takehiko Nohmi, Shoji Fukushima.;

260 a| Amsterdam :b| Elsevier, Academic Press,c| [2016];

300 a| xiv, 210 pages :b| illustrations ;c| 25 cm;

504 a| Includes bibliographical references and index.;

505 0 a| Qualitative and quantitative assessments on low-dose carcinogenicity of genotoxic hepatocarcinogens : dose-response for key events in rat hepatocarcinogenesis -- Thresholds for hepatocarcinogenicity of DNA-reactive compounds -- Interaction of low-dose radiation and chemicals in cancer risk -- Possible mechanisms underlying genotoxic thresholds : DNA repair and translesion DNA synthesis -- DNA repair and its influence on points of departure for alkylating agent genotoxicity -- The role of endogenous versus exogenous DNA damage in risk assessment -- Thresholds of toxicological concern for genotoxic impurities in pharmaceuticals -- Practical thresholds in the derivation of occupational exposure limits (OELs) for carcinogens -- Experimental design and statistical analysis of threshold studies -- Nrf2 as a possible determinant of the threshold for carcinogenesis -- Assessment of nongenotoxic mechanisms in carcinogenicity test of chemicals; Quinone, quinone imine, and quinone methide as examples -- Mode of action and assessment of human relevance for chemical-induced animal tumors.;

506 a| Available only to authorized users.;

538 a| Mode of access: World Wide Web;

650 12 a| Carcinogenesis0| https://id.nlm.nih.gov/mesh/D063646=| ^A1195297;

650 22 a| Carcinogensx| toxicity0| https://id.nlm.nih.gov/mesh/D002273Q000633=| ^A924450;

650 22 a| DNA Damage0| https://id.nlm.nih.gov/mesh/D004249=| ^A926668;

650 22 a| Dose-Response Relationship, Drug0| https://id.nlm.nih.gov/mesh/D004305=| ^A920467;

650 22 a| Mutagenicity Tests0| https://id.nlm.nih.gov/mesh/D009152=| ^A965888;

655 0 a| Electronic books.=| ^A491897;

700 1 a| Nohmi, Takehiko.=| ^A1301457;

700 1 a| Fukushima, Shōji.=| ^A1301519;

856 40 z| Full text available from eBooks on EBSCOhostu| https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=1144275&scope=site&custid=s5822723&authtype=ip,shib;

856 40 z| Full text available from eBook - Pharmacology, Toxicology and Pharmaceutical Science 2016 [EBCPTPS16]u| https://go.openathens.net/redirector/ecu.edu?url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Fbook%2F9780128016633;

947 a| (OCoLC)968132514;

949 a| CLICK ON WEB ADDRESSw| ASISh| JOYNER188;

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999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5331637-2001l| HSLELECm| HSLr| Ys| Yt| HEBKu| 6/14/2020x| EBOOKz| HERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5331637-3001l| MNETm| JMUSICr| Ys| Yt| MNESSBKu| 6/14/2020x| EBOOKz| JERESOURCE;

Thresholds of genotoxic carcinogens from mechanisms to regulation / edited by Takehiko Nohmi, Shoji Fukushima.

Other author	Nohmi, Takehiko.
Other author	Fukushima, Shōji.
Format	Electronic
Publication Info	Amsterdam : Elsevier, Academic Press, [2016]
Description	xiv, 210 pages : illustrations ; 25 cm
Supplemental Content	Full text available from eBooks on EBSCOhost
Supplemental Content	Full text available from eBook - Pharmacology, Toxicology and Pharmaceutical Science 2016 [EBCPTPS16]
Subjects	Carcinogenesis Carcinogens--toxicity. DNA Damage Dose-Response Relationship, Drug Mutagenicity Tests

Contents	Qualitative and quantitative assessments on low-dose carcinogenicity of genotoxic hepatocarcinogens : dose-response for key events in rat hepatocarcinogenesis -- Thresholds for hepatocarcinogenicity of DNA-reactive compounds -- Interaction of low-dose radiation and chemicals in cancer risk -- Possible mechanisms underlying genotoxic thresholds : DNA repair and translesion DNA synthesis -- DNA repair and its influence on points of departure for alkylating agent genotoxicity -- The role of endogenous versus exogenous DNA damage in risk assessment -- Thresholds of toxicological concern for genotoxic impurities in pharmaceuticals -- Practical thresholds in the derivation of occupational exposure limits (OELs) for carcinogens -- Experimental design and statistical analysis of threshold studies -- Nrf2 as a possible determinant of the threshold for carcinogenesis -- Assessment of nongenotoxic mechanisms in carcinogenicity test of chemicals; Quinone, quinone imine, and quinone methide as examples -- Mode of action and assessment of human relevance for chemical-induced animal tumors.
Bibliography note	Includes bibliographical references and index.
Access restriction	Available only to authorized users.
Technical details	Mode of access: World Wide Web
Genre/form	Electronic books.
ISBN	0128016639
ISBN	9780128016633

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	Electronic Resources	Online Content Full text available from eBooks on EBSCOhost Full text available from eBook - Pharmacology, Toxicology and Pharmaceutical Science 2016 [EBCPTPS16]	✔ Available

Thresholds of genotoxic carcinogens from mechanisms to regulation / edited by Takehiko Nohmi, Shoji Fukushima.

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