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010 a| 2016937843;

020 a| 9780128030721;

020 a| 0128030720;

035 a| (WaSeSS)ssj0001730396;

042 a| lccopycat;

049 a| EREEa| NEHH;

050 00 a| RA1231.M52b| A18 2016;

082 04 a| 615.9/2532| 23;

100 1 a| Aaseth, Jan.?| UNAUTHORIZED;

245 10 a| Chelation therapy in the treatment of metal intoxicationh| [electronic resource] /c| Jan Aaseth, Department of Public Health, Hedmark University College, Elverum, Department of Internal Medicine, Innlandet Hospital, Kongsvinger, Hedmark, Norway, Guido Criponi, Department of Chemical and Geological Sciences, University of Cagliari, Cagliari, Italy, Ole Andersen, Department of Science and Environment, Roskilde University, Roskilde, Denmark.;

260 a| London, UK ;a| San Diego, CA, USA :b| Academic Press is an imprint of Elsevier,;

300 a| xvi, 371 pages :b| illustrations ;c| 24 cm;

500 a| Includes bibliographical references and index.;

505 0 a| Cover; Title Page; Copyright Page; Contents; Contributors; Preface; List of Abbreviations; Chapter 1 -- General Chemistry of Metal Toxicity and Basis for Metal Complexation; 1.1 -- General chemistry of metals; 1.2 -- Essential and nonessential elements; 1.3 -- Effects of toxic exposure of an essential or nonessential metal; 1.3.1 -- Basic Concepts in Chemical Toxicity Testing; 1.3.2 -- Exposure Patterns and Mechanisms of Metal Toxicity; 1.3.3 -- Gastrointestinal Effects of Metal Exposure; 1.3.4 -- Respiratory Effects of Metal Exposure; 1.3.5 -- Hepatic and Renal Effects.;

505 8 a| 1.3.6 -- Effects on the Nervous System1.3.7 -- Hematological Effects; 1.3.8 -- Cardiovascular Effects; 1.3.9 -- Metal Allergies; 1.3.10 -- Carcinogenic Effects; 1.4 -- Basis for metal complex formation with endogenous and exogenous ligands; 1.5 -- Endogenous complexing and detoxification compounds; 1.5.1 -- Albumin; 1.5.2 -- Transferrin and Ferritin; 1.5.3 -- Glutathione; 1.5.4 -- Metallothionein; 1.5.5 -- Selenoproteins; 1.6 -- Conclusions; References; Chapter 2 -- Chelating Agents as Therapeutic Compounds-Basic Principles; 2.1 -- Chemical and biological principles for in vivo chelation; 2.1.1 -- Stability.;

505 8 a| 2.1.2 -- Selectivity2.1.3 -- Kinetic Aspects of Chelation; 2.1.4 -- Absorption and Bioavailability of Chelating Agents; 2.2 -- Chelating agents: chemistry, kinetics, and toxicology; 2.2.1 -- BAL, DMPS, DMSA; 2.2.2 -- D-penicillamine; 2.2.3 -- Triethylenetetramine; 2.2.4 -- Deferoxamine, Deferiprone, and Deferasirox; 2.2.5 -- EDTA and DTPA; 2.2.6 -- Prussian Blue; References; Chapter 3 -- Diagnosis and Evaluation of Metal Poisonings and Chelation Therapy; 3.1 -- Introduction; 3.2 -- History of symptoms and exposure; 3.3 -- Clinical findings; 3.4 -- Genetic disorders with systemic metal accumulation.;

505 8 a| 3.5 -- Toxicological analyses3.6 -- Biochemical measurements; 3.7 -- Physiological, radiological, and ultrasonographic investigations; References; Chapter 4 -- Chelation Treatment During Acute and Chronic Metal Overexposures-Experimental and Clinical Studies; 4.1 -- Introduction; 4.2 -- Aluminum; 4.2.1 -- Selected Representative Animal Studies; 4.2.2 -- Selected Representative Clinical Studies; 4.2.3 -- Conclusions; 4.3 -- Antimony; 4.3.1 -- Animal Experiments; 4.3.2 -- Clinical Cases; 4.3.3 -- Conclusion; 4.4 -- Arsenic; 4.4.1 -- Selected Animal Experiments; 4.4.2 -- Clinical Studies.;

505 8 a| 4.4.3 -- Discussion and Conclusion4.5 -- Beryllium; 4.5.1 -- Experimental Chelation Studies; 4.5.2 -- Clinical Experience; 4.5.3 -- Conclusion; 4.6 -- Bismuth; 4.6.1 -- Animal Chelation Studies; 4.6.2 -- Clinical Chelation Studies; 4.6.3 -- Conclusion; 4.7 -- Cadmium; 4.7.1 -- Animal Chelation Experiments; 4.7.2 -- Clinical Chelation Studies; 4.7.3 -- Conclusion; 4.8 -- Chromium; 4.8.1 -- Animal Experimental Studies; 4.8.2 -- Clinical Cases; 4.8.3 -- Conclusion; 4.9 -- Cobalt; 4.9.1 -- Chelation, Animal Experiments; 4.9.2 -- Chelation, Clinical Studies; 4.9.3 -- Conclusion; 4.10 -- Copper.;

505 8 a| 4.10.1 -- Animal Chelation Studies.;

506 a| Available only to authorized users.;

538 a| Mode of access: World Wide Web;

650 0 a| Chelation therapy.=| ^A390274;

650 7 a| Chelation therapy.2| fast0| (OCoLC)fst00852798;

655 0 a| Electronic books.=| ^A491897;

700 1 a| Criponi, Guido.?| UNAUTHORIZED;

700 1 a| Andersen, Ole.?| UNAUTHORIZED;

856 40 z| Full text available from eBook - Pharmacology, Toxicology and Pharmaceutical Science 2016 [EBCPTPS16]u| https://go.openathens.net/redirector/ecu.edu?url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Fbook%2F9780128030721;

947 a| (OCoLC)ocn938383554;

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949 a| CLICK ON WEB ADDRESSw| ASISh| JMUSIC60;

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998 a| 5241603;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5241603-1001l| JNETm| JOYNERr| Ys| Yt| JNESSBKu| 2/13/2020x| EBOOKz| JERESOURCE;

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999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5241603-3001l| MNETm| JMUSICr| Ys| Yt| MNESSBKu| 2/13/2020x| EBOOKz| JERESOURCE;

Chelation therapy in the treatment of metal intoxication / Jan Aaseth, Department of Public Health, Hedmark University College, Elverum, Department of Internal Medicine, Innlandet Hospital, Kongsvinger, Hedmark, Norway, Guido Criponi, Department of Chemical and Geological Sciences, University of Cagliari, Cagliari, Italy, Ole Andersen, Department of Science and Environment, Roskilde University, Roskilde, Denmark.

Author/creator	Aaseth, Jan
Other author	Criponi, Guido.
Other author	Andersen, Ole.
Format	Electronic
Publication Info	London, UK ; San Diego, CA, USA : Academic Press is an imprint of Elsevier,
Description	xvi, 371 pages : illustrations ; 24 cm
Supplemental Content	Full text available from eBook - Pharmacology, Toxicology and Pharmaceutical Science 2016 [EBCPTPS16]
Subjects	Chelation therapy.

Contents	Cover; Title Page; Copyright Page; Contents; Contributors; Preface; List of Abbreviations; Chapter 1 -- General Chemistry of Metal Toxicity and Basis for Metal Complexation; 1.1 -- General chemistry of metals; 1.2 -- Essential and nonessential elements; 1.3 -- Effects of toxic exposure of an essential or nonessential metal; 1.3.1 -- Basic Concepts in Chemical Toxicity Testing; 1.3.2 -- Exposure Patterns and Mechanisms of Metal Toxicity; 1.3.3 -- Gastrointestinal Effects of Metal Exposure; 1.3.4 -- Respiratory Effects of Metal Exposure; 1.3.5 -- Hepatic and Renal Effects.
Contents	1.3.6 -- Effects on the Nervous System1.3.7 -- Hematological Effects; 1.3.8 -- Cardiovascular Effects; 1.3.9 -- Metal Allergies; 1.3.10 -- Carcinogenic Effects; 1.4 -- Basis for metal complex formation with endogenous and exogenous ligands; 1.5 -- Endogenous complexing and detoxification compounds; 1.5.1 -- Albumin; 1.5.2 -- Transferrin and Ferritin; 1.5.3 -- Glutathione; 1.5.4 -- Metallothionein; 1.5.5 -- Selenoproteins; 1.6 -- Conclusions; References; Chapter 2 -- Chelating Agents as Therapeutic Compounds-Basic Principles; 2.1 -- Chemical and biological principles for in vivo chelation; 2.1.1 -- Stability.
Contents	2.1.2 -- Selectivity2.1.3 -- Kinetic Aspects of Chelation; 2.1.4 -- Absorption and Bioavailability of Chelating Agents; 2.2 -- Chelating agents: chemistry, kinetics, and toxicology; 2.2.1 -- BAL, DMPS, DMSA; 2.2.2 -- D-penicillamine; 2.2.3 -- Triethylenetetramine; 2.2.4 -- Deferoxamine, Deferiprone, and Deferasirox; 2.2.5 -- EDTA and DTPA; 2.2.6 -- Prussian Blue; References; Chapter 3 -- Diagnosis and Evaluation of Metal Poisonings and Chelation Therapy; 3.1 -- Introduction; 3.2 -- History of symptoms and exposure; 3.3 -- Clinical findings; 3.4 -- Genetic disorders with systemic metal accumulation.
Contents	3.5 -- Toxicological analyses3.6 -- Biochemical measurements; 3.7 -- Physiological, radiological, and ultrasonographic investigations; References; Chapter 4 -- Chelation Treatment During Acute and Chronic Metal Overexposures-Experimental and Clinical Studies; 4.1 -- Introduction; 4.2 -- Aluminum; 4.2.1 -- Selected Representative Animal Studies; 4.2.2 -- Selected Representative Clinical Studies; 4.2.3 -- Conclusions; 4.3 -- Antimony; 4.3.1 -- Animal Experiments; 4.3.2 -- Clinical Cases; 4.3.3 -- Conclusion; 4.4 -- Arsenic; 4.4.1 -- Selected Animal Experiments; 4.4.2 -- Clinical Studies.
Contents	4.4.3 -- Discussion and Conclusion4.5 -- Beryllium; 4.5.1 -- Experimental Chelation Studies; 4.5.2 -- Clinical Experience; 4.5.3 -- Conclusion; 4.6 -- Bismuth; 4.6.1 -- Animal Chelation Studies; 4.6.2 -- Clinical Chelation Studies; 4.6.3 -- Conclusion; 4.7 -- Cadmium; 4.7.1 -- Animal Chelation Experiments; 4.7.2 -- Clinical Chelation Studies; 4.7.3 -- Conclusion; 4.8 -- Chromium; 4.8.1 -- Animal Experimental Studies; 4.8.2 -- Clinical Cases; 4.8.3 -- Conclusion; 4.9 -- Cobalt; 4.9.1 -- Chelation, Animal Experiments; 4.9.2 -- Chelation, Clinical Studies; 4.9.3 -- Conclusion; 4.10 -- Copper.
Contents	4.10.1 -- Animal Chelation Studies.
General note	Includes bibliographical references and index.
Access restriction	Available only to authorized users.
Technical details	Mode of access: World Wide Web
Genre/form	Electronic books.
LCCN	2016937843
ISBN	9780128030721
ISBN	0128030720

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