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016 7 a| 1015297092| DNLM;

016 7 a| 0155000192| Uk;

020 a| 9781420073492 (hardcover : alk. paper);

020 a| 1420073494 (hardcover : alk. paper);

035 a| (WaSeSS)ssj0000410739;

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100 1 a| Kisaalita, William Ssempa,d| 1953-?| UNAUTHORIZED;

245 10 a| 3D cell-based biosensors in drug discovery programsh| [electronic resource] :b| microtissue engineering for high throughput screening /c| William S. Kisaalita.;

246 3 a| Three-dimensional cell-based biosensors in drug discovery programs;

260 a| Boca Raton :b| CRC Press,;

300 a| xvii, 386 p. :b| ill. ;c| 25 cm.;

504 a| Includes bibliographical references and indexes.;

505 0 a| Biosensors and bioassays -- Target-driven drug discovery -- Comparative transcriptional profiling and proteomics -- Comparative structure and function -- Chemical microenvironmental factors -- Spatial and temporal microenvironmental factors -- Material physical property and force microenvironmental factors -- Proteomics as a promising tool in the search for 3D biomarkers -- Readout present and near future -- Ready-to-use commercial 3D plates -- Challenges to adopting 3D cultures in HTS programs -- Cases for 3D cultures in drug discovery -- Ideal case study design.;

506 a| Available only to authorized users.;

520 a| "This book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information"--Provided by publisher.;

538 a| Mode of access: World Wide Web;

650 0 a| Pharmaceutical biotechnology.=| ^A492454;

650 0 a| Biosensors.=| ^A149319;

650 0 a| High throughput screening (Drug development)=| ^A1234122;

650 12 a| Biosensing Techniquesx| methods.=| ^A938567;

650 22 a| Cells, Cultured.=| ^A919828;

650 22 a| Drug Discovery.=| ^A1013013;

655 0 a| Electronic books.=| ^A491897;

856 40 z| Full text available from Ebook Central - Academic Completeu| https://ebookcentral.proquest.com/lib/eastcarolina/detail.action?docID=565953;

947 a| (OCoLC)ocn540161450;

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3D cell-based biosensors in drug discovery programs microtissue engineering for high throughput screening / William S. Kisaalita.

Author/creator	Kisaalita, William Ssempa, 1953-
Format	Electronic
Publication Info	Boca Raton : CRC Press,
Description	xvii, 386 p. : ill. ; 25 cm.
Supplemental Content	Full text available from Ebook Central - Academic Complete
Subjects	Pharmaceutical biotechnology. Biosensors. High throughput screening (Drug development) Biosensing Techniques--methods. Cells, Cultured. Drug Discovery.

Variant title	Three-dimensional cell-based biosensors in drug discovery programs
Contents	Biosensors and bioassays -- Target-driven drug discovery -- Comparative transcriptional profiling and proteomics -- Comparative structure and function -- Chemical microenvironmental factors -- Spatial and temporal microenvironmental factors -- Material physical property and force microenvironmental factors -- Proteomics as a promising tool in the search for 3D biomarkers -- Readout present and near future -- Ready-to-use commercial 3D plates -- Challenges to adopting 3D cultures in HTS programs -- Cases for 3D cultures in drug discovery -- Ideal case study design.
Abstract	"This book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information"--Provided by publisher.
Bibliography note	Includes bibliographical references and indexes.
Access restriction	Available only to authorized users.
Technical details	Mode of access: World Wide Web
Genre/form	Electronic books.
LCCN	2010018119
ISBN	9781420073492 (hardcover : alk. paper)
ISBN	1420073494 (hardcover : alk. paper)

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3D cell-based biosensors in drug discovery programs microtissue engineering for high throughput screening / William S. Kisaalita.

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