Tools

LEADER 03652cam a2200625Ii 4500

001 on1113941983;

003 OCoLC;

005 20200422110312.0;

006 m o d ;

007 cr unu||||||||;

008 190827s2019 ncua obm 000 0 eng d;

035 a| (Sirsi) o1113941983;

035 a| (OCoLC)1113941983;

049 a| EREE;

100 1 a| Serra, Nicholas,e| author.?| UNAUTHORIZED;

245 14 a| The mechanistic target of rapamycin (mTOR) and its complex 1 associated protein RPTOR are germ cell-autonomously required for spermatogonial development & chapter IV :b| investigating changes in the testicular transcriptome during the prospermatogonial transition /c| by Nicholas Serra.;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2019.;

300 a| 211 pages :b| illustrations (chiefly color).;

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text fileb| PDFc| 16.94 MB2| rda;

490 1 a| ECU Brody School of Medicine dissertation;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| Ph.D.c| East Carolina Universityd| 2019.;

500 a| Presented to the faculty of the Department of Anatomy and Cell Biology;

500 a| Advisor: Christopher B. Geyer;

500 a| Title from PDF t.p. (viewed February 10, 2020).;

520 3 a| Stem, progenitor, and differentiating spermatogonia are formed in the neonatal mouse testis, and they provide the foundation for spermatogenesis and life-long fertility. Currently, the factors that regulate these varying spermatogonial fates, in particular the molecular mediators that regulate spermatogonial differentiation, are poorly understood. Our lab previously reported that retinoic acid (RA) activates kinase signaling pathways to stimulate synthesis of proteins required for spermatogonial differentiation. The work presented here extends those findings, and is organized into chapters. In chapters 1-2, I present published studies describing key roles for 'mechanistic target of rapamycin kinase' (MTOR) and 'regulatory associated protein of MTOR, complex 1' (RPTOR) in normal spermatogonial development in vivo. In chapter 3, I present the results from an unbiased RNA-seq analysis of testicular gene expression in the fetal and neonatal mouse testis prior to establishment of the spermatogonial pool.;

504 a| Includes bibliographical references.;

650 2 a| Spermatogonia.=| ^A1374356;

650 2 a| Regulatory-Associated Protein of mTOR.=| ^A1391322;

650 2 a| Sirolimus.=| ^A936018;

650 2 a| Transcriptome.=| ^A1337707;

650 2 a| MTOR protein, human.?| UNAUTHORIZED;

650 2 a| TOR Serine-Threonine Kinases.=| ^A1205549;

650 2 a| Testis.=| ^A919554;

653 a| Spermatogenesis;

653 a| Reproduction;

653 a| Development;

653 a| Prospermatogonia;

653 a| Differentiation;

700 1 a| Geyer, Christopher B.,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Anatomy and Cell Biology.?| UNAUTHORIZED;

830 0 a| ECU Brody School of Medicine dissertation.?| UNAUTHORIZED;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/7441;

949 o| wjh;

994 a| C0b| ERE;

096 a| WJ 834;

596 a| 1 4;

998 a| 5168910;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5168910-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 8/27/2019x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5168910-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 8/27/2019x| ETDz| HERESOURCE;

The mechanistic target of rapamycin (mTOR) and its complex 1 associated protein RPTOR are germ cell-autonomously required for spermatogonial development & chapter IV : investigating changes in the testicular transcriptome during the prospermatogonial transition / by Nicholas Serra.

Author/creator	Serra, Nicholas author.
Other author	Geyer, Christopher B., degree supervisor.
Other author	East Carolina University. Department of Anatomy and Cell Biology.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2019.
Description	211 pages : illustrations (chiefly color).
Supplemental Content	Access via ScholarShip
Subjects	Spermatogonia. Regulatory-Associated Protein of mTOR. Sirolimus. Transcriptome. MTOR protein, human. TOR Serine-Threonine Kinases. Testis.

Series	ECU Brody School of Medicine dissertation ECU Brody School of Medicine dissertation. UNAUTHORIZED
Summary	Stem, progenitor, and differentiating spermatogonia are formed in the neonatal mouse testis, and they provide the foundation for spermatogenesis and life-long fertility. Currently, the factors that regulate these varying spermatogonial fates, in particular the molecular mediators that regulate spermatogonial differentiation, are poorly understood. Our lab previously reported that retinoic acid (RA) activates kinase signaling pathways to stimulate synthesis of proteins required for spermatogonial differentiation. The work presented here extends those findings, and is organized into chapters. In chapters 1-2, I present published studies describing key roles for 'mechanistic target of rapamycin kinase' (MTOR) and 'regulatory associated protein of MTOR, complex 1' (RPTOR) in normal spermatogonial development in vivo. In chapter 3, I present the results from an unbiased RNA-seq analysis of testicular gene expression in the fetal and neonatal mouse testis prior to establishment of the spermatogonial pool.
General note	Presented to the faculty of the Department of Anatomy and Cell Biology
General note	Advisor: Christopher B. Geyer
General note	Title from PDF t.p. (viewed February 10, 2020).
Dissertation note	Ph.D. East Carolina University 2019.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

Availability

Library	Location	Call Number	Status	Item Actions
	Electronic Resources	Access Content Online	✔ Available

The mechanistic target of rapamycin (mTOR) and its complex 1 associated protein RPTOR are germ cell-autonomously required for spermatogonial development & chapter IV : investigating changes in the testicular transcriptome during the prospermatogonial transition / by Nicholas Serra.

Click here for more information about this title

Availability