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010 a| 2018001061;

020 a| 9783110469844 (hardback : alk. paper);

020 a| 3110469847 (hardback : alk. paper);

020 z| 9783110470734 (PDF);

020 z| 9783110469905 (EPUB);

020 z| 9783110470741 (set : print and ebook);

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245 00 a| Metallo-drugsh| [electronic resource] :b| development and action of anticancer agents /c| edited by Astrid Sigel, Helmut Sigel, Eva Freisinger, and Roland K.O. Sigel.;

260 a| Berlin ;a| Boston :b| De Gruyter,c| [2018];

300 a| xlii, 546 pages :b| illustrations (some color) ;c| 25 cm.;

490 0 a| Metal ions in life sciences,x| 1559-0836 ;v| volume 18;

504 a| Includes bibliographical references and index.;

506 a| Available only to authorized users.;

520 a| "Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching"--c| Provided by publisher.;

538 a| Mode of access: World Wide Web;

650 0 a| Organoplatinum compoundsx| Therapeutic use.=| ^A103828;

650 0 a| Antineoplastic agents.=| ^A1221;

650 0 a| Pharmaceutical chemistry.=| ^A1166;

650 12 a| Organoplatinum Compoundsx| therapeutic use?| UNAUTHORIZED;

650 22 a| Antineoplastic Agents=| ^A918039;

650 22 a| Cisplatin=| ^A961451;

655 0 a| Electronic books.=| ^A491897;

700 1 a| Sigel, Astrid.=| ^A12500;

700 1 a| Sigel, Helmut.=| ^A541486;

700 1 a| Freisinger, Eva.?| UNAUTHORIZED;

700 1 a| Sigel, Roland K. O.=| ^A722908;

830 0 a| Metal ions in life sciencesv| v. 18.x| 1559-0836=| ^A722907;

856 40 z| Full text available from Ebook Central - Academic Completeu| https://ebookcentral.proquest.com/lib/eastcarolina/detail.action?docID=5157376;

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Metallo-drugs development and action of anticancer agents / edited by Astrid Sigel, Helmut Sigel, Eva Freisinger, and Roland K.O. Sigel.

Format	Electronic
Publication Info	Berlin ; Boston : De Gruyter, [2018]
Description	xlii, 546 pages : illustrations (some color) ; 25 cm.
Supplemental Content	Full text available from Ebook Central - Academic Complete
Subjects	Organoplatinum compounds--Therapeutic use. Antineoplastic agents. Pharmaceutical chemistry. Organoplatinum Compounds--therapeutic use. Antineoplastic Agents Cisplatin

Other author/creator	Sigel, Astrid.
Other author/creator	Sigel, Helmut.
Other author/creator	Freisinger, Eva.
Other author/creator	Sigel, Roland K. O.
Series	Metal ions in life sciences, 1559-0836 ; volume 18 Metal ions in life sciences v. 18. 1559-0836 ^A722907
Abstract	"Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching"-- Provided by publisher.
Bibliography note	Includes bibliographical references and index.
Access restriction	Available only to authorized users.
Technical details	Mode of access: World Wide Web
Genre/form	Electronic books.
LCCN	2018001061
ISBN	9783110469844 (hardback : alk. paper)
ISBN	3110469847 (hardback : alk. paper)

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Metallo-drugs development and action of anticancer agents / edited by Astrid Sigel, Helmut Sigel, Eva Freisinger, and Roland K.O. Sigel.

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