Contents |
Drug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective. |
Bibliography note | Includes bibliographical references and index. |
Access restriction | Available only to authorized users. |
Technical details | Mode of access: World Wide Web |
Source of description | Description based on print version record and CIP data provided by publisher. |
Issued in other form | Print version: El-Kattan, Ayman F., author. Oral bioavailability assessment Hoboken, NJ : John Wiley & Sons Inc., 2017 9781118916698 |
Genre/form | Electronic books. |
LCCN | 2016056137 |
ISBN | 9781118916940 (Adobe PDF) |
ISBN | 9781118916933 (ePub) |