Tools

LEADER 02983cam a2200481Ii 4500

001 ocn988775848;

003 OCoLC;

005 20170914030100.0;

006 m o d ;

007 cr unu||||||||;

008 170602s2017 ncua obm 000 0 eng d;

035 a| (Sirsi) o988775848;

035 a| (OCoLC)988775848;

049 a| EREE;

090 a| QD501;

100 1 a| McAteer, Donald,e| author.?| UNAUTHORIZED;

245 10 a| Platinum-catalyzed acylation of 2-(aryloxy)pyridines via direct carbon-hydrogen activation /c| by Donald McAteer.;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2017.;

300 a| 76 pages :b| illustrations (some color);

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text fileb| PDFc| 3.49 MB2| rda;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| M.S.c| East Carolina Universityd| 2017.;

500 a| Presented to the faculty of the Department of Chemistry.;

500 a| Advisor: Shouquan Huo.;

500 a| Title from PDF t.p. (viewed June 19, 2017).;

520 3 a| Carbonyl groups are ubiquitous in pharmaceuticals, biomolecules, and natural products. The traditional means of acylation to introduce carbonyls, such as the Friedel-Crafts acylation, can be limited in scope. More recent methods using transition metals to catalyze direct C-H acylation have opened up new opportunities in synthesis, but often require the use of additives in the form of oxidants or expensive silver salts. In this report, a new reaction was developed in which platinum was used as the catalyst to introduce an acyl group to the ortho position of 2-(aryloxy)pyridines with acyl chlorides as the acylating reagent. This reaction occurs via direct carbon-hydrogen bond activation and does not require the use of additives. The reaction was found to allow for double acylation of the ortho position when both sites are available and not sterically hindered. After optimization of the reaction conditions, double acylated and single acylated compounds were synthesized successfully using aliphatic, aromatic, and [alpha],[beta]-unsaturated acyl chlorides as the acylating reagents.;

504 a| Includes bibliographical references.;

650 0 a| Platinum catalysts.=| ^A1345129;

650 0 a| Acylation.=| ^A1345027;

700 1 a| Huo, Shouquan,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Chemistry.?| UNAUTHORIZED;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/6186;

949 o| wjh;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 4704168;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4704168-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 6/2/2017x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4704168-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 6/2/2017x| ETDz| HERESOURCE;

Platinum-catalyzed acylation of 2-(aryloxy)pyridines via direct carbon-hydrogen activation / by Donald McAteer.

Author/creator	McAteer, Donald author.
Other author	Huo, Shouquan, degree supervisor.
Other author	East Carolina University. Department of Chemistry.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2017.
Description	76 pages : illustrations (some color)
Supplemental Content	Access via ScholarShip
Subjects	Platinum catalysts. Acylation.

Summary	Carbonyl groups are ubiquitous in pharmaceuticals, biomolecules, and natural products. The traditional means of acylation to introduce carbonyls, such as the Friedel-Crafts acylation, can be limited in scope. More recent methods using transition metals to catalyze direct C-H acylation have opened up new opportunities in synthesis, but often require the use of additives in the form of oxidants or expensive silver salts. In this report, a new reaction was developed in which platinum was used as the catalyst to introduce an acyl group to the ortho position of 2-(aryloxy)pyridines with acyl chlorides as the acylating reagent. This reaction occurs via direct carbon-hydrogen bond activation and does not require the use of additives. The reaction was found to allow for double acylation of the ortho position when both sites are available and not sterically hindered. After optimization of the reaction conditions, double acylated and single acylated compounds were synthesized successfully using aliphatic, aromatic, and [alpha],[beta]-unsaturated acyl chlorides as the acylating reagents.
General note	Presented to the faculty of the Department of Chemistry.
General note	Advisor: Shouquan Huo.
General note	Title from PDF t.p. (viewed June 19, 2017).
Dissertation note	M.S. East Carolina University 2017.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

Availability

Library	Location	Call Number	Status	Item Actions
	Electronic Resources	Access Content Online	✔ Available

Platinum-catalyzed acylation of 2-(aryloxy)pyridines via direct carbon-hydrogen activation / by Donald McAteer.

Click here for more information about this title

Availability