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001 ocn988775836;

003 OCoLC;

005 20170914030101.0;

006 m o d ;

007 cr unu||||||||;

008 170602s2017 ncuad obm 000 0 eng d;

035 a| (Sirsi) o988775836;

035 a| (OCoLC)988775836;

049 a| EREE;

090 a| RS 201b| .N35;

100 1 a| Boyd, Christopher Michael,e| author.?| UNAUTHORIZED;

245 10 a| Modification of cell survival rates by cerium oxide nanoparticles for exposure to proton radiation /c| by Christopher Michael Boyd.;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2017.;

300 a| 102 pages;

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text fileb| PDFc| 1.89 MB2| rda;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| Ph. D.c| East Carolina Universityd| 2017;

504 a| Includes bibliographical references.;

520 3 a| Radiation therapy is a well-established and widely used treatment for a variety of malignancies in the human body. Current radiotherapy methods most frequently use x-rays to deliver a lethal dose to tumors with sufficient energy to initiate apoptosis in the tumor cells. The use of charged particle radiation, instead of x-rays, has become increasingly more common over the last decade to reduce damage to healthy tissue during treatment. Metallic nanoparticles and their potential applications as radioprotectors and/or radiosensitizers have also become expanding areas of research in radiation therapy. Much of the research on nanoparticles as radiosensitizers has focused on their use with photon radiotherapy, and very few studies have been conducted to investigate nanoparticle treatments with particle radiation. In this study, we have developed experiments to test the effects of various cerium oxide nanoparticle types in the 22Rv1, MCF7, and 184A1 cell lines. Tumor cells cultured in the ECU Cell Culture Laboratory were irradiated in the ECU Particle Accelerator Laboratory. Cell damage was assessed by multiple assays. Results indicate that radiosensitization to proton radiation by cerium oxide nanoparticle treatment is highly dependent upon the cell line, the type of nanoparticles administered, and the concentration of the nanoparticles that were administered.;

653 a| nanoparticles;

653 a| cerium oxide;

653 a| CNP;

653 a| proton radiation;

653 a| 184A1;

653 a| 22Rv1;

653 a| MCF7;

710 2 a| East Carolina University.b| Department of Physics.?| UNAUTHORIZED;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/6145;

949 o| wjh;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 4704162;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4704162-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 6/2/2017x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4704162-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 6/2/2017x| ETDz| HERESOURCE;

Modification of cell survival rates by cerium oxide nanoparticles for exposure to proton radiation / by Christopher Michael Boyd.

Author/creator	Boyd, Christopher Michael author.
Other author	East Carolina University. Department of Physics.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2017.
Description	102 pages
Supplemental Content	Access via ScholarShip

Summary	Radiation therapy is a well-established and widely used treatment for a variety of malignancies in the human body. Current radiotherapy methods most frequently use x-rays to deliver a lethal dose to tumors with sufficient energy to initiate apoptosis in the tumor cells. The use of charged particle radiation, instead of x-rays, has become increasingly more common over the last decade to reduce damage to healthy tissue during treatment. Metallic nanoparticles and their potential applications as radioprotectors and/or radiosensitizers have also become expanding areas of research in radiation therapy. Much of the research on nanoparticles as radiosensitizers has focused on their use with photon radiotherapy, and very few studies have been conducted to investigate nanoparticle treatments with particle radiation. In this study, we have developed experiments to test the effects of various cerium oxide nanoparticle types in the 22Rv1, MCF7, and 184A1 cell lines. Tumor cells cultured in the ECU Cell Culture Laboratory were irradiated in the ECU Particle Accelerator Laboratory. Cell damage was assessed by multiple assays. Results indicate that radiosensitization to proton radiation by cerium oxide nanoparticle treatment is highly dependent upon the cell line, the type of nanoparticles administered, and the concentration of the nanoparticles that were administered.
Dissertation note	Ph. D. East Carolina University 2017
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

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Modification of cell survival rates by cerium oxide nanoparticles for exposure to proton radiation / by Christopher Michael Boyd.

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