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016 7 a| 10271159262| DE-101;

016 7 a| 1016115692| DNLM;

016 7 a| 0163004202| Uk;

020 a| 9783527332557q| (print ;q| alk. paper);

020 a| 3527332553q| (print ;q| alk. paper);

020 z| 9783527670390q| (ePDF);

020 z| 9783527670406q| (epub);

020 z| 9783527670413q| (mobi);

020 z| 9783527670383q| (oBook);

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245 00 a| Trypanosomatid diseasesh| [electronic resource] :b| molecular routes to drug discovery /c| edited by Timo Jäger, Oliver Koch, and Leopold Flohé.;

260 a| Weinheim, Germany :b| Wiley-Blackwell,c| [2013];

300 a| xxviii, 547 pages :b| illustrations,c| 27 cm.;

490 0 a| Drug discovery in infectious diseases ;v| volume 4;

504 a| Includes bibliographical references and index.;

505 0 a| Pt.I: Disease burder, current treatments, medical needs, and strategic approaches. Visceral leishmaniasis -- current treatments and needs / Poonam Salotra, Ruchi Sing and Karin Seifert* -- Chemotherapy of leishmaniasis: a veterinary perspective / María Jesús Corral-Caridad and José María Alunda* -- Pharmacological metabolomics in trypanosomes / Darren J. Creek, Isabel M. Vincent, and Michael P. Barrett* -- Drug design and screening by In Silico approaches / Mattía Morí and Maurizío Botta* -- Computational approaches and collaborative drug discovery for trypanosomal diseases / Sean Elkins* and Barry A Bunin. Pt. II: Metabolic peculiarities in the trypanosomatid family guided drug discovery. Interaction of leishmania parasites with host cells and its functional consequences / Uta Schuright, Anita Masic and Heidrun Moll* -- Function of glycosomes in the metabolism of trypanosomatid parasites and the promise of glycosomal proteins as drug targets / Melisa Gualdrón-López, Paul A.M. Michels*, Wilfredo Quiñones, Ana J. Cáceres, Luísana Avilán, and Juan-Luis Concepción -- Clyxalase enzymes in trypanosomatids / Maria Sousa Silva, António E.N. Ferreira, Ricardo Gomes, Ana M. Tomás, Ana Ponces Freire, and Carlos Cordeiro* -- Trypanothione-based redox metabolism of trypanosomatids / Marcelo A. Comini* and Leopold Flohé -- Thiol peroxidases of trypanosomatids / Helena Castro* and Ana M. Tomás -- Peroxynitrite as a cytotoxic effector against trypanosoma cruzi: oxidative killing and antioxidant resistance mechanisms / Madia Trujillo, Maria Noel Alvarez, Lucia Piacenza, Martin Hugo, Ganzalo Peluffo and Rafael Radi* -- Selenoproteome of Kkinetoplastids / Alexei V. Labanov and Vadim N. Gladyshev* -- Republican machinery of Kinetoplastids DNA / Rachel Bezalel-Buch, Nurit Yaffe, and Joseph Shlomai* -- Life and death of Trypanosoma brucei: new perspectives for drug development / Torsten Barth, Jasmin Stein, Stefan Mogk, Caroline Schönfeld, Bruno K. Kubata, and Michael Duszenko*.;

505 0 a| Pt. III: Validation and selection of drug targets in Kinetoplasts. Rational selection of anti-microbial drug targets: unique or conserved? /Boris Rodenko and Harry P. de Koning* -- Drug targets in Trypanosomal and Leishmanial Pentose Phosphate pathway / Marcelo A. Comini*, Cecilia Ortiz, and Juan José Cazzulo -- GDP-Mannose: A key point for target identification and drug design in Kinetoplastids / Sébastien Pomel* and Philippe M. Loiseau -- Transporters in anti-parasitic drug development and resistance / Vincent Delespaux and Harry P. de Koning* -- Peptidases in autophagy are therapeutic targets for Leishmaniasis / Roderick A.M. Williams* -- Proteases of Trypanosoma brucei / Dietmar Steverding*. Pt. IV: Examples of target-based approaches and compounds under consideration. Screening approaches towards Trypanothione Reductase / Mathias Beig, Frank Oellien, R. Luise Krauth-Siegel, and Paul M. Selzer* -- Redox-active agents in reactions involving the Trypanothione/Trypanothione Reductase-based system to fight Kinetoplastidal parasites / Thibault Gendron, Don Antoine Lanfranchi, and Elisabeth Davioud-Charvet* -- Inhibition of Trypanothione synthetase as a therapeutic concept / Oliver Koch*, Timo Jäger, Leopold Flohé and Paul M. Selzer -- Targeting the trypanosomatidic enzymes Pteridine reductase and Dihydrofolate reductase / Stefania Ferrari, Valeria Lasasso, Puneet Saxena and Maria Paolo Costi* -- Contribution to new therapies for Chagas disease / Patricia S. Doyle* and Juan C. Engel -- Ergosterol biosynthesis for the specific treatment of Chagas disease: from basic science to clinical trials / Julio A. Urbina* -- New developments in the treatment of late-stage human African Trypanosomiasis / Cyrus J. Bacchi, Robert T. Jacobs, and Nigel Yarlett*.;

506 a| Available only to authorized users.;

538 a| Mode of access: World Wide Web;

650 0 a| Trypanosomiasisx| Chemotherapy.=| ^A166099;

650 0 a| Drug development.=| ^A443888;

650 12 a| Trypanosomiasisx| drug therapy?| UNAUTHORIZED;

650 22 a| Drug Discoveryx| methods=| ^A1023263;

650 6 a| Trypanosomiasex| Chimiothérapie.;

650 6 a| Médicamentsx| Développement.;

650 7 a| Drug development.2| fast0| (OCoLC)fst00898670;

655 0 a| Electronic books.=| ^A491897;

700 1 a| Jäger, Timo.?| UNAUTHORIZED;

700 1 a| Koch, Oliverc| (Pharmacist).1| https://id.oclc.org/worldcat/entity/E39PCjwHCdRP49tD88BwjYxyHP.?| UNAUTHORIZED;

710 2 a| European Cooperation in the Field of Scientific and Technical Research (Organization)=| ^A857625;

758 i| has work:a| Trypanosomatid diseases (Text)1| https://id.oclc.org/worldcat/entity/E39PCGP6YMPjj7D6pybJ4bbRgC4| https://id.oclc.org/worldcat/ontology/hasWork;

830 0 a| Drug discovery in infectious diseases ;v| v. 4.?| UNAUTHORIZED;

856 40 z| Full text available from Ebook Central - Academic Completeu| https://ebookcentral.proquest.com/lib/eastcarolina/detail.action?docID=1157730;

947 a| (OCoLC)ocn843345756;

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Trypanosomatid diseases molecular routes to drug discovery / edited by Timo Jäger, Oliver Koch, and Leopold Flohé.

Format	Electronic
Publication Info	Weinheim, Germany : Wiley-Blackwell, [2013]
Description	xxviii, 547 pages : illustrations, 27 cm.
Supplemental Content	Full text available from Ebook Central - Academic Complete
Subjects	Trypanosomiasis--Chemotherapy. Drug development. Trypanosomiasis--drug therapy. Drug Discovery--methods. Trypanosomiase--Chimiothérapie. Médicaments--Développement.

Other author/creator	Jäger, Timo.
Other author/creator	Koch, Oliver (Pharmacist). https://id.oclc.org/worldcat/entity/E39PCjwHCdRP49tD88BwjYxyHP.
Other author/creator	Flohé, L. (Leopold), 1938. https://id.oclc.org/worldcat/entity/E39PBJjhCqxhctrM9fHf3CJVYP.
Other author/creator	European Cooperation in the Field of Scientific and Technical Research (Organization)
Series	Drug discovery in infectious diseases ; volume 4 Drug discovery in infectious diseases ; v. 4. UNAUTHORIZED
Contents	Pt.I: Disease burder, current treatments, medical needs, and strategic approaches. Visceral leishmaniasis -- current treatments and needs / Poonam Salotra, Ruchi Sing and Karin Seifert* -- Chemotherapy of leishmaniasis: a veterinary perspective / María Jesús Corral-Caridad and José María Alunda* -- Pharmacological metabolomics in trypanosomes / Darren J. Creek, Isabel M. Vincent, and Michael P. Barrett* -- Drug design and screening by In Silico approaches / Mattía Morí and Maurizío Botta* -- Computational approaches and collaborative drug discovery for trypanosomal diseases / Sean Elkins* and Barry A Bunin. Pt. II: Metabolic peculiarities in the trypanosomatid family guided drug discovery. Interaction of leishmania parasites with host cells and its functional consequences / Uta Schuright, Anita Masic and Heidrun Moll* -- Function of glycosomes in the metabolism of trypanosomatid parasites and the promise of glycosomal proteins as drug targets / Melisa Gualdrón-López, Paul A.M. Michels, Wilfredo Quiñones, Ana J. Cáceres, Luísana Avilán, and Juan-Luis Concepción -- Clyxalase enzymes in trypanosomatids / Maria Sousa Silva, António E.N. Ferreira, Ricardo Gomes, Ana M. Tomás, Ana Ponces Freire, and Carlos Cordeiro -- Trypanothione-based redox metabolism of trypanosomatids / Marcelo A. Comini* and Leopold Flohé -- Thiol peroxidases of trypanosomatids / Helena Castro* and Ana M. Tomás -- Peroxynitrite as a cytotoxic effector against trypanosoma cruzi: oxidative killing and antioxidant resistance mechanisms / Madia Trujillo, Maria Noel Alvarez, Lucia Piacenza, Martin Hugo, Ganzalo Peluffo and Rafael Radi* -- Selenoproteome of Kkinetoplastids / Alexei V. Labanov and Vadim N. Gladyshev* -- Republican machinery of Kinetoplastids DNA / Rachel Bezalel-Buch, Nurit Yaffe, and Joseph Shlomai* -- Life and death of Trypanosoma brucei: new perspectives for drug development / Torsten Barth, Jasmin Stein, Stefan Mogk, Caroline Schönfeld, Bruno K. Kubata, and Michael Duszenko*.
Contents	Pt. III: Validation and selection of drug targets in Kinetoplasts. Rational selection of anti-microbial drug targets: unique or conserved? /Boris Rodenko and Harry P. de Koning* -- Drug targets in Trypanosomal and Leishmanial Pentose Phosphate pathway / Marcelo A. Comini, Cecilia Ortiz, and Juan José Cazzulo -- GDP-Mannose: A key point for target identification and drug design in Kinetoplastids / Sébastien Pomel and Philippe M. Loiseau -- Transporters in anti-parasitic drug development and resistance / Vincent Delespaux and Harry P. de Koning* -- Peptidases in autophagy are therapeutic targets for Leishmaniasis / Roderick A.M. Williams* -- Proteases of Trypanosoma brucei / Dietmar Steverding. Pt. IV: Examples of target-based approaches and compounds under consideration. Screening approaches towards Trypanothione Reductase / Mathias Beig, Frank Oellien, R. Luise Krauth-Siegel, and Paul M. Selzer -- Redox-active agents in reactions involving the Trypanothione/Trypanothione Reductase-based system to fight Kinetoplastidal parasites / Thibault Gendron, Don Antoine Lanfranchi, and Elisabeth Davioud-Charvet* -- Inhibition of Trypanothione synthetase as a therapeutic concept / Oliver Koch, Timo Jäger, Leopold Flohé and Paul M. Selzer -- Targeting the trypanosomatidic enzymes Pteridine reductase and Dihydrofolate reductase / Stefania Ferrari, Valeria Lasasso, Puneet Saxena and Maria Paolo Costi -- Contribution to new therapies for Chagas disease / Patricia S. Doyle* and Juan C. Engel -- Ergosterol biosynthesis for the specific treatment of Chagas disease: from basic science to clinical trials / Julio A. Urbina* -- New developments in the treatment of late-stage human African Trypanosomiasis / Cyrus J. Bacchi, Robert T. Jacobs, and Nigel Yarlett*.
Bibliography note	Includes bibliographical references and index.
Access restriction	Available only to authorized users.
Technical details	Mode of access: World Wide Web
Genre/form	Electronic books.
LCCN	2023496406
ISBN	9783527332557 (print ; alk. paper)
ISBN	3527332553 (print ; alk. paper)
ISBN	(ePDF)
ISBN	(epub)
ISBN	(mobi)
ISBN	(oBook)

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Trypanosomatid diseases molecular routes to drug discovery / edited by Timo Jäger, Oliver Koch, and Leopold Flohé.

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