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245 00 a| Principles for modelling dose-response for the risk assessment of chemicalsh| [electronic resource] /c| first draft prepared by the WHO Task Group on Environmental Health Criteria on Principles for Modelling Dose-Response for the Risk Assessment of Chemicals.;

260 a| Geneva, Switzerland :b| World Health Organization,;

300 a| xx, 137 p. :b| ill. (some col.), charts ;c| 21 cm.;

490 1 a| Environmental health criteria,x| 0250-863X ;v| 239;

500 a| "Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals.";

504 a| Includes bibliographical references (p. 103-110).;

505 2 a| Summary, conclusions, and recommendations -- Introduction -- Risk analysis -- Dose-response modelling : basic concepts -- Dose-response modelling : why and when to use it -- Principles of dose-response modelling -- Communicating the results of dose-response modelling -- Conclusions and recommendations.;

506 a| Available only to authorized users.;

520 3 a| This volume is part of the ongoing review of the underlying scientific bases for decision-making in chemical risk assessment by International Program on Chemical Safety. It involves specific consideration of the area of dose-response assessment in the evaluation of information from toxicological studies in animals and from human clinical and epidemiological studies. It covers toxicants with threshold effects and those for which there may be no practical threshold, such as substances that are genotoxic and carcinogenic. The discussions are concerned with that subset of cause-effect relationships commonly referred to as dose-response models, which are typically used to characterize the biological effects of intentional (e.g. drugs and nutrients) and unintentional (e.g. contaminants) exposure to chemicals. This report is intended primarily to provide descriptive guidance for risk assessors in using dose-response modeling in hazard characterization. It will also provide mathematical modelers with an appreciation of issues to be considered when modeling in the context of the risk assessment process. Risk managers will be able to obtain a general understanding of the applications and limitations of dose-response modeling. For both risk assessors and risk managers, some considerations for communicating the results of risk assessments that use dose-response modeling are presented.--Publisher's description.;

530 a| Also available online.;

538 a| Mode of access: World Wide Web;

650 0 a| Drugsx| Dose-response relationship.=| ^A114143;

650 0 a| Risk assessment.=| ^A221641;

650 12 a| Dose-Response Relationship, Drug.=| ^A920467;

650 12 a| Dose-Response Relationship, Radiation.=| ^A926151;

650 12 a| Risk Assessment.=| ^A929045;

650 12 a| Environmental exposure.=| ^A919733;

655 0 a| Electronic books.=| ^A491897;

710 2 a| World Health Organization.=| ^A1132;

710 2 a| United Nations Environment Programme.=| ^A14687;

710 2 a| International Labour Organisation.=| ^A14707;

710 2 a| Inter-Organization Programme for the Sound Management of Chemicals.=| ^A460860;

830 0 a| Environmental health criteria ;v| 239.=| ^A14705;

856 40 z| Full text available from Ebook Central - Academic Completeu| https://ebookcentral.proquest.com/lib/eastcarolina/detail.action?docID=476144;

947 a| (OCoLC)ocn264018462;

949 a| CLICK ON WEB ADDRESSw| ASISh| JOYNER188;

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999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4675138-2001l| HSLELECm| HSLr| Ys| Yt| HEBKu| 3/22/2017x| EBOOKz| HERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4675138-3001l| MNETm| JMUSICr| Ys| Yt| MNESSBKu| 3/22/2017x| EBOOKz| JERESOURCE;

Principles for modelling dose-response for the risk assessment of chemicals / first draft prepared by the WHO Task Group on Environmental Health Criteria on Principles for Modelling Dose-Response for the Risk Assessment of Chemicals.

Format	Electronic
Publication Info	Geneva, Switzerland : World Health Organization,
Description	xx, 137 p. : ill. (some col.), charts ; 21 cm.
Supplemental Content	Full text available from Ebook Central - Academic Complete
Subjects	Drugs--Dose-response relationship. Risk assessment. Dose-Response Relationship, Drug. Dose-Response Relationship, Radiation. Risk Assessment. Environmental exposure.

Other author/creator	World Health Organization.
Other author/creator	United Nations Environment Programme.
Other author/creator	International Labour Organisation.
Other author/creator	Inter-Organization Programme for the Sound Management of Chemicals.
Series	Environmental health criteria, 0250-863X ; 239 Environmental health criteria ; 239. ^A14705
Partial contents	Summary, conclusions, and recommendations -- Introduction -- Risk analysis -- Dose-response modelling : basic concepts -- Dose-response modelling : why and when to use it -- Principles of dose-response modelling -- Communicating the results of dose-response modelling -- Conclusions and recommendations.
Summary	This volume is part of the ongoing review of the underlying scientific bases for decision-making in chemical risk assessment by International Program on Chemical Safety. It involves specific consideration of the area of dose-response assessment in the evaluation of information from toxicological studies in animals and from human clinical and epidemiological studies. It covers toxicants with threshold effects and those for which there may be no practical threshold, such as substances that are genotoxic and carcinogenic. The discussions are concerned with that subset of cause-effect relationships commonly referred to as dose-response models, which are typically used to characterize the biological effects of intentional (e.g. drugs and nutrients) and unintentional (e.g. contaminants) exposure to chemicals. This report is intended primarily to provide descriptive guidance for risk assessors in using dose-response modeling in hazard characterization. It will also provide mathematical modelers with an appreciation of issues to be considered when modeling in the context of the risk assessment process. Risk managers will be able to obtain a general understanding of the applications and limitations of dose-response modeling. For both risk assessors and risk managers, some considerations for communicating the results of risk assessments that use dose-response modeling are presented.--Publisher's description.
General note	"Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals."
Bibliography note	Includes bibliographical references (p. 103-110).
Access restriction	Available only to authorized users.
Other forms	Also available online.
Technical details	Mode of access: World Wide Web
Genre/form	Electronic books.
LCCN	2010369282
ISBN	9789241572392
ISBN	9241572396

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Principles for modelling dose-response for the risk assessment of chemicals / first draft prepared by the WHO Task Group on Environmental Health Criteria on Principles for Modelling Dose-Response for the Risk Assessment of Chemicals.

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