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010 a| 2017300024;

020 a| 9780128033197q| (hardback);

020 z| 9780128033265q| (electronic bk.);

020 z| 0128033266q| (electronic bk.);

035 a| (WaSeSS)ssj0001730412;

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049 a| EREEa| NEHH;

050 00 a| QP92b| .H4423 2016;

245 00 a| Hematopoiesish| [electronic resource] /c| edited by Emery H. Bresnick, University of Wisconsin School of Medicine and Public Health, UW-Carbone Cancer Center; and UW-Madison Blood Research Program, Madison, WI, United States.;

250 a| First edition.;

260 a| Amsterdama| Boston :b| Academic Press is an imprint of Elsevier,c| [2016].;

300 a| xiii, 278 pages, [16] pages of unnumbered plates :b| illustrations (some color) ;c| 24 cm.;

490 0 a| Current topics in developmental biology ;v| volume 118;

504 a| Includes bibliographical references and index.;

505 0 a| Regulation of blood stem cell development / E. Dzierzak and E. de Pater -- Hematopoietic stem cell and its bone marrow niche / V.W.C. Yu and D.T. Scadden -- The hematopoietic stem and progenitor cell cistrome : GATA factor-dependent cis-Regulatory mechanisms / K.J. Hewitt, K.D. Johnson, X. Gao, S. Keles, and E.H. Bresnick -- ETS transcription factor ETV2/ER71/Etsrp in hematopoietic and vascular development / S. Sumanas and K. Choi -- Taking the leap : Runx1 in the formation of blood from endothelium / J. Tober, M.W. Maijenburg, and N.A. Speck -- SCL/TAL1 in hematopoiesis and cellular reprogramming / T. Hoang, J.A. Lambert, and R. Martin -- Navigating transcriptional coregulator ensembles to establish genetic networks : a GATA factor perspective / A.W. DeVilbiss, N. Tanimura, S.C. McIver, K.R. Katsumura, K.D. Johnson, and E.H. Bresnick -- Noncoding regulatory RNAs in hematopoiesis / M. Jeong and M.A. Goodell.;

506 a| Available only to authorized users.;

520 a| "The process of developing the diverse blood cell repertoire from stem and progenitor cells termed hematopoiesis has been subject to considerable investigation. However, key steps in the complex process of hematopoiesis, including hematopoietic stem sell generation during embryogenesis, hematopoietic stem and progenitor cell expansion to accommodate physiological and pathological requirements, and mechanisms that ensure hematopoietic stem and progenitor cell phenotypic integrity, remain incompletely understood. Elucidating these mechanisms will yield concepts that can be extrapolated to diverse biological realms, and given the vital importance of the hematopoietic system, future efforts will invariably lead to medical breakthroughs that advance human health. This issue of Current Topic in Developmental Biology reviews cutting-edge research on mechanistic and biological aspects of hematopoiesis. The initial chapters lay the groundwork for understanding the cellular origin of hematopoietic stem cells and the pivotal role of the microenvironment or "niche" in non-cell-autonomously regulating hematopoietic stem cell genesis and function. The next series of chapters probe into molecular mechanisms governing the development of hematopoietic stem and progenitor cells and for maintaining their unique phenotypes." -- Publisher's description;

538 a| Mode of access: World Wide Web;

650 0 a| Hematopoiesis.=| ^A56193;

650 7 a| Hematopoiesis.2| fast0| (OCoLC)fst00954922;

655 0 a| Electronic books.=| ^A491897;

700 1 a| Bresnick, Emery.?| UNAUTHORIZED;

856 40 z| Full text available from Book Series Package - Life Sciences [BSLFSC]u| https://go.openathens.net/redirector/ecu.edu?url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Fbookseries%2F00702153%2F118;

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999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4580121-1001l| JNETm| JOYNERr| Ys| Yt| JNESSBKu| 11/22/2016x| EBOOKz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4580121-2001l| HSLELECm| HSLr| Ys| Yt| HEBKu| 11/22/2016x| EBOOKz| HERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4580121-3001l| MNETm| JMUSICr| Ys| Yt| MNESSBKu| 11/22/2016x| EBOOKz| JERESOURCE;

Hematopoiesis / edited by Emery H. Bresnick, University of Wisconsin School of Medicine and Public Health, UW-Carbone Cancer Center; and UW-Madison Blood Research Program, Madison, WI, United States.

Other author	Bresnick, Emery.
Format	Electronic
Edition	First edition.
Publication Info	Amsterdam Boston : Academic Press is an imprint of Elsevier, [2016].
Description	xiii, 278 pages, [16] pages of unnumbered plates : illustrations (some color) ; 24 cm.
Supplemental Content	Full text available from Book Series Package - Life Sciences [BSLFSC]
Subjects	Hematopoiesis.

Series	Current topics in developmental biology ; volume 118
Contents	Regulation of blood stem cell development / E. Dzierzak and E. de Pater -- Hematopoietic stem cell and its bone marrow niche / V.W.C. Yu and D.T. Scadden -- The hematopoietic stem and progenitor cell cistrome : GATA factor-dependent cis-Regulatory mechanisms / K.J. Hewitt, K.D. Johnson, X. Gao, S. Keles, and E.H. Bresnick -- ETS transcription factor ETV2/ER71/Etsrp in hematopoietic and vascular development / S. Sumanas and K. Choi -- Taking the leap : Runx1 in the formation of blood from endothelium / J. Tober, M.W. Maijenburg, and N.A. Speck -- SCL/TAL1 in hematopoiesis and cellular reprogramming / T. Hoang, J.A. Lambert, and R. Martin -- Navigating transcriptional coregulator ensembles to establish genetic networks : a GATA factor perspective / A.W. DeVilbiss, N. Tanimura, S.C. McIver, K.R. Katsumura, K.D. Johnson, and E.H. Bresnick -- Noncoding regulatory RNAs in hematopoiesis / M. Jeong and M.A. Goodell.
Abstract	"The process of developing the diverse blood cell repertoire from stem and progenitor cells termed hematopoiesis has been subject to considerable investigation. However, key steps in the complex process of hematopoiesis, including hematopoietic stem sell generation during embryogenesis, hematopoietic stem and progenitor cell expansion to accommodate physiological and pathological requirements, and mechanisms that ensure hematopoietic stem and progenitor cell phenotypic integrity, remain incompletely understood. Elucidating these mechanisms will yield concepts that can be extrapolated to diverse biological realms, and given the vital importance of the hematopoietic system, future efforts will invariably lead to medical breakthroughs that advance human health. This issue of Current Topic in Developmental Biology reviews cutting-edge research on mechanistic and biological aspects of hematopoiesis. The initial chapters lay the groundwork for understanding the cellular origin of hematopoietic stem cells and the pivotal role of the microenvironment or "niche" in non-cell-autonomously regulating hematopoietic stem cell genesis and function. The next series of chapters probe into molecular mechanisms governing the development of hematopoietic stem and progenitor cells and for maintaining their unique phenotypes." -- Publisher's description
Bibliography note	Includes bibliographical references and index.
Access restriction	Available only to authorized users.
Technical details	Mode of access: World Wide Web
Genre/form	Electronic books.
LCCN	2017300024
ISBN	9780128033197 (hardback)
ISBN	(electronic bk.)
ISBN	(electronic bk.)

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Hematopoiesis / edited by Emery H. Bresnick, University of Wisconsin School of Medicine and Public Health, UW-Carbone Cancer Center; and UW-Madison Blood Research Program, Madison, WI, United States.

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