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001 ocn957491774;

003 OCoLC;

005 20161027015235.0;

006 m o d ;

007 cr unu||||||||;

008 160829s2016 ncua obm 000 0 eng d;

035 a| (Sirsi) o957491774;

035 a| (OCoLC)957491774;

049 a| EREE;

090 a| QH448.4;

100 1 a| Chen, Dongliang,e| author.?| UNAUTHORIZED;

245 10 a| Exploring the roles of horizotnal gene transfer in metazoans /c| by Dongliang Chen.;

246 3 a| Exploring the roles of horizontal gene transfer in metazoans;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2016.;

300 a| 152 pages :b| illustrations (some color);

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text fileb| PDFc| 1.59 MB2| rda;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| Ph.D.c| East Carolina Universityd| 2016.;

500 a| Presented to the faculty of the Interdisciplinary Doctoral Program in Biological Sciences in Association with the Department of Biology.;

500 a| Advisor: Jinling Huang.;

500 a| Title from PDF t.p. (viewed September 22, 2016).;

520 3 a| Horizontal gene transfer (HGT; also known as lateral gene transfer, LGT) refers to the movement of genetic information between distinct species by overcoming normal mating barriers. Historically HGT is only considered to be important in prokaryotes. Some researchers believe that eukaryotes have sexual recombination and HGT is insignificant. However, HGT has also been found to play roles in many aspects of eukaryotic evolution, like parasitism and the colonization of land by plants, although at lower frequencies than in prokaryotes. In this dissertation, I first estimated the scope of HGT in 16 selected metazoan species by genome screening using AlienG. These species are sampled to represent major lineages of metazoans. Among all the 16 species, Nematostella vectensis (4.08%) has the highest percentage of HGT genes, while parasitic Schistosoma japonicum (0.47%) ranks the lowest. In order to find out which factors are correlated with HGT rates in different species, living habitat, diet, lineage group and reproductive type were analyzed in a statistical framework. In Chapter 3 and Chapter 4, Ciona intestinalis and Trichoplax adhaerens were chosen as models to investigate horizontally acquired genes. Tunicate cellulose synthase was discovered to originate from green algae, instead from bacteria as found in previous studies. 43 genes of 21 families in T. adhaerens were found to be horizontally acquired. The functions and impacts of acquired genes on T. adhaerens are also discussed.;

504 a| Includes bibliographical references.;

650 0 a| Genetic transformation.=| ^A137175;

650 0 a| Metazoa.=| ^A45194;

650 0 a| Prokaryotes.=| ^A142147;

650 0 a| Eukaryotic cellsx| Genetics.=| ^A1244232;

653 a| Horizontal gene transfer;

653 a| HGT;

700 1 a| Huang, Jinling,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/5912;

949 o| wjh;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 4511342;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4511342-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 8/29/2016x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4511342-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 8/29/2016x| ETDz| HERESOURCE;

Exploring the roles of horizotnal gene transfer in metazoans / by Dongliang Chen.

Author/creator	Chen, Dongliang author.
Other author	Huang, Jinling, degree supervisor.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2016.
Description	152 pages : illustrations (some color)
Supplemental Content	Access via ScholarShip
Subjects	Genetic transformation. Metazoa. Prokaryotes. Eukaryotic cells--Genetics.

Variant title	Exploring the roles of horizontal gene transfer in metazoans
Summary	Horizontal gene transfer (HGT; also known as lateral gene transfer, LGT) refers to the movement of genetic information between distinct species by overcoming normal mating barriers. Historically HGT is only considered to be important in prokaryotes. Some researchers believe that eukaryotes have sexual recombination and HGT is insignificant. However, HGT has also been found to play roles in many aspects of eukaryotic evolution, like parasitism and the colonization of land by plants, although at lower frequencies than in prokaryotes. In this dissertation, I first estimated the scope of HGT in 16 selected metazoan species by genome screening using AlienG. These species are sampled to represent major lineages of metazoans. Among all the 16 species, Nematostella vectensis (4.08%) has the highest percentage of HGT genes, while parasitic Schistosoma japonicum (0.47%) ranks the lowest. In order to find out which factors are correlated with HGT rates in different species, living habitat, diet, lineage group and reproductive type were analyzed in a statistical framework. In Chapter 3 and Chapter 4, Ciona intestinalis and Trichoplax adhaerens were chosen as models to investigate horizontally acquired genes. Tunicate cellulose synthase was discovered to originate from green algae, instead from bacteria as found in previous studies. 43 genes of 21 families in T. adhaerens were found to be horizontally acquired. The functions and impacts of acquired genes on T. adhaerens are also discussed.
General note	Presented to the faculty of the Interdisciplinary Doctoral Program in Biological Sciences in Association with the Department of Biology.
General note	Advisor: Jinling Huang.
General note	Title from PDF t.p. (viewed September 22, 2016).
Dissertation note	Ph.D. East Carolina University 2016.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

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Exploring the roles of horizotnal gene transfer in metazoans / by Dongliang Chen.

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