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003 OCoLC;

005 20161027124524.0;

006 m o d ;

007 cr unu||||||||;

008 160603s2016 ncua obm 000 0 eng d;

035 a| (Sirsi) o951120033;

035 a| (OCoLC)951120033;

049 a| EREE;

100 1 a| Kim, Do Hyung,e| author.?| UNAUTHORIZED;

245 10 a| Tight junction claudin-7 protein modulates multiple processes of cancer progression in human lung cancer cells /c| by Do Hyung Kim.;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2016.;

300 a| 157 pages :b| illustrations (chiefly color);

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text fileb| PDFc| 3.97 MB2| rda;

490 1 a| ECU Brody School of Medicine dissertation;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| Ph.D.c| East Carolina Universityd| 2016.;

500 a| Presented to the academic faculty of the Department of Anatomy and Cell Biology;

500 a| Advisor: Yan-Hua Chen.;

500 a| Title from PDF t.p. (viewed June 29, 2016).;

520 3 a| Carcinogenesis usually consists of cancer initiation, promotion, and progression. Several tight junction claudin proteins have been identified as tumor suppressors or activators during cancer development. As apical proteins, tight junction claudins seal the apical sides of neighboring epithelial cells in regulating the transport of ions and fluids from the extracellular environment. However, claudin-7, which is believed to direct cell-matrix adhesion, has been found at the basal side of several human organs, including the lung. It has also been clinically reported that the low survival rate of lung cancer patients is closely associated with their low claudin-7 expression. The molecular mechanism of claudin-7 that regulates lung cancer progression is not clearly understood. In order to understand how claudin-7 is involved in lung carcinogenesis, this dissertation presents the molecular and cellular changes in human lung cancer cells upon the suppression of claudin-7 expression to study how claudin-7 modulates lung cancer cell progression, including cell proliferation, migration, and invasion, cell-matrix attachment, and cell metabolism.;

504 a| Includes bibliographical references.;

650 2 a| Neoplastic Processes.=| ^A932825;

650 2 a| Claudins.=| ^A1058127;

650 2 a| Humans.=| ^A943988;

650 2 a| Lung Neoplasms.=| ^A918448;

650 2 a| Tight Junctions.=| ^A946535;

653 a| claudin-7;

653 a| cancer;

653 a| lung;

653 a| migration;

653 a| invasion;

653 a| cell-matrix adhesion;

653 a| metabolism;

700 1 a| Chen, Yan-Hua,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Anatomy and Cell Biology.?| UNAUTHORIZED;

830 0 a| ECU Brody School of Medicine dissertation.?| UNAUTHORIZED;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/5391;

949 o| wjh;

994 a| C0b| ERE;

096 a| QZ 203;

596 a| 1 4;

998 a| 4407952;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4407952-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 6/3/2016x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4407952-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 6/3/2016x| ETDz| HERESOURCE;

Tight junction claudin-7 protein modulates multiple processes of cancer progression in human lung cancer cells / by Do Hyung Kim.

Author/creator	Kim, Do Hyung author.
Other author	Chen, Yan-Hua, degree supervisor.
Other author	East Carolina University. Department of Anatomy and Cell Biology.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2016.
Description	157 pages : illustrations (chiefly color)
Supplemental Content	Access via ScholarShip
Subjects	Neoplastic Processes. Claudins. Humans. Lung Neoplasms. Tight Junctions.

Series	ECU Brody School of Medicine dissertation ECU Brody School of Medicine dissertation. UNAUTHORIZED
Summary	Carcinogenesis usually consists of cancer initiation, promotion, and progression. Several tight junction claudin proteins have been identified as tumor suppressors or activators during cancer development. As apical proteins, tight junction claudins seal the apical sides of neighboring epithelial cells in regulating the transport of ions and fluids from the extracellular environment. However, claudin-7, which is believed to direct cell-matrix adhesion, has been found at the basal side of several human organs, including the lung. It has also been clinically reported that the low survival rate of lung cancer patients is closely associated with their low claudin-7 expression. The molecular mechanism of claudin-7 that regulates lung cancer progression is not clearly understood. In order to understand how claudin-7 is involved in lung carcinogenesis, this dissertation presents the molecular and cellular changes in human lung cancer cells upon the suppression of claudin-7 expression to study how claudin-7 modulates lung cancer cell progression, including cell proliferation, migration, and invasion, cell-matrix attachment, and cell metabolism.
General note	Presented to the academic faculty of the Department of Anatomy and Cell Biology
General note	Advisor: Yan-Hua Chen.
General note	Title from PDF t.p. (viewed June 29, 2016).
Dissertation note	Ph.D. East Carolina University 2016.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

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Tight junction claudin-7 protein modulates multiple processes of cancer progression in human lung cancer cells / by Do Hyung Kim.

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