Tools

LEADER 03302cam a2200553Ii 4500

001 ocn936213342;

003 OCoLC;

005 20170427122632.0;

006 m o d ;

007 cr unu||||||||;

008 160129s2015 ncua obm 000 0 eng d;

035 a| (Sirsi) o936213342;

035 a| (OCoLC)936213342;

049 a| EREE;

100 1 a| Busada, Jonathan Thomas,e| author.?| UNAUTHORIZED;

245 14 a| The role of retinoic acid in directing initiation of spermatogenesis in the mouse /c| Jonathan Thomas Busada.;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2015.;

300 a| 221 pages :b| illustrations (chiefly color).;

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text fileb| PDFc| 225.1 MB2| rda;

490 1 a| ECU Brody School of Medicine thesis;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| Ph. D./Au. D.c| East Carolina Universityd| 2015;

500 a| Presented to The Academic Faculty of the Department of Anatomy & Cell Biology.;

500 a| Advisor: Christopher B. Geyer.;

504 a| Includes bibliographical references.;

520 3 a| The basic tenets of gametogenesis are conserved among metazoans. After lineage commitment, germ cells proliferate, complete meiosis, and then differentiate into gametes capable of fertilization. In the mouse, spermatogenesis begins at approximately postnatal day (P) 3-4, as prospermatogonia transition into distinct populations of spermatogonia. Some prospermatogonia become spermatogonial stem cells (SSCs) that provide a consistent source of gametes throughout the male reproductive lifespan. The remaining prospermatogonia proliferate and directly differentiate (without going through an SSC stage) in response to retinoic acid (RA) to eventually enter meiosis at P10. The pathways and cellular mechanisms that direct this critical cell fate decision are poorly defined. This dissertation summarizes the results of an examination of the cellular and molecular changes that occur downstream of RA signaling that direct prospermatogonia at P0-2 to transition to differentiating spermatogonia at P3-4. The results support a novel mechanism by which RA directs spermatogonial differentiation during spermatogenesis.;

650 2 a| Spermatogenesis.=| ^A919033;

650 2 a| Tretinoin.=| ^A1289074;

650 2 a| Mice.=| ^A921375;

650 2 a| Testis.=| ^A919554;

650 2 a| Biochemical Processes.=| ^A1098929;

653 a| Retinoic Acid;

653 a| Spermatogonia;

700 1 a| Geyer, Christopher B.,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Anatomy and Cell Biology.?| UNAUTHORIZED;

830 0 a| ECU Brody School of Medicine thesis.=| ^A964744;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/5114;

994 a| C0b| ERE;

096 a| WJ 834;

596 a| 1 4;

998 a| 4356301;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4356301-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 1/29/2016x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4356301-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 1/29/2016x| ETDz| HERESOURCE;

The role of retinoic acid in directing initiation of spermatogenesis in the mouse / Jonathan Thomas Busada.

Author/creator	Busada, Jonathan Thomas author.
Other author	Geyer, Christopher B., degree supervisor.
Other author	East Carolina University. Department of Anatomy and Cell Biology.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2015.
Description	221 pages : illustrations (chiefly color).
Supplemental Content	Access via ScholarShip
Subjects	Spermatogenesis. Tretinoin. Mice. Testis. Biochemical Processes.

Series	ECU Brody School of Medicine thesis ECU Brody School of Medicine thesis. ^A964744
Summary	The basic tenets of gametogenesis are conserved among metazoans. After lineage commitment, germ cells proliferate, complete meiosis, and then differentiate into gametes capable of fertilization. In the mouse, spermatogenesis begins at approximately postnatal day (P) 3-4, as prospermatogonia transition into distinct populations of spermatogonia. Some prospermatogonia become spermatogonial stem cells (SSCs) that provide a consistent source of gametes throughout the male reproductive lifespan. The remaining prospermatogonia proliferate and directly differentiate (without going through an SSC stage) in response to retinoic acid (RA) to eventually enter meiosis at P10. The pathways and cellular mechanisms that direct this critical cell fate decision are poorly defined. This dissertation summarizes the results of an examination of the cellular and molecular changes that occur downstream of RA signaling that direct prospermatogonia at P0-2 to transition to differentiating spermatogonia at P3-4. The results support a novel mechanism by which RA directs spermatogonial differentiation during spermatogenesis.
General note	Presented to The Academic Faculty of the Department of Anatomy & Cell Biology.
General note	Advisor: Christopher B. Geyer.
Dissertation note	Ph. D./Au. D. East Carolina University 2015
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

Availability

Library	Location	Call Number	Status	Item Actions
	Electronic Resources	Access Content Online	✔ Available

The role of retinoic acid in directing initiation of spermatogenesis in the mouse / Jonathan Thomas Busada.

Click here for more information about this title

Availability