| Series |
ECU School of Nursing thesis
ECU School of Nursing thesis. UNAUTHORIZED
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| Summary |
The purpose of this study was to determine the effect of hydration on urine creatinine clearance in cancer patients receiving the chemotherapy drug cis-platinum. It is not known what effect intravenous fluids have on urine creatinine clearance results. Therefore, it was hypothesized that a higher number of patients receiving prehydration would pass their creatinine clearance test on admission. Twelve hour urine collections were used to determine renal function prior to receiving cis-platinum. The control group received no intravenous hydration prior to starting the urine collection and the experimental group received six hours of intravenous hydration prior to starting the urine collection. A total of 25 patients participated in the study. Demographic data and selected laboratory test results were obtained on 11 patients in the experimental group and 14 patients in the control group. Data were analyzed using descriptive statistics including means and percentages. Mean differences between the groups were measured with Student's t-test. Differences in proportions were measured with the Chi-square test. All p values less than 0.05 were considered significant. Overall, there were no statistically significant differences noted between the experimental group and the control group in regards to urine creatinine clearance results. This finding suggests that further research, with a larger sample size, is needed to test the assumption that patients receiving prehydration will have higher passing urine creatinine clearance. |
| General note | Submitted to the faculty of the School of Nursing. |
| General note | Advisor: Marie E. Pokorny |
| Dissertation note | M.S. East Carolina University 1991 |
| Bibliography note | Includes bibliographical references (leaves 27-32). |
| Genre/form | Academic theses. |
| Genre/form | Academic theses. |
| Genre/form | Thèses et écrits académiques. |
