Some effects of estrogen and estrogen with progesterone on respiratory gas exchange in castrated female albino rats / by Willard Thomas Whitehurst, Jr.
| Author/creator | Whitehurst, Willard Thomas author. |
| Other author | Simpson, Everett C., degree supervisor. |
| Other author | East Carolina University. Department of Biology. |
| Format | Theses and dissertations |
| Production | 1965. |
| Description | 51 leaves : illustrations ; 29 cm |
| Supplemental Content | Access via ScholarShip |
| Subjects |
| Summary | The primary objective of this work was an attempt to establish and correlate changes in the metabolic rate with the four stages of the reproductive cycle in female albino rats as measured by O₂ uptake and CO₂ production, and to duplicate the changes found in the control condition by the addition of gonadal hormones to castrate female rats. A total of twenty replications were made in each of the four stages of the estrus cycle. That is, twenty measurements of the respiratory gases were made in dlestrus, proestrus, estrus, and metestrus, which gave a total of 60 measurements. All of the above measurements were made on intact animals. Following this the animals were castrated and seperated into two groups. One group was treated with 2.5 mg of estrogen which was injected subcutaneously. The injections were given on two consecutive days so that the animal received a total of 5 mg of estrogen. The other group was similarly except that they received two 2.5 mg dosages of progesterone in addition to the estrogen. The respiratory gases were measured daily in the treated groups and vaginal lavages were taken also in order to determine the stage of the reproductive cycle which the animals were exhibiting. All of the measurements made were corrected to standard temperature and pressure and reported in ml/g of body weight/hr. The results were subjected to statistical analysis and plotted graphically. It was noted that only one half of the estrogen treated animals showed proestrus whereas the progesterone-estrogen treated animals showed proestrus in 80% of the Instances. Statistical significance was not found for either O₂ consumption or CO₂ production in the comparison between the control and the two treated groups in corresponding stages of the reproductive cycle. This means that there was very little variation from the control condition by the treated animals. It was apparent that the progesterone-estrogen treated animals did approach the control conditions more consistently than did the estrogen treated animals |
| General note | Submitted to the faculty of the Department of Biology. |
| General note | Advisor: Everett C. Simpson |
| Dissertation note | M.A. East Carolina College 1965 |
| Bibliography note | Includes bibliographical references (leaves 49-51). |
| Genre/form | Academic theses. |
| Genre/form | Academic theses. |
| Genre/form | Thèses et écrits académiques. |
Availability
| Library | Location | Call Number | Status | Item Actions |
|---|---|---|---|---|
| Joyner | University Archives | ASK AT SPECIAL COLLECTIONS DESK | ✔ Available | Request Material |
| Electronic Resources | ✔ Available |