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049 a| EREE;

050 4 a| QL872b| .M36x 1965;

100 1 a| Mannino, Joseph Robert,d| 1941-e| author.?| UNAUTHORIZED;

245 10 a| Unidirectional sodium flux in the duodenum, jejunum and ileum of normal and desoxycorticosterone acetate-treated male, laboratory rats /c| by J. Robert Mannino.;

264 0 c| 1965.;

300 a| 48 leaves :b| illustrations ;c| 28 cm;

336 a| textb| txt2| rdacontent;

337 a| unmediatedb| n2| rdamedia;

338 a| volumeb| nc2| rdacarrier;

502 b| M.A.c| East Carolina Colleged| 1965;

500 a| Submitted to the faculty of the Department of Biology.;

500 a| Advisor: Everett C. Simpson;

520 3 a| The purpose of this study Is to Investigate the relationship between deoxycorticosterone acetate (DOCA) and sodium retention in the small Intestine. A method was devised by which the effect of DOCA on the sodium flux In the small intestine could be measured. Radioactive sodium (sodlum-22) was used as a tracer to discern sodium transfer subsequent to DOCA administration, while a colorimetric analysis was used to ascertain total sodium. Utilizing these two techniques together with Isolated, In vivo Intestinal sections, a two fold study was made 1} to determine the effects of DOGA on the sodium flux and; 2} to determine any possible regional differential in sodium transfer in the small Intestine. It was found ttiat a definite absorption gradient of sodium was noted In the control condition with the greatest amount of absorption in jejunum. DOCA was found to significantly decrease the unidirectional Influx of sodium In the duodenum and jejunum, while a similar effect was not demonstrated in the Ileum. A possible mechanism, similar to the glucose-Insulin transport theory, Is postulated and discussed for the action of DOCA and the I active transport of sodium.;

504 a| Includes bibliographical references (leaves 47-48).;

650 0 a| Excretory organs.=| ^A285721;

650 0 a| Corticosterone.=| ^A13428;

650 0 a| Sodiumx| Metabolism.=| ^A11902;

650 0 a| Rats as laboratory animals.=| ^A10876;

650 2 a| Corticosterone.0| (DNLM)D003345=| ^A1486611;

655 2 a| Academic Dissertation.0| (DNLM)D019478?| UNAUTHORIZED;

650 7 a| Corticosterone.2| fast0| (OCoLC)fst00880406;

650 7 a| Excretory organs.2| fast0| (OCoLC)fst00917745;

650 7 a| Sodiumx| Metabolism.2| fast0| (OCoLC)fst01124032;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

700 1 a| Simpson, Everett C.,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 41 z| Access via ScholarShipu| http://hdl.handle.net/10342/11234;

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Unidirectional sodium flux in the duodenum, jejunum and ileum of normal and desoxycorticosterone acetate-treated male, laboratory rats / by J. Robert Mannino.

Author/creator	Mannino, Joseph Robert, 1941- author.
Other author	Simpson, Everett C., degree supervisor.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Production	1965.
Description	48 leaves : illustrations ; 28 cm
Supplemental Content	Access via ScholarShip
Subjects	Excretory organs. Corticosterone. Sodium--Metabolism. Rats as laboratory animals. Corticosterone.

Summary	The purpose of this study Is to Investigate the relationship between deoxycorticosterone acetate (DOCA) and sodium retention in the small Intestine. A method was devised by which the effect of DOCA on the sodium flux In the small intestine could be measured. Radioactive sodium (sodlum-22) was used as a tracer to discern sodium transfer subsequent to DOCA administration, while a colorimetric analysis was used to ascertain total sodium. Utilizing these two techniques together with Isolated, In vivo Intestinal sections, a two fold study was made 1} to determine the effects of DOGA on the sodium flux and; 2} to determine any possible regional differential in sodium transfer in the small Intestine. It was found ttiat a definite absorption gradient of sodium was noted In the control condition with the greatest amount of absorption in jejunum. DOCA was found to significantly decrease the unidirectional Influx of sodium In the duodenum and jejunum, while a similar effect was not demonstrated in the Ileum. A possible mechanism, similar to the glucose-Insulin transport theory, Is postulated and discussed for the action of DOCA and the I active transport of sodium.
General note	Submitted to the faculty of the Department of Biology.
General note	Advisor: Everett C. Simpson
Dissertation note	M.A. East Carolina College 1965
Bibliography note	Includes bibliographical references (leaves 47-48).
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

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Unidirectional sodium flux in the duodenum, jejunum and ileum of normal and desoxycorticosterone acetate-treated male, laboratory rats / by J. Robert Mannino.

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