G protein coupled receptors modeling, activation, interactions and virtual screening / edited by P. Michael Conn, Divisions of Reproductive Sciences and Neuroscience (ONPRC) & Departments of Pharmacology and Physicology Cell and Developmental Biology, and Obstetrics and Gynecology (OHSU), Beaverton, OR, USA.

Other author Conn, P. Michael.
Format Electronic
EditionFirst edition.
Publication InfoAmsterdam ; Boston : Elsevier/AP, 2013.
Descriptionlvi, 472 pages, 12 unnumbered pages of plates : illustrations (some color) ; 24 cm.
Supplemental ContentFull text available from ScienceDirect Enzymology Book Series
Supplemental ContentFull text available from Methods in Enzymology
Subjects

SeriesMethods in enzymology, 0076-6879 ; volume 522
Methods in enzymology ; v. 522. ^A497553
Contents The protein local optimization program and G-protein-coupled receptors : loop restoration and applications to homology modeling / Dahlia A. Goldfeld and Richard A. Friesner -- Modeling active GPCR conformations / Bruck Taddese, Lisa M. Simpson, Ian D. Wall, Frank E. Blaney, and Christopher A. Reynolds -- Molecular modeling of adenosine receptors / Adriano Martinelli and Gabriella Ortore -- Predicting G-protein-coupled receptors families using different physiochemical properties and pseudo amino acid composition / Zia-ur Rehman, Muhammad Tayyeb Mirza, Asifullah Khan, and Henri Xhaard -- Computational design and experimental characterization of GPCR segment models / Abby L. Parrill -- G-protein-coupled receptor interaction with small GTPases / Chunmin Dong and Guangyu Wu -- Quantification of receptor tyrosine kinase activiation and transactivation by G-protein-coupled receptors using spatial intensity distribution analysis (SplDA) / Annie Barbeau, Antoine G. Godin, Jody L. Swift, Yves De Koninck, Paul W. Wiseman, and Jean-Martin Beaulieu -- NMR modeling for detection of small molecule binding to RGS4 / Andrew J. Storaska and Richard R. Neubig --Group II activators of G-protein signaling : monitoring the interaction of G[alpha] with the G-protein regulatory motif in the intact cell / Sukru Sadik Oner, Joe B. Blumer, and Stephen M. Lanier -- Homogenous time-resolved fluorescence assay to probe folded G protein-coupled receptors / Adam M. Knepp, Thomas P. Sakmar, and Thomas Huber -- cAMP biosensors applied in molecular pharmacological studies of G protein-coupled receptors / Jesper Mosolff Mathiesen, Line Vedel, and Hans Bräuner-Osborne -- Rhodospin-lipid intereactions studied by NMR / Olivier Soubias and Klaus Gawrisch -- Biasing the parathyroid hormone receptor : relating in vitro ligand efficacy to in vivo biological activity / Kathryn M. Appleton, Mi-Hye Lee, Christian Alele, Christine Alele, Deirdre K. Luttrell, Yuri K. Peterson, Thomas A. Morinelli, and Louis M. Luttrell -- Application of Monte Carlo-based receptor ensemble docking to virtual screening for GPCR ligands / Santiago Vilar and Stefano Costanzi -- From heptahelical bundle to hits from the haystack : structure-based virtual screening for GPCR ligands / Albert J. Kooistra, Luc Roumen, Rob Leurs, Iwan J.P. de Esch, and Chris de Graaf -- Kinetics and dynamics in the G protein-coupled receptor signaling cascade / Jean-Pierre Vilardaga, Guillermo Romero, Timothy N. Feinstein, and Vanessa L. Wehbi -- Magic angle spinning nuclear magnetic resonance spectroscopy fo G protein-coupled receptors / Joseph Goncalves, Markus Eilers, Kieron South, Chikwado A. Opefi, Philippe Laissue, Philip J. Reeves, and Steven O. Smith -- Posttranslation modification of G protein-coupled receptor in relationship to biased agonism / Hui Zheng, Horace H. Loh, and Ping-Yee Law -- Protein S-nitrosylation measurement / Yu Qin, Anindya Dey, and Yehia Daaka.
Bibliography noteIncludes bibliographical references and indexes.
Access restrictionAvailable only to authorized users.
Technical detailsMode of access: World Wide Web
Genre/formElectronic books.
LCCN 2013372351
ISBN9780124078659 (hbk)
ISBN0124078656 (hbk)

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