Analysis of aggregates and particles in protein pharmaceuticals / edited by Hanns-Christian Mahler, Wim Jiskoot.

Other author Mahler, Hanns-Christian.
Other author Jiskoot, Wim.
Format Electronic
Publication InfoHoboken, N.J. : John Wiley & Sons, Inc.,
Descriptionxvi, 443 p., [12] p. of plates : ill. (some col.) ; 25 cm.
Supplemental ContentFull text available from Ebook Central - Academic Complete
Subjects
Pharmaceutical Preparations--analysis.
Chemistry Techniques, Analytical--methods.
Proteins--pharmacokinetics.

Contents The critical need for robust assays for quantitation and characterization of aggregates of therapeutic proteins -- Separation based analytical methods for measuring protein aggregation -- Laser light scattering-based techniques used for the characterization of protein therapeutics -- Online detection methods and emerging techniques for soluble aggregates in protein pharmaceuticals -- Analytical methods to measure sub-visible particulates -- Detection of visible particles in parenteral products -- Characterization of aggregates and particles using emerging techniques -- Ultraviolet absorption spectroscopy -- Fluorescence spectroscopy to characterize protein aggregates and particles -- Infrared spectroscopy to characterize protein aggregates -- Raman microscopy for characterization of particles -- Microscopic methods for particle characterization in protein pharmaceuticals -- Comparison of methods for soluble aggregate detection and size characterization -- Protein purification and its relation to protein aggregation and particles -- Formulation development and its relation to protein aggregation and particles.
Bibliography noteIncludes bibliographical references.
Access restrictionAvailable only to authorized users.
Technical detailsMode of access: World Wide Web
Genre/formElectronic books.
LCCN 2011026192
ISBN9780470497180 (cloth)
ISBN0470497181 (cloth)

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