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001 ocn919448351;

003 OCoLC;

005 20160202100010.0;

006 m o d ;

007 cr bn|||||||||;

008 150831s2015 ncua ob 000 0 eng d;

035 a| (Sirsi) o919448351;

035 a| (OCoLC)919448351;

049 a| EREE;

090 a| RA1224.45;

100 1 a| Edwards, Matthew K.,e| author.?| UNAUTHORIZED;

245 10 a| Species and stage specific developmental toxicity of endosulfan exposure in Hyla cinerea and Ranitomeya imitator /c| by Matthew K. Edwards.;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2015.;

300 a| 69 pages :b| illustrations (some color);

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text fileb| PDFc| 2.33Mb2| rda;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| M.S.c| East Carolina Universityd| 2015.;

500 a| Presented to the faculty of the Department of Biology.;

500 a| Advisor: Krista McCoy.;

500 a| Title from PDF t.p. (viewed September 30, 2015).;

520 3 a| During ontogeny, organisms pass through critical periods of heightened vulnerability to disruptive exogenous agents. In organisms with complex life cycles, these developmental windows result in variable susceptibility across life stages. Consequently, developmental anomalies that occur during early life may carry-over to affect later stages and ultimately individual fitness. This study investigated stage specific and carry-over effects on anuran growth and development following low dose exposure to the insecticide endosulfan. For this purpose, Hyla cinerea and Ranitomeya imitator embryos and larvae were continuously exposed, either individually or in combination, to a gradient of environmentally relevant concentrations of endosulfan (0, 0.1, 1, 10, 100, and 1,000 ng/L) until completion of metamorphosis. Though effects on mortality, deformity, and timing to and condition at multiple developmental points were not significant, observed abnormalities implicated endosulfan exposure. Embryonic R. imitator exposed to endosulfan experienced greater mortality and deformity than did those exposed as larvae, though H. cinerea life stages did not exhibit large differences with either endpoint. These findings indicate that traditional indicators of developmental toxicity may not provide an adequate characterization of pesticide hazards across species and life stages.;

504 a| Includes bibliographical references.;

650 0 a| Developmental toxicology.=| ^A286571;

650 0 a| Acaricides.=| ^A825036;

650 0 a| Endosulfan.=| ^A1122631;

650 0 a| Organochlorine compounds.=| ^A72366;

650 0 a| Insecticidesx| Toxicology.=| ^A8854;

650 0 a| Green treefrog.=| ^A1096758;

650 0 a| Rana.=| ^A70155;

653 a| Toxicology;

653 a| Developmental biology;

653 a| Amphibian;

653 a| Embryos;

653 a| Metamorphosis;

653 a| Tadpoles;

700 1 a| McCoy, Krista,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/5005;

949 o| jgml;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 3808148;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 3808148-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 8/31/2015x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 3808148-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 8/31/2015x| ETDz| HERESOURCE;

Species and stage specific developmental toxicity of endosulfan exposure in Hyla cinerea and Ranitomeya imitator / by Matthew K. Edwards.

Author/creator	Edwards, Matthew K. author.
Other author	McCoy, Krista, degree supervisor.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2015.
Description	69 pages : illustrations (some color)
Supplemental Content	Access via ScholarShip
Subjects	Developmental toxicology. Acaricides. Endosulfan. Organochlorine compounds. Insecticides--Toxicology. Green treefrog. Rana.

Summary	During ontogeny, organisms pass through critical periods of heightened vulnerability to disruptive exogenous agents. In organisms with complex life cycles, these developmental windows result in variable susceptibility across life stages. Consequently, developmental anomalies that occur during early life may carry-over to affect later stages and ultimately individual fitness. This study investigated stage specific and carry-over effects on anuran growth and development following low dose exposure to the insecticide endosulfan. For this purpose, Hyla cinerea and Ranitomeya imitator embryos and larvae were continuously exposed, either individually or in combination, to a gradient of environmentally relevant concentrations of endosulfan (0, 0.1, 1, 10, 100, and 1,000 ng/L) until completion of metamorphosis. Though effects on mortality, deformity, and timing to and condition at multiple developmental points were not significant, observed abnormalities implicated endosulfan exposure. Embryonic R. imitator exposed to endosulfan experienced greater mortality and deformity than did those exposed as larvae, though H. cinerea life stages did not exhibit large differences with either endpoint. These findings indicate that traditional indicators of developmental toxicity may not provide an adequate characterization of pesticide hazards across species and life stages.
General note	Presented to the faculty of the Department of Biology.
General note	Advisor: Krista McCoy.
General note	Title from PDF t.p. (viewed September 30, 2015).
Dissertation note	M.S. East Carolina University 2015.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

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Species and stage specific developmental toxicity of endosulfan exposure in Hyla cinerea and Ranitomeya imitator / by Matthew K. Edwards.

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