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003 OCoLC;

005 20160202100009.0;

006 m o d ;

007 cr bn|||||||||;

008 150831s2015 ncua ob 000 0 eng d;

035 a| (Sirsi) o919448194;

035 a| (OCoLC)919448194;

049 a| EREE;

090 a| QP572.T4;

100 1 a| Blake, Bevin Ellen,e| author.?| UNAUTHORIZED;

245 10 a| Exposure to elevated prenatal testosterone metabolites induce autism-like behavior in rats :b| evidence for the extreme male brain and implications for human health /c| by Bevin Ellen Blake.;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2015.;

300 a| 147 pages :b| illustrations (some color);

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text fileb| PDFc| 21.85Mb2| rda;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| M.S.c| East Carolina Universityd| 2015.;

500 a| Presented to the faculty of the Department of Biology.;

500 a| Advisor: Krista McCoy.;

500 a| Title from PDF t.p. (viewed September 21, 2015).;

520 3 a| Neurodevelopmental disorders such as autism spectrum disorder (ASD) originate during early brain development and are the result of complex interactions between genetic and environmental factors. Disruptions in the prenatal hormone environment have been associated with increasing the risk for autism. The extreme male brain theory of autism states that ASD results from abnormally high levels of prenatal testosterone that result in a hypermasculinized (autistic) brain. Prenatal androgen signaling programs behavior through the actions of androgen or estrogen receptors throughout diverse brain regions. The balance of this sex hormone signaling is critical for neuronal organization, and disruptions in normal prenatal hormone levels lead to aberrations in critical behaviors such as juvenile social play, which is important for normal cognitive and social development. This research demonstrates that exposure to excess testosterone metabolites during development induces autism-like behaviors in the rat, including reduced social interactions, abnormal stress response, and enhanced spatial ability, which support the extreme male brain theory.;

504 a| Includes bibliographical references.;

650 0 a| Testosterone.=| ^A47968;

650 0 a| Hormones.=| ^A269;

650 0 a| Autism spectrum disorders.=| ^A916967;

650 0 a| Prenatal influences.=| ^A6007;

653 a| Endocrinology;

653 a| Behavioral sciences;

653 a| Autism;

653 a| Extreme male brain;

653 a| Prenatal hormones;

653 a| Testosterone metabolites;

700 1 a| McCoy, Krista,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/5017;

949 o| jgml;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 3808131;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 3808131-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 8/31/2015x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 3808131-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 8/31/2015x| ETDz| HERESOURCE;

Exposure to elevated prenatal testosterone metabolites induce autism-like behavior in rats : evidence for the extreme male brain and implications for human health / by Bevin Ellen Blake.

Author/creator	Blake, Bevin Ellen author.
Other author	McCoy, Krista, degree supervisor.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2015.
Description	147 pages : illustrations (some color)
Supplemental Content	Access via ScholarShip
Subjects	Testosterone. Hormones. Autism spectrum disorders. Prenatal influences.

Summary	Neurodevelopmental disorders such as autism spectrum disorder (ASD) originate during early brain development and are the result of complex interactions between genetic and environmental factors. Disruptions in the prenatal hormone environment have been associated with increasing the risk for autism. The extreme male brain theory of autism states that ASD results from abnormally high levels of prenatal testosterone that result in a hypermasculinized (autistic) brain. Prenatal androgen signaling programs behavior through the actions of androgen or estrogen receptors throughout diverse brain regions. The balance of this sex hormone signaling is critical for neuronal organization, and disruptions in normal prenatal hormone levels lead to aberrations in critical behaviors such as juvenile social play, which is important for normal cognitive and social development. This research demonstrates that exposure to excess testosterone metabolites during development induces autism-like behaviors in the rat, including reduced social interactions, abnormal stress response, and enhanced spatial ability, which support the extreme male brain theory.
General note	Presented to the faculty of the Department of Biology.
General note	Advisor: Krista McCoy.
General note	Title from PDF t.p. (viewed September 21, 2015).
Dissertation note	M.S. East Carolina University 2015.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

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Exposure to elevated prenatal testosterone metabolites induce autism-like behavior in rats : evidence for the extreme male brain and implications for human health / by Bevin Ellen Blake.

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