Regulation of insulin receptor function in skeletal muscle in response to diet, aging and exercise / by Judy J. Boyd.
| Author/creator | Boyd, Judy J. author. |
| Other author | Dohm, G. Lynis, degree supervisor. |
| Other author | East Carolina University. Department of Biology. |
| Format | Theses and dissertations |
| Production | 1990. |
| Description | v, 83 leaves : illustrations ; 28 cm |
| Supplemental Content | Access via ScholarShip |
| Subjects |
| Summary | The insulin resistance of skeletal muscle may be caused by a decrease in insulin binding, decrease in the tyrosine kinase activity of the insulin receptor, or intracellular processing of the insulin receptor. In the present study, rats are rendered insulin resistant with high fat-sucrose (HFS) feeding. Insulin binding and tyrosine kinase activity in receptors isolated from liver were significantly decreased in animals fed a HFS diet. In contrast, there is no effect of (HFS) feeding on insulin binding or tyrosine kinase activity in receptors isolated from skeletal muscle. Insulin resistance also develops during the aging process. However, insulin binding and tyrosine kinase activity of receptors isolated from skeletal muscle appear relatively unaffected by aging. In contrast to diet and aging, exercise training increases insulin sensitivity. However, old exercise trained rats exhibited similar insulin binding and kinase activity when compared to old untrained animals. In summary insulin binding and kinase activity of receptors isolated from skeletal muscle appear relatively unaffected by dietary induced insulin resistance, aging induced insulin resistance and exercise training of old animals. In considering the role of the internalized hormone-receptor complex, it was evident from preliminary experiments that the complex undergoes internalization and processing similar to what has been shown in hepatocytes and adipocytes. |
| General note | Submitted to the faculty of the Department of Biology. |
| General note | Advisor: G. Lynis Dohm |
| Dissertation note | M.S. East Carolina University 1990 |
| Bibliography note | Includes bibliographical references (leaves 80-83). |
| Genre/form | Academic theses. |
| Genre/form | Academic theses. |
| Genre/form | Thèses et écrits académiques. |
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|---|---|---|---|---|
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