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001 ocn824991947;

003 OCoLC;

005 20141212050939.0;

006 m o d ;

007 cr bn|||||||||;

008 130123s2012 ncua ob 000 0 eng d;

035 a| (Sirsi) o824991947;

035 a| (OCoLC)824991947;

040 a| EREc| EREd| EREd| UtOrBLW;

049 a| EREE;

100 1 a| Gaines, Gary Christopher.?| UNAUTHORIZED;

245 10 a| Generators of mammalian vestibular surface responses to head motion /c| by Gary Christopher Gaines, II.;

260 a| [Greenville, N.C.] :b| East Carolina University,c| 2012.;

300 a| 144 pages :b| digital, PDF file.;

336 a| text2| rdacontent;

337 a| computer2| rdamedia;

338 a| online resource2| rdacarrier;

490 1 a| ECU College of Allied Health Sciences thesis;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| Ph.D.c| East Carolina Universityd| 2012.;

500 a| Presented to the faculty of the Department of Communication Sciences and Disorders.;

500 a| Advisor: Timothy A. Jones.;

500 a| Title from PDF t.p. (viewed January 23, 2013).;

520 3 a| The linear vestibular sensory evoked potential (VsEP) is thought to be the compound electrical response of peripheral macular neurons and central neural relays, and as such used to directly assess macular function. The VsEP is used in animal research to study, among other things, the genetic basis of deafness and balance disorders. Although the neural generators of the linear VsEP have been described in the bird, the precise central neural generators have not been documented for the mouse model. Because the mouse is such a valuable model in vestibular research, it is important to clearly identify the peripheral and central generators of VsEPs in mice. In order to complete such studies, various preface studies were completed to insure the accuracy of measurement with the generator studies. These studies included evaluation of VsEP response morphology with change in brain temperature; evaluation of drug on the VsEP response (i.e., Ketorolac); and the evaluation of stimulus duration on the VsEP response. During generator studies, VsEPs before and after strategic surgical manipulations of vestibular pathways were recorded. This included isolation of the eighth nerve from central relays and destruction of central candidate neural generators. The extent of lesions was characterized histologically and changes in response components were documented. Response components critically dependent on particular peripheral and central structures were identified. These studies have increased the understanding of the neural generators of the VsEP, and in turn, enhanced the ability to assess peripheral and central vestibular function and detect vestibular disease.;

504 a| Includes bibliographical references.;

650 2 a| Vestibular Evoked Myogenic Potentials.=| ^A1134961;

650 2 a| Ketorolac.=| ^A1134928;

650 2 a| Mice.=| ^A921375;

650 2 a| Investigative Techniques.=| ^A933244;

650 2 a| Vestibule, Labyrinthx| physiology.=| ^A935799;

650 2 a| Reflex, Vestibulo-Ocular.=| ^A952067;

650 2 a| Vestibular Nucleix| physiology.=| ^A1134907;

650 2 a| Evoked Potentials.=| ^A919750;

650 2 a| Auditory Pathways.=| ^A918661;

650 2 a| Auditory Pathwaysx| physiology.=| ^A921915;

650 2 a| Models, Animal.=| ^A935493;

653 a| Audiology;

653 a| Neurosciences;

700 1 a| Jones, Timothy A.q| (Timothy Arthur),d| 1948-=| ^A1061507;

710 2 a| East Carolina University.b| Department of Communication Sciences and Disorders.?| UNAUTHORIZED;

830 0 a| ECU College of Allied Health Sciences thesis.?| UNAUTHORIZED;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/4067;

949 a| Click on web addressw| ASISh| JOYNER101;

949 a| Click on web addressw| ASISh| HSL111;

994 a| C0b| ERE;

096 a| WV 272;

596 a| 1 4;

998 a| 3257343;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 3257343-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 1/23/2013x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 3257343-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 1/23/2013x| ETDz| HERESOURCE;

Generators of mammalian vestibular surface responses to head motion / by Gary Christopher Gaines, II.

Author/creator	Gaines, Gary Christopher
Other author	Jones, Timothy A. (Timothy Arthur), 1948-
Other author	East Carolina University. Department of Communication Sciences and Disorders.
Format	Theses and dissertations
Publication Info	[Greenville, N.C.] : East Carolina University, 2012.
Description	144 pages : digital, PDF file.
Supplemental Content	Access via ScholarShip
Subjects	Vestibular Evoked Myogenic Potentials. Ketorolac. Mice. Investigative Techniques. Vestibule, Labyrinth--physiology. Reflex, Vestibulo-Ocular. Vestibular Nuclei--physiology. Evoked Potentials. Auditory Pathways. Auditory Pathways--physiology. Models, Animal.

Series	ECU College of Allied Health Sciences thesis ECU College of Allied Health Sciences thesis. UNAUTHORIZED
Summary	The linear vestibular sensory evoked potential (VsEP) is thought to be the compound electrical response of peripheral macular neurons and central neural relays, and as such used to directly assess macular function. The VsEP is used in animal research to study, among other things, the genetic basis of deafness and balance disorders. Although the neural generators of the linear VsEP have been described in the bird, the precise central neural generators have not been documented for the mouse model. Because the mouse is such a valuable model in vestibular research, it is important to clearly identify the peripheral and central generators of VsEPs in mice. In order to complete such studies, various preface studies were completed to insure the accuracy of measurement with the generator studies. These studies included evaluation of VsEP response morphology with change in brain temperature; evaluation of drug on the VsEP response (i.e., Ketorolac); and the evaluation of stimulus duration on the VsEP response. During generator studies, VsEPs before and after strategic surgical manipulations of vestibular pathways were recorded. This included isolation of the eighth nerve from central relays and destruction of central candidate neural generators. The extent of lesions was characterized histologically and changes in response components were documented. Response components critically dependent on particular peripheral and central structures were identified. These studies have increased the understanding of the neural generators of the VsEP, and in turn, enhanced the ability to assess peripheral and central vestibular function and detect vestibular disease.
General note	Presented to the faculty of the Department of Communication Sciences and Disorders.
General note	Advisor: Timothy A. Jones.
General note	Title from PDF t.p. (viewed January 23, 2013).
Dissertation note	Ph.D. East Carolina University 2012.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

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Generators of mammalian vestibular surface responses to head motion / by Gary Christopher Gaines, II.

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