Solvent and solubility effects on quinone ratios / by Brian Duffy.
| Author/creator | Duffy, Brian |
| Other author | Love, Brian Ernest. |
| Other author | East Carolina University. Department of Chemistry. |
| Format | Theses and dissertations |
| Publication Info | [Greenville, N.C.] : East Carolina University, 2012. |
| Description | 67 pages : illustrations, digital, PDF file |
| Supplemental Content | Access via ScholarShip |
| Subjects |
| Summary | Monoquinones and diquinones are a biologically and chemically important class of compounds that can be found in numerous natural products such as: thymoquinone, oosporein, coenzyme Q, embelin and the respective dimer, biembelin. These 1, 4-benzoquinone derivatives exhibit prominent pharmacological applications such as antibiotic, anti-tumor, anti-malarial, anti-coagulant, and anti-convulsant activity. Though quinones can be prepared by a variety of processes, they are most commonly synthesized through the treatment of hydroquinone dimethyl ethers with ceric ammonium nitrate (CAN). However, this can lead to an unpredictable mixture of monoquinone and diquinone as the products. This project has investigated the effect of solvent and substrate water solubility on monoquinone / diquinone product ratios with the aim of being able to consistently and predictably favor one (monoquinone or diquinone) over the other. |
| General note | Presented to the faculty of the Department of Chemistry. |
| General note | Advisor: Brian Love. |
| General note | Title from PDF t.p. (viewed Sept. 25, 2012). |
| Dissertation note | M.S. East Carolina University 2012. |
| Bibliography note | Includes bibliographical references. |
| Technical details | System requirements: Adobe Reader. |
| Technical details | Mode of access: World Wide Web. |
Availability
| Library | Location | Call Number | Status | Item Actions |
|---|---|---|---|---|
| Electronic Resources | Access Content Online | ✔ Available |