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001 ocn733841528;

003 OCoLC;

005 20151103143338.0;

006 m d ;

007 cr bn|||||||||;

008 110630s2010 ncua ob 000 0 eng d;

035 a| (Sirsi) o733841528;

035 a| (OCoLC)733841528;

040 a| EREc| EREd| EREd| UtOrBLW;

049 a| EREE;

090 a| QP572.P74;

100 1 a| Nguyen, Nhu.=| ^A1044997;

245 10 a| Prolactin function in zebrafish development /c| by Nhu Nguyen.;

260 a| [Greenville, N.C.] :b| East Carolina University,c| 2010.;

300 a| 240 pages :b| illustrations (some color), digital, PDF file;

336 a| text2| rdacontent;

337 a| computer2| rdamedia;

338 a| online resource2| rdacarrier;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| Ph.D.c| East Carolina Universityd| 2010.;

500 a| Presented to the faculty of the Department of Biology.;

500 a| Advisor: Terry West.;

500 a| Title from PDF t.p. (viewed Aug. 3, 2011).;

520 3 a| Extensive studies have implicated a myriad of functional roles for prolactin (PRL) and prolactin receptor (PRLR) across a variety of adult vertebrate species. However, much less is known about the physiological role(s) of PRL during embryonic/fetal development. Previously, we demonstrated that in vivo knockdown of PRL produced embryos with multiple morphological abnormalities. In this study, we explored the function of the PRLR family during embryogenesis and established the zebrafish as a useful model organism to examine embryonic functions of PRL. The combined results (1) define a role for PRL during early embryonic development, (2) provide plausible explanation(s) for the observed phenotypes in PRL-knockdown embryos, and (3) provide a foundation for the direction of future research using zebrafish as a model for studying physiological roles and molecular mechanisms of the PRL superfamily in vertebrates.;

504 a| Includes bibliographical references.;

650 0 a| Prolactinx| Research.=| ^A6685;

650 0 a| Zebra danios as laboratory animals.=| ^A1012134;

650 0 a| Zebra daniox| Embryology.=| ^A584582;

653 a| Endocrinology;

653 a| Developmental Biology;

653 a| Molecular Biology;

700 1 a| West, Terry L.q| (Terry Lynn),d| 1946-=| ^A1268118;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/3573;

949 o| jgml;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 2507481;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 2507481-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 6/30/2011x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 2507481-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 6/30/2011x| ETDz| HERESOURCE;

Prolactin function in zebrafish development / by Nhu Nguyen.

Author/creator	Nguyen, Nhu
Other author	West, Terry L. (Terry Lynn), 1946-
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Publication Info	[Greenville, N.C.] : East Carolina University, 2010.
Description	240 pages : illustrations (some color), digital, PDF file
Supplemental Content	Access via ScholarShip
Subjects	Prolactin--Research. Zebra danios as laboratory animals. Zebra danio--Embryology.

Summary	Extensive studies have implicated a myriad of functional roles for prolactin (PRL) and prolactin receptor (PRLR) across a variety of adult vertebrate species. However, much less is known about the physiological role(s) of PRL during embryonic/fetal development. Previously, we demonstrated that in vivo knockdown of PRL produced embryos with multiple morphological abnormalities. In this study, we explored the function of the PRLR family during embryogenesis and established the zebrafish as a useful model organism to examine embryonic functions of PRL. The combined results (1) define a role for PRL during early embryonic development, (2) provide plausible explanation(s) for the observed phenotypes in PRL-knockdown embryos, and (3) provide a foundation for the direction of future research using zebrafish as a model for studying physiological roles and molecular mechanisms of the PRL superfamily in vertebrates.
General note	Presented to the faculty of the Department of Biology.
General note	Advisor: Terry West.
General note	Title from PDF t.p. (viewed Aug. 3, 2011).
Dissertation note	Ph.D. East Carolina University 2010.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

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Prolactin function in zebrafish development / by Nhu Nguyen.

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