Tools

LEADER 05090nam a2200517Ia 4500

001 ocn703659709;

003 OCoLC;

005 20141212055349.0;

006 m d ;

007 cr bn|||||||||;

008 110224s2010 ncua sb 000 0 eng d;

035 a| (Sirsi) o703659709;

035 a| (OCoLC)703659709;

040 a| NEHc| NEHd| NEHd| UtOrBLW;

049 a| NEHH;

100 1 a| Cook, Pamela Renee.?| UNAUTHORIZED;

245 10 a| Molecular characterization of the activation domain of the HTLV-1 HBZ protein and its interaction with the KIX domain of the cellular transcriptional coactivators p300 and CBP /c| by Pamela Renee Cook.;

260 a| [Greenville, N.C.] :b| East Carolina University,c| 2010.;

300 a| 178 pages :b| illustrations (some color), digital, PDF file.;

336 a| text2| rdacontent;

337 a| computer2| rdamedia;

338 a| online resource2| rdacarrier;

490 1 a| ECU Brody School of Medicine thesis;

500 a| Presented to the faculty of the Department of Interdisciplinary Biological Sciences.;

500 a| Advisor: Isabelle Lemasson.;

500 a| Title from PDF t.p. (viewed February 21, 2011).;

502 b| Ph.D.c| East Carolina Universityd| 2010.;

504 a| Includes bibliographical references.;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

520 3 a| The complex retrovirus human T-cell leukemia virus type I (HTLV-1) is the causative agent of adult T-cell leukemia (ATL). Deregulation of cellular transcription is thought to be a key event in virally-mediated T-cell transformation. The HTLV-1 basic leucine zipper factor (HBZ) originates from the 3' long terminal repeat (LTR) and is transcribed from the sense DNA strand relative to other viral genes. HBZ is the only viral gene known to be consistently expressed in ATL cells. HBZ is able to repress HTLV-1 transcription, in part, by binding to the homologous cellular coactivators p300 and CREB-binding protein (CBP). HBZ binds the kinase-inducible interaction (KIX) domain of p300/CBP via two ΦΤΤΦΦ· κμϟζεπ ζλ ϟϝδ αϐϟζσαϟζμλ γμκαζλ με ϜΒΦ ϜΒΦΑΓ Ζλ ϟϝζπ πϟργυ ζϟ ςαπ γδϟδοκζλδγ ϟϝαϟ ϜΒΦΑΓ βζλγπ ςζϟϝ ϝζϛϝ αεεζλζϟυ ϟμ ϟϝδ ΘΖΤ γμκαζλ με ν”««ΒΝ ςζϟϝ αλ ανναοδλϟ δξρζιζβοζρκ γζππμϐζαϟζμλ ϐμλπϟαλϟ Θγ με ”“ ± «͵ λΚ Ϟϝδ ΘΖΤ γμκαζλ ϐμλϟαζλπ ϟςμ βζλγζλϛ προεαϐδπ ϟϝαϟ αοδ γζεεδοδλϟζαιιυ ϟαοϛδϟδγ βυ σαοζμρπ ϟοαλπϐοζνϟζμλαι οδϛριαϟμου νομϟδζλπ Μλδ προεαϐδ με ΘΖΤ ϐαλ βζλγ ϟϝδ αϐϟζσαϟζμλ γμκαζλ με ϟϝδ κζτδγ ιζλδαϛδ ιδρθδκζα ΚΙΙΑΓ νομϟδζλ αλγ ϟϝδ ϜϞΙΣ» ϟοαλπαϐϟζσαϟμο Ϟατ ακμλϛ μϟϝδοπ Ϟϝδ μϟϝδο προεαϐδ με ΘΖΤ ϐαλ ϐμλϟαϐϟ ϟϝδ ϐδιιριαο ϟοαλπϐοζνϟζμλ εαϐϟμοπ ϐΚυβ μο ϐυϐιζϐ ΑΚΝ ϐΑΚΝ οδπνμλπδ διδκδλϟ βζλγζλϛ νομϟδζλ ΟΔΒ ϜΒΦΑΓ ςαπ γδϟδοκζλδγ ϟμ βζλγ ϟϝδ ΚΙΙΑΓβζλγζλϛ προεαϐδ με ΘΖΤ αλγ ϟμ ϐμκνδϟδ ςζϟϝ ΚΙΙΑΓ Ϟατ αλγ ν͵” εμο ΘΖΤ βζλγζλϛ ϜΒΦΑΓ ςαπ αγγζϟζμλαιιυ εμρλγ ϟμ πζϛλζεζϐαλϟιυ δλϝαλϐδ ϟϝδ βζλγζλϛ με ϟϝδ αϐϟζσαϟζμλ γμκαζλ με ϐΚυβ ϐΚυβΑΓ αλγ ΟΔΒ ϟμ ΘΖΤ ϜΒΦ ςαπ αιπμ πϝμςλ ϟμ ζλϝζβζϟ ϟοαλπϐοζνϟζμλαι αϐϟζσαϟζμλ κδγζαϟδγ βυ ΚΙΙΑΓ αλγ δλϝαλϐδ αϐϟζσαϟζμλ κδγζαϟδγ βυ ϐΚυβΑΓ Ϟϝδπδ οδπριϟπ ζλγζϐαϟδ ϟϝαϟ ϜΒΦ ζπ αβιδ ϟμ αιϟδο ϛδλδ δτνοδππζμλ βυ ϐμκνδϟζλϛ ςζϟϝ μλδ ϛομρν με ϟοαλπϐοζνϟζμλ εαϐϟμοπ εμο μϐϐρναλϐυ με ΘΖΤ ςϝζιδ δλϝαλϐζλϛ ϟϝδ βζλγζλϛ με μϟϝδο εαϐϟμοπ ϟμ α γζεεδοδλϟ προεαϐδ μλ ΘΖΤ;

650 2 a| Human T-lymphotropic virus 1.=| ^A1037506;

650 2 a| Leukemiax| virology.=| ^A1037477;

653 a| Virology;

700 1 a| Lemasson, Isabelle.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Interdisciplinary Biological Sciences.?| UNAUTHORIZED;

830 0 a| ECU Brody School of Medicine thesis.=| ^A964744;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/3165;

949 a| Click on web addressw| ASISh| JOYNER101;

949 a| Click on web addressw| ASISh| HSL111;

994 a| C0b| NEH;

096 a| QW 168.5 R18;

596 a| 1 4;

998 a| 2407364;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 2407364-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 2/24/2011x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 2407364-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 2/24/2011x| ETDz| HERESOURCE;

Molecular characterization of the activation domain of the HTLV-1 HBZ protein and its interaction with the KIX domain of the cellular transcriptional coactivators p300 and CBP / by Pamela Renee Cook.

Author/creator	Cook, Pamela Renee
Other author	Lemasson, Isabelle.
Other author	East Carolina University. Department of Interdisciplinary Biological Sciences.
Format	Theses and dissertations
Publication Info	[Greenville, N.C.] : East Carolina University, 2010.
Description	178 pages : illustrations (some color), digital, PDF file.
Supplemental Content	Access via ScholarShip
Subjects	Human T-lymphotropic virus 1. Leukemia--virology.

Series	ECU Brody School of Medicine thesis ECU Brody School of Medicine thesis. ^A964744
Summary	The complex retrovirus human T-cell leukemia virus type I (HTLV-1) is the causative agent of adult T-cell leukemia (ATL). Deregulation of cellular transcription is thought to be a key event in virally-mediated T-cell transformation. The HTLV-1 basic leucine zipper factor (HBZ) originates from the 3' long terminal repeat (LTR) and is transcribed from the sense DNA strand relative to other viral genes. HBZ is the only viral gene known to be consistently expressed in ATL cells. HBZ is able to repress HTLV-1 transcription, in part, by binding to the homologous cellular coactivators p300 and CREB-binding protein (CBP). HBZ binds the kinase-inducible interaction (KIX) domain of p300/CBP via two ΦΤΤΦΦ· κμϟζεπ ζλ ϟϝδ αϐϟζσαϟζμλ γμκαζλ με ϜΒΦ ϜΒΦΑΓ Ζλ ϟϝζπ πϟργυ ζϟ ςαπ γδϟδοκζλδγ ϟϝαϟ ϜΒΦΑΓ βζλγπ ςζϟϝ ϝζϛϝ αεεζλζϟυ ϟμ ϟϝδ ΘΖΤ γμκαζλ με ν”««ΒΝ ςζϟϝ αλ ανναοδλϟ δξρζιζβοζρκ γζππμϐζαϟζμλ ϐμλπϟαλϟ Θγ με ”“ ± «͵ λΚ Ϟϝδ ΘΖΤ γμκαζλ ϐμλϟαζλπ ϟςμ βζλγζλϛ προεαϐδπ ϟϝαϟ αοδ γζεεδοδλϟζαιιυ ϟαοϛδϟδγ βυ σαοζμρπ ϟοαλπϐοζνϟζμλαι οδϛριαϟμου νομϟδζλπ Μλδ προεαϐδ με ΘΖΤ ϐαλ βζλγ ϟϝδ αϐϟζσαϟζμλ γμκαζλ με ϟϝδ κζτδγ ιζλδαϛδ ιδρθδκζα ΚΙΙΑΓ νομϟδζλ αλγ ϟϝδ ϜϞΙΣ» ϟοαλπαϐϟζσαϟμο Ϟατ ακμλϛ μϟϝδοπ Ϟϝδ μϟϝδο προεαϐδ με ΘΖΤ ϐαλ ϐμλϟαϐϟ ϟϝδ ϐδιιριαο ϟοαλπϐοζνϟζμλ εαϐϟμοπ ϐΚυβ μο ϐυϐιζϐ ΑΚΝ ϐΑΚΝ οδπνμλπδ διδκδλϟ βζλγζλϛ νομϟδζλ ΟΔΒ ϜΒΦΑΓ ςαπ γδϟδοκζλδγ ϟμ βζλγ ϟϝδ ΚΙΙΑΓβζλγζλϛ προεαϐδ με ΘΖΤ αλγ ϟμ ϐμκνδϟδ ςζϟϝ ΚΙΙΑΓ Ϟατ αλγ ν͵” εμο ΘΖΤ βζλγζλϛ ϜΒΦΑΓ ςαπ αγγζϟζμλαιιυ εμρλγ ϟμ πζϛλζεζϐαλϟιυ δλϝαλϐδ ϟϝδ βζλγζλϛ με ϟϝδ αϐϟζσαϟζμλ γμκαζλ με ϐΚυβ ϐΚυβΑΓ αλγ ΟΔΒ ϟμ ΘΖΤ ϜΒΦ ςαπ αιπμ πϝμςλ ϟμ ζλϝζβζϟ ϟοαλπϐοζνϟζμλαι αϐϟζσαϟζμλ κδγζαϟδγ βυ ΚΙΙΑΓ αλγ δλϝαλϐδ αϐϟζσαϟζμλ κδγζαϟδγ βυ ϐΚυβΑΓ Ϟϝδπδ οδπριϟπ ζλγζϐαϟδ ϟϝαϟ ϜΒΦ ζπ αβιδ ϟμ αιϟδο ϛδλδ δτνοδππζμλ βυ ϐμκνδϟζλϛ ςζϟϝ μλδ ϛομρν με ϟοαλπϐοζνϟζμλ εαϐϟμοπ εμο μϐϐρναλϐυ με ΘΖΤ ςϝζιδ δλϝαλϐζλϛ ϟϝδ βζλγζλϛ με μϟϝδο εαϐϟμοπ ϟμ α γζεεδοδλϟ προεαϐδ μλ ΘΖΤ
General note	Presented to the faculty of the Department of Interdisciplinary Biological Sciences.
General note	Advisor: Isabelle Lemasson.
General note	Title from PDF t.p. (viewed February 21, 2011).
Dissertation note	Ph.D. East Carolina University 2010.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

Availability

Library	Location	Call Number	Status	Item Actions
	Electronic Resources	Access Content Online	✔ Available

Molecular characterization of the activation domain of the HTLV-1 HBZ protein and its interaction with the KIX domain of the cellular transcriptional coactivators p300 and CBP / by Pamela Renee Cook.

Click here for more information about this title

Availability