| Contents |
The problem of genome instability. The multiplicity of mutations in human cancers / Ranga N. Venkatesan and Lawrence A. Loeb. Monitoring chromosome rearrangements / Michael R. Speicher -- DNA repair and mutagenesis. Nucleotide excision repair and its connection with cancer and ageing / Jaan-Olle Andressoo, Jan H.J. Hoeijmakers and Harm de Waard. DNA mismatch repair and colon cancer / Giancarlo Marra and Josef Jiricny. Base excision repair / Lisiane B. Meira, Nicholas E. Burgis and Leona D. Samson. Genomic instability in cancer development / Penny A. Jeggo. Translesion synthesis and error-prone polymerases / Catherine M. Green and Alan R. Lehmann -- Cell cycle progression and chromosome aberration. The INK4A/ARF network-cell cycle checkpoint or emergency brake? / Ana Gutierrez del Arroyo and Gordon Peters. DNA replication and genomic instability / Wenge Zhu, Tarek Abbas and Anindya Dutta. The dream of every chromosome: equal segregation for a healthy life of the host / Tomohiro Matsumoto and Mitsuhiro Yanagida. Telomere structural dynamics in genome integrity control and carcinogenesis / Roger A. Greenberg and K. Lenhard Rudolph. Gene amplification mechanisms / Michelle Debatisse and Bernard Malfoy. DNA methylation and cancer-associated genetic instability / Melanie Ehrlich. Deregulation of the centrosome cycle and the origin of chromosomal instability in cancer / Wilma L. Lingle, Kara Lukaswiewicz and Jeffrey L. Salisbury -- Genome integrity checkpoints. Mammalian DNA damage response pathway / Zhenkun Lou and Junjie Chen. ATM and cellular response to DNA damage / Martin F. Lavin ... [et al.] Mitotic checkpoint, aneuploidy and cancer / Tim J. Yen and Gary D. Kao. |
