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035 a| (Sirsi) o181588398;

035 a| (OCoLC)181588398;

049 a| EREE;

050 4 a| QP106.6b| .D38 2007;

100 1 a| Davanzo, Michael J.,e| author.?| UNAUTHORIZED;

245 14 a| The promotion of angiogenesis by a calcineurin regulated pathway /c| by Michael J. Davanzo.;

264 0 c| 2007.;

300 a| 40 leaves :b| illustrations ;c| 28 cm;

336 a| textb| txt2| rdacontent;

337 a| unmediatedb| n2| rdamedia;

338 a| volumeb| nc2| rdacarrier;

502 b| M.A.c| East Carolina Universityd| 2007;

500 a| Presented to the faculty of the Department of Exercise and Sport Science.;

500 a| Advisor: Timothy P. Gavin;

520 3 a| Skeletal muscle is heterogenic in nature such that one muscle contains several different muscle fiber types including I, IIA, and IIB fiber types. There are significant differences between muscle fiber types such that type I fibers demonstrate greater oxidative capacity and capillarization compared to type IIB fibers. Caleium, working through calcineurin (CaN), is a key determinant of muscle fiber type, such that over expression of CaN increases the number of oxidative muscle fibers (type I and IIA). We hypothesized that CaN also regulates skeletal muscle capillarization. At 10 weeks of age the plantaris muscle of wild-type (WT) (N=6) and CaN over expressing (MCK-CN) (N=5) mice was removed for the measurement skeletal muscle fiber type specific capillarization. The number of capillaries per fiber (C/Fi) was greater in type IIA fibers (WT: 1.30 ± 0.1 vs. MCK-CN: 1.70 ± 0.1) of MCK-CN compared to WT. There was no difference in either type I (WT: 1.72 ± 0.1 vs. MCK-CN: 1.87 ± 0.1) or type IIB fibers (WT: 1.84 ±0.1 vs. MCK-CN: 1.82 ±0.1). In conclusion, our data suggest that overexpression of CaN increases skeletal muscle capillarization of type IIA muscle fibers.;

504 a| Includes bibliographical references (leaves 33-40).;

650 0 a| Neovascularizationx| Regulation.=| ^A697772;

650 0 a| Phosphoprotein phosphatases.=| ^A689211;

650 0 a| Musclesx| Research.=| ^A1002;

650 0 a| Mice as laboratory animals.=| ^A848;

650 2 a| Phosphoprotein Phosphatases0| (DNLM)D010749=| ^A938972;

655 2 a| Academic Dissertation.0| (DNLM)D019478?| UNAUTHORIZED;

650 7 a| Mice as laboratory animals.2| fast0| (OCoLC)fst01019388;

650 7 a| Musclesx| Research.2| fast0| (OCoLC)fst01029981;

650 7 a| Neovascularizationx| Regulation.2| fast0| (OCoLC)fst01035917;

650 7 a| Phosphoprotein phosphatases.2| fast0| (OCoLC)fst01061427;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

700 1 a| Gavin, Timothy P.,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Exercise and Sport Science.?| UNAUTHORIZED;

856 41 z| Access via ScholarShipu| http://hdl.handle.net/10342/10353;

949 a| Click on web addressw| asish| joyner101;

949 a| Click on web addressw| asish| hsl111;

994 a| C0b| ERE;

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999 a| ASK AT SPECIAL COLLECTIONS DESKw| ASISc| 1i| MQ2268482l| JSCJTHDm| JOYNERr| Ys| Yt| JSCJTHDu| 11/20/2007x| ETDz| JSPECCOLLo| .STAFF. 0;

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The promotion of angiogenesis by a calcineurin regulated pathway / by Michael J. Davanzo.

Author/creator	Davanzo, Michael J. author.
Other author	Gavin, Timothy P., degree supervisor.
Other author	East Carolina University. Department of Exercise and Sport Science.
Format	Theses and dissertations
Production	2007.
Description	40 leaves : illustrations ; 28 cm
Supplemental Content	Access via ScholarShip
Subjects	Neovascularization--Regulation. Phosphoprotein phosphatases. Muscles--Research. Mice as laboratory animals. Phosphoprotein Phosphatases

Summary	Skeletal muscle is heterogenic in nature such that one muscle contains several different muscle fiber types including I, IIA, and IIB fiber types. There are significant differences between muscle fiber types such that type I fibers demonstrate greater oxidative capacity and capillarization compared to type IIB fibers. Caleium, working through calcineurin (CaN), is a key determinant of muscle fiber type, such that over expression of CaN increases the number of oxidative muscle fibers (type I and IIA). We hypothesized that CaN also regulates skeletal muscle capillarization. At 10 weeks of age the plantaris muscle of wild-type (WT) (N=6) and CaN over expressing (MCK-CN) (N=5) mice was removed for the measurement skeletal muscle fiber type specific capillarization. The number of capillaries per fiber (C/Fi) was greater in type IIA fibers (WT: 1.30 ± 0.1 vs. MCK-CN: 1.70 ± 0.1) of MCK-CN compared to WT. There was no difference in either type I (WT: 1.72 ± 0.1 vs. MCK-CN: 1.87 ± 0.1) or type IIB fibers (WT: 1.84 ±0.1 vs. MCK-CN: 1.82 ±0.1). In conclusion, our data suggest that overexpression of CaN increases skeletal muscle capillarization of type IIA muscle fibers.
General note	Presented to the faculty of the Department of Exercise and Sport Science.
General note	Advisor: Timothy P. Gavin
Dissertation note	M.A. East Carolina University 2007
Bibliography note	Includes bibliographical references (leaves 33-40).
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

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